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PHO 1
| Generic | Brand | Pharmacologic Category | Common Indication | Key Side Effects | Boxed Warnings | Other Notes |
|---|---|---|---|---|---|---|
| fentanyl (transdermal, IV) | Duragesic (transdermal), Sublimaze (IV) | Opioid analgesic | Pain | dizziness, drowsiness, itching, N/V, constipation, respiratory depression, pruritis | risk of addiction, abuse/misuse, neonatal induced w/drawl syndrome; w/benzos, alcohol (CNS depressants) lead to profound sedation, respiratory depression, and death | potential for med errors; 3A4 inhibs/inducers affect drug conc.; avoid heat exposure w/ patch |
| hydromorphone (PO, IV) | Dilaudid | Opioid analgesic | Pain | dizziness, drowsiness, itching, N/V, constipation, respiratory depression, pruritis | risk of addiction, abuse/misuse, neonatal induced w/drawl syndrome; w/benzos, alcohol (CNS depressants) lead to profound sedation, respiratory depression, and death | potential for med errors; use only in opioid-tolerant patients |
| morphine ER (PO) | MS Contin, Kadian | Opioid analgesic | Pain | dizziness, drowsiness, itching, N/V, constipation, respiratory depression, pruritis | risk of addiction, abuse/misuse, neonatal induced w/drawl syndrome; w/benzos, alcohol (CNS depressants) lead to profound sedation, respiratory depression, and death | coingestion w/ alcohol can result in fatal OD |
| morphine IR (PO, IV, IM, PR) | Duramorph, Infumorph (IV) | Opioid analgesic | Pain | dizziness, drowsiness, itching, N/V, constipation, respiratory depression, pruritis | risk of addiction, abuse/misuse, neonatal induced w/drawl syndrome; w/benzos, alcohol (CNS depressants) lead to profound sedation, respiratory depression, and death | --- |
| oxycodone (PO) | OxyContin, Roxicodone | Opioid analgesic | Pain | dizziness, drowsiness, itching, N/V, constipation, respiratory depression, pruritis | risk of addiction, abuse/misuse, neonatal induced w/drawl syndrome; w/benzos, alcohol (CNS depressants) lead to profound sedation, respiratory depression, and death | 3A4 inhibs/inducers affect drug conc. |
| methadone (PO, IV) | Dolophine | Opioid analgesic | Opioid use disorder, severe chronic pain | dizziness, drowsiness, N/V, constipation, respiratory depression, QTc prolongation | same as other opioids; QTc interval prolongation, serious arrhythmia (TdP) | --- |
| acetaminophen (PO, PR, IV) | Tylenol (PO, PR), Ofirmev (IV) | Analgesic (non-opioid), antipyretic | Pain, fever | N/V, increased hepatic transaminases | TDD should not exceed maximum daily limit; hepatotoxicity | --- |
| tramadol (PO) | Ultram, Ultram ER | Central analgesic; partial opioid agonist | Pain | dizziness, drowsiness, N/V, constipation, respiratory depression | serious or fatal respiratory depression | lowers seizure threshold |