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Glycogen degradation

11/13/2024

QuestionAnswer
Glycogen is stored primarily in the liver and the muscle
Glycogen is phosphorylated
Phosphorylase cleaves glycogen to release glucose 1-phosphate
The phosphorylase catalyzes a phosphorolysis reaction which yields glucose 1-phosphate
phosphorolysis cleavage of a bond by the addition of orthophosphate
During phosphorolysis, you start with 4 glycogens and the phosphorylase cleaves 1 glycogen. How many are left connected? and how many are separated? 3 glycogen connected and 1 glucose separated
Phosphorolysis is very advantageous for breaking down glycogen
glycogen break down requires a debranching enzyme
A transferase moves a small oligosaccharide at branchpoint to nearby chain for a phosphorylase to cleave
8 phosphate groups make 8 molecules of glucose
the core initiates glycogen synthesis
debranching enzyme alpha-1,6-glucosidase
alpha-1,6-glucosidase then cleaves the a-1,6 bond at the branch point which releases a free glucose
the free glucose needs to be phosphorylated by hexokinase
cleaving the alpha 1,6 bond means to no longer have that branch
the free glucose gets phosphorylated by hexokinase to become glucose 6-phosphate
glycogen breakdown by a debranching enzyme is a hydrolysis reaction (alpha-1,6-Glucosidase plus H2O)
phosphoglucomutase converts G1P to glucose 6-phosphate
glucose 1,6 bisphosphate is the intermediate that works with phosphoglucomutase which performs conversion of G1P to G6P
Glucose 6-phosphate is phosphorylated at a serine residue
Phosphoglucomutase makes G6P in the muscles
Glucose 6-phosphatase makes free glucose in the liver
The liver can hydrolyze G6P to glucose
Free glucose is released from the liver into the blood for use by other tissues like brain and rbcs.
Glucose 6-phosphatase is absent in most other tissues
Glucose 6-phosphatase' fate is glycolytic pathways
Created by: user-1763258
 

 



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