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MSK

MSK (Musculoskeletal)

GenericBrandPharmacologic CategoryCommon IndicationsKey Side EffectsUS Boxed WarningsOther Notes
tizanidine (PO) Zanaflex Alpha2 agonist Spasticity drowsiness, hypotension, dizziness, xerostomia, weakness
hydroxychloroquine (PO) Plaquenil Aminoquinolone RA, SLE, malaria retinal toxicity, rash, diarrhea use has been associated with cardiomyopathy, bone marrow suppression, and neuromuscular effects (i.e., myopathy, palsies, and progressive weakness)
colchicine (PO) Colcrys Antigout agent Gout diarrhea, nausea, vomiting, bone marrow suppression, myopathy (including rhabdomyolysis)
diclofenac (topical)* Voltaren Gel NSAID OA pruritus, rash
celecoxib (PO) Celebrex NSAID, COX-2 selective OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
diclofenac (PO) Voltaren NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
ibuprofen (PO)* Motrin, Advil NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
meloxicam (PO) Mobic NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
indomethacin (PO) Indocin NSAID OA, RA, acute pain, gout diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
naproxen (PO)* Naprosyn, Anaprox, Aleve NSAID OA, RA, acute pain, gout diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
ketorolac (PO, IV) Toradol NSAID Pain (indicated for short term use (≤ 5 days)) diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
cyclobenzaprine (PO) Flexeril, Amrix, Fexmid Skeletal muscle relaxant Muscle spasm drowsiness, dizziness, xerostomia, fatigue use may cause prolonged cardiac arrhythmias, and tachycardia; CI within 14 days of MAOI inhibitor therapy
methocarbamol (PO) Robaxin Skeletal muscle relaxant Muscle spasm drowsiness
baclofen (PO) --- Skeletal muscle relaxant Spasticity drowsiness
lidocaine (transdermal*, IV) Transdermal: Lidoderm, IV: Xylocaine Transdermal: topical analgesic IV: antiarrhythmic Transdermal: pain IV: ventricular arrhythmias Transdermal: dermatitis, erythema, urticaria, skin depigmentation, skin edema IV: bradycardia patch may remain in place for up to 12 hours in any 24-hour period, patch may be cut
allopurinol (PO) Zyloprim Xanthine oxidase Inhibitor Gout diarrhea, nausea, rash, leukopenia, thrombocytopenia rare association with severe (and potentially fatal) allopurinol hypersensitivity syndrome (risk highest in certain Asian populations)
succinylcholine (IV) Anectine Depolarizing neuromuscular blocking agent Neuromuscular blockade for intubation or procedures hyperkalemia, myalgia, malignant hyperthermia (rare) acute rhabdomyolysis and hyperkalemia leading to cardiac arrest and death in pediatric patients with undiagnosed skeletal muscle disease
etanercept (SQ) Enbrel Anti-tumor necrosis factor alpha inhibitor RA infection, injection site reaction, headache, nausea serious infections, malignancies such as lymphoma
adalimumab (SQ) Humira Anti-tumor necrosis factor alpha inhibitor RA, Crohn's Disease, Ulcerative Colitis infection, injection site reaction, headache, nausea serious infections, malignancies such as lymphoma
Created by: Jimmy57J
 

 



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