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Endocrine 2
| Generic | Brand | Pharmacologic Category | Common Indication | Key Side Effects | Boxed Warnings | Other Notes |
|---|---|---|---|---|---|---|
| drospirenone and ethinyl estradiol (PO) | Yasmin, Yaz | Contraceptive | Contraception, acne | nausea, changes in flow, breast tenderness, thromboembolic disorders, headache | increased risk of cardiovascular events in women >35 who smoke | CI w/ hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease |
| levonorgestrel and ethinyl estradiol (PO) | Lutera, Levora, Seasonique | Contraceptive | Contraception, acne | nausea, changes in flow, breast tenderness, thromboembolic disorders, headache | increased risk of cardiovascular events in women >35 who smoke | CI w/ hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease |
| norethindrone and ethinyl estradiol (PO) | Junel, Loestrin, Microgestin | Contraceptive | Contraception, acne | nausea, changes in flow, breast tenderness, thromboembolic disorders, headache | increased risk of cardiovascular events in women >35 who smoke | CI w/ hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease |
| norethindrone, ethinyl estradiol, and ferrous fumarate (PO) | Lo Loestrin Fe, Microgestrin Fe | Contraceptive | Contraception, acne | nausea, changes in flow, breast tenderness, thromboembolic disorders, headache | increased risk of cardiovascular events in women >35 who smoke | CI w/ hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease |
| norgestimate and ethinyl estradiol (PO) | Tri-Sprintec, Sprintec | Contraceptive | Contraception, acne | nausea, changes in flow, breast tenderness, thromboembolic disorders, headache | increased risk of cardiovascular events in women >35 who smoke | CI w/ hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease |
| norgestrel and ethinyl estradiol (PO) | Crysell-28, Low-Orgestrel | Contraceptive | Contraception, acne | nausea, changes in flow, breast tenderness, thromboembolic disorders, headache | increased risk of cardiovascular events in women >35 who smoke | CI w/ hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease |
| estrogens, conjugated (equine) | Premarin | Estrogen derivative | Vasomotor symptoms and vaginal atrophy associated with menopause | irritation at site, abdominal pain, breast tenderness, thromboembolic disorders | increased risk of breast cancer, not for dementia prevention or cardio diseases; increased risk of endometrial cancer if not used with progestin | CI w/ hepatic dysfunction, thromboembolic disorders, breast cancer, cardiovascular disease, and estrogen-dependent tumor |
| estradiol (transdermal, PO) | Transdermal: Vivelle Dot PO: Estrace | Estrogen derivative | Vasomotor symptoms and vaginal atrophy associated with menopause | irritation at site, abdominal pain, breast tenderness, thromboembolic disorders | increased risk of breast cancer, not for dementia prevention or cardio diseases; increased risk of endometrial cancer if not used with progestin | CI w/ hepatic dysfunction, thromboembolic disorders, breast cancer, cardiovascular disease, and estrogen-dependent tumor |
| medroxyprogesterone (PO) | Provera | Progestin | Abnormal uterine bleeding, secondary amenorrhea | acne, abnormal bleeding, headache, amenorrhea | increased risk of breast cancer, not for dementia prevention or cardio diseases; | CI w/ hepatic dysfunction, thromboembolic disorders, breast cancer, cardio disease, and estrogen or progesterone-dependent tumors, undiagnosed abnormal genital bleeding, hepatic impairment |