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vectors of genes
Term | Definition |
---|---|
plasmid | any size gene and DNA, no cell specificity, no immune response trigger, doesn't insert itself into the middle of chromosome, less efficient at entering cells, needs a helper virus to replicate. |
liposome | genes of any size and DNA, no cell specificity, unlikely to trigger immune response, will not integrate into the host cells genome, less efficient |
herpes virus | carry a gene up to 20,000 bp and DNA, nervous system cells only, unlikely to trigger immune response but can cause one, will not integrate into the host cells genome, less efficient |
adeno-associated virus | carry a gene up to 5,000 bp and DNA, enter dividing and non dividing cells and variety of cell types, unlikely to trigger immune response, will integrate making effects long lasting, efficient at entering cells, helper virus to replicate |
adenovirus | carry a gene up to 7,500 bp and DNA, enter dividing and non dividing cells and variety of cell types, can cause an immune response, will not integrate so effects are temporary, efficient at entering cells |
retrovirus | carry a gene up to 8,000 bp and RNA, only effects dividing cells, can cause an immune response, will integrate making effects long lasting, only infects dividing cells, can cause cancer, not efficient at entering cells |
lentivirus | gene up to 8,500 bp & RNA, enter dividing and non dividing cells & variety of cell types, unlikely to cause immune response, will integrate making effects long lasting, efficient at entering cells so high levels of therapeutic protein production, cancer? |
Cas 9 | edits DNA in cells, potential to treat genetic disease, defeat viruses, produce better crops. binds to PAM sequence, unwinds DNA, bind guide RNA to complementary target DNA strand, |