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פרמקולוגיה 2

אנטי פיטרייתי

TermDefinition
amphotericin b .(Polyene) פוליאנים נקשר לארגוסטרול (סטרול בממברנה של פטריות) ויוצר חורים בממברנה → מוביל ליציאת יונים ולמוות תאי הפטריה .(Cryptococcus, Histoplasma, Aspergillus) זיהומים פטרייתיים סיסטמיים קשים משמש לעיתים עם פלוציטוזין לטיפול במנינגיטיס.
griseofulvin .(Antimitotic) אנטי-מיטוטי משבש את המיקרוטובולים בתא הפטרייה → מונע חלוקה תאית. טיפול בזיהומים עוריים של פטריות (Tinea – גזזת, פטרת ציפורניים).
fluconazloe .(Azoles) אזולים מעכב את האנזים 14α-Demethylase → מונע יצירת ארגוסטרול → פוגע בממברנה הפטרייתית. Cryptococcus – בשילוב עם Amphotericin B לטיפול במנינגיטיס. קנדידה (Candidiasis) – זיהומים אוראליים, וגינליים וסיסטמיים. Dermatophytes – פטריות עור.
Created by: Tzipora cantor
 

 



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