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biology lecture 12
regulating the cell cycle
| Question | Answer |
|---|---|
| when should a cell divide | during injury |
| where should a cell divide | in the tissue it came from |
| whcih type of cells should divide | only healthy cells should divide |
| how do receptors ensure proper cell division | they help with density dependent inhibition of growth |
| how do anchoring proteins ensure proper cell division | hold cells in place within their tissues and prevent cells from entering other tissues if they dislodge ( cell adhesion) |
| how do regulatory proteins ensure proper cell division | establish/run checkpoints |
| density dependent inhibition of growth | cells will only divide if space permits it |
| cell adhesion | cell is anchored to tissue, if anchoring is lost cell is told to commit apoptosis,killed, or fixed |
| G1 checkpoint | most important checkpoint, ensures that there is no dna damage |
| G2 checkpoint | has all DNA been properly replicated |
| M checkpoint | are all chromosomes properly aligned, are all kinetochores attached to spindle fibers |
| p53 protein | regulatory protein, runs checkpoints, tumor supressor, initiate DNA repair or apoptosis |
| what is cancer | unregulated cell growth due to changes in DNA which allows it to ignore regulatory mechanisms |
| cell senescence | once cells reach a certain point, they can no longer divide ( to prevent cells with accumulated damages) |
| 4 things that happen in a cancerous cell | . apoptosis signals are ignored .cell senescence is ignored (immortal) .checkpoints are ignored .increased sensitivity to growth signals |
| 4 causes of dna damage | .spontaneous ( erros in dna replication) .chemical ( asbestos, tobacco) .physical ( radiation) .infectious causes (bacteria, fungi, virus) |
| benign tumors | cells multiply in 1 place ( no metastisizing) dont harm host tissue ( dont even move to other areas of host tissue) usually 1st dna mutation |
| malignant tumors | metastasizing harm/invade host tissue angiogenesis ( may induce growth of BV to feed tumor) true cancer |