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Endocrine 1
| Generic | Brand | Pharmacologic Category | Common Indication | Key Side Effects | Boxed Warnings | Other Notes |
|---|---|---|---|---|---|---|
| metformin (PO) | Glucophage, Glucophage XR | Biguanide | Type 2 DM, PCOS | N/V/D, B12 deficiency | lactic acidosis | CI w/ eGFR <30 |
| sitagliptin (PO) | Januvia, Zituvio | DPP-4 inhibitor | Type 2 DM | nasopharyngitis | --- | --- |
| empagliflozin (PO) | Jardiance | SGLT2 inhibitor | Type 2 DM, HF, CKD | UTI, genital mycotic infections | --- | --- |
| dapagliflozin (PO) | Farxiga | SGLT2 inhibitor | Type 2 DM, HF, CKD | UTI, genital mycotic infections | --- | --- |
| glimepiride (PO) | Amaryl | Sulfonylurea | Type 2 DM | hypoglycemia, weight gain | --- | --- |
| glipizide (PO) | Glucotrol, Glucotrol XL | Sulfonylurea | Type 2 DM | hypoglycemia, weight gain | --- | --- |
| pioglitazone (PO) | Actos | TZD | Type 2 DM | edema, weight gain, URTI | exacerbate CHF and CI in NYHA Class II and IV | --- |
| dulaglutide (SQ) | Trulicity | GLP-1r agonist | Type 2 DM | N/V/D, pancreatitis | risk of thyroid c-cell tumor | --- |
| liraglutide (SQ) | Victoza, Saxenda | GLP-1r agonist | Type 2 DM, chronic weight management | N/V/D, constipation, pancreatitis | risk of thyroid c-cell tumor; CI hx medullary thyroid cancer | --- |
| semaglutide (SQ) | Ozempic, Wegovy PO: Rybelsus | GLP-1r agonist | Type 2 DM, chronic weight management | N/V/D, constipation, pancreatitis | risk of thyroid c-cell tumor; CI hx medullary thyroid cancer | --- |
| tirzepatide (SQ) | Mounjaro, Zepbound | Dual GLP-1 and GIP agonist | Type 2 DM, chronic weight management | N/V/D, increased HR, pancreatitis | --- | --- |
| insulin glargine (SQ) | Lantus, Toujeo, Basaglar | long acting | Type 1 DM, Type 2 DM | hypoglycemia, weight gain | --- | --- |
| insulin NPH (SQ) | Humulin N, Novolin N | intermediate acting | Type 1 DM, Type 2 DM | hypoglycemia, weight gain | --- | --- |
| insulin aspart (SQ) | Novolog | rapid acting | Type 1 DM, Type 2 DM | hypoglycemia, weight gain | --- | --- |
| insulin lispro (SQ) | Humalog | rapid acting | Type 1 DM, Type 2 DM | hypoglycemia, weight gain | --- | --- |
| insulin regular (SQ,IV) | Humulin R, Novolin R | short acting | Type 1 DM, Type 2 DM, DKA | hypoglycemia, weight gain | --- | --- |