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PHO 3

GenericBrandPharmacologic CategoryCommon IndicationKey Side EffectsBoxed WarningsOther Notes
methotrexate (PO) Trexall Antimetabolite (folic acid antagonist) RA, Crohn's Disease, psoriasis, various hematologic and solid tumors stomatitis, N/V/D, thrombocytopenia, leukopenia, increased hepatic transaminases, pulmonary fibrosis serious toxic rxns; may cause fetal death or abnormalities; severe bone marrow suppression, anemia and toxicity w/ NSAIDS; cause hepatotoxicity, induce lung disease, pneumonitis taken w/ folic acid may reduce hematologic, GI, and hepatic side effects
cisplatin (IV, IT, IP) Kemoplat Antineoplastic agent, platinum-based compound Bladder, Ovarian, and Testicular cancer bone marrow suppression, N/V, nephro/neuro/oto-toxicity myelosuppresion, renal toxicity, neuropathy ---
doxorubicin (IV) Adriamycin Antineoplastic agent, anthracycline Adjuvant therapy for breast cancer cardiomyopathy, alopecia, N/V, bone marrow suppression secondary malignancies; extravasation can result in local tissue injury and necrosis may cause red discoloration of body fluids
pembrolizumab (IV) Keytruda Antineoplastic agent, monoclonal antibody Various cancers peripheral edema, pruritis, endocrine/metabolic abnormalities, N/V/D, constipation, hematuria, anemia, AST/ALT elevation, fatigue, MSK pain, increased SCr, dyspnea --- ---
anastrozole (PO) Arimedex Aromatase inhibitor Hormone receptor-positive breast cancer fatigue, rash, flushing, hot flashes, arthralgia, N/V, HTN, peripheral edema, osteoporosisfatigue, rash, flushing, hot flashes, arthralgia, N/V, HTN, peripheral edema, osteoporosis --- cardiovascular side effects, fetal toxicity
tamoxifen (PO) Soltamox Selective estrogen receptor modulator (SERM) Hormone receptor-positive breast cancer hot flashes, vaginal discharge, decreased bone density risk of uterine or endometrial cancer and thrombolytic events contraception use in premenopausal females (teratogenic); DNU w/ warfarin or hx DVT/PE
Created by: aarel01
 

 



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