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GI 2
GI 2 (Gastroenterology)
| Generic | Brand | Pharmacologic Category | Common Indications | Key Side Effects | US Boxed Warnings | Other Notes |
|---|---|---|---|---|---|---|
| famotidine (PO, IV) * | Pepcid, Zantac 360 | Histamine (H2) antagonist | GERD, erosive esophagitis, SUP | headache, constipation, diarrhea, mental status changes | ||
| dexlansoprazole (PO) | Dexilant | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia | increased risk of Clostridioides difficile infection | |
| esomeprazole (PO, IV) | Nexium | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia | increased risk of Clostridioides difficile infection | |
| lansoprazole (PO) | Prevacid | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia | increased risk of Clostridioides difficile infection | |
| omeprazole (PO) | Prilosec | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia | increased risk of Clostridioides difficile infection | |
| pantoprazole (PO, IV) | Protonix | Proton pump inhibitor (PPI) | GERD, PUD, erosive esophagitis, SUP | abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia | increased risk of Clostridioides difficile infection | |
| metoclopramide (PO, IV) | Reglan | Dopamine (D2) antagonist | Gastroparesis, GERD, nausea, vomiting | QTc prolongation, drowsiness, dystonia, akathisia, EPS, diarrhea | may cause tardive dyskinesia | |
| ondansetron (PO, IV) | Zofran | Selective serotonin (5-HT3) antagonist | Nausea, vomiting | QTc prolongation, headache, fatigue, constipation | ||
| promethazine (PO, IM, IV, PR) | Phenergan | Histamine (H1) blocker | Motion sickness, nausea, vomiting | QTc prolongation, drowsiness, dry mouth, blurred vision | potential for fatal respiratory depression in patients < 2 years old; injection can cause peripheral extravasation (preferred parenteral route is IM) | |
| meclizine (PO) | Bonine | Histamine (H1) blocker | Motion sickness, vertigo | drowsiness, dry mouth, blurred vision | ||
| diphenoxylate and atropine (PO) | Lomotil | Antidiarrheal | Diarrhea | nausea, confusion, drowsiness, dizziness, xerostomia, tachycardia, urinary retention | Do not use in diarrhea associated with enterotoxin-producing bacteria or in children <6 years of age | |
| sucralfate (PO) | Carafate | Gastrointestinal protectant | Duodenal ulcers | constipation, bezoar formation | take on an empty stomach; many drug interactions due to reducing absorption of other drugs |