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Neuro/Psych 3
| Generic | Brand | Pharmacologic Category | Common Indication | Key Side Effects | Boxed Warnings | Other Notes |
|---|---|---|---|---|---|---|
| lithium (PO) | Lithobid | Antimanic agent | Bipolar disorder | tremor, acne, hypothyroidism, weight gain, poly-uria/dipsia, GI upset | monitor levels promptly | narrow TI, monitoring recommended; avoid in pregnancy |
| sumatriptan (PO, intranasal, SQ) | Imitrex | Antimigraine | Migraine | fatigue, somnolence, dizziness, chest tightness, paresthesias | --- | CI in IHD, hx of stroke or TIA, PVD, and uncontrolled HTN |
| rizatriptan (PO) | Maxalt | Antimigraine | Migraine | fatigue, somnolence, dizziness, chest tightness, paresthesias | --- | CI in IHD, hx of stroke or TIA, PVD, and uncontrolled HTN |
| haloperidol (PO, IV, IM) | Haldol | 1st gen antipsychotic | Schizophrenia | sedation, EPS, parkinsonism, xerostomia, orthostatic hypotension, weight gain, QTc prolongation | increased risk of death in elderly w/ dementia-related psychosis | --- |
| clozapine (PO) | Clozaril | 2nd gen antipsychotic | Treatment-resistant schizophrenia | sedation, xerostomia, urinary retention, constipation, orthostatic hypotension, sialorrhea, hyperglycemia, weight gain | increased risk of death in elderly w/ dementia-related psychosis; severe neutropenia, orthostatic hypotension, bradycardia, syncope, seizures, fatal myocarditis and cardiomyopathy | risk of neutropenia requires monitoring of absolute neutrophil count (ANC) to receive Rx |
| aripiprazole (PO, IM) | Abilify, Aristada (IM) | 2nd gen antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | akathisia, restlessness, sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase risk of suicidal thoughts and behavior in younger populations; Increased risk of death in elderly w/ dementia-related psychosis | --- |
| quetiapine (PO) | Seroquel, Seroquel XR | 2nd gen antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase risk of suicidal thoughts and behavior in younger populations; Increased risk of death in elderly w/ dementia-related psychosis | --- |
| lurasidone (PO) | Latuda | 2nd gen antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase risk of suicidal thoughts and behavior in younger populations; Increased risk of death in elderly w/ dementia-related psychosis | CI w/ strong 3A4 inhibitors and inducers |
| olanzapine (PO) | Zyprexa | 2nd gen antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain | increased risk of death in elderly w/ dementia-related psychosis | --- |
| risperidone (PO, IM) | Risperdal (PO), Risperdal Consta (IM) | 2nd gen antipsychotic | Schizophrenia | sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain | increased risk of death in elderly w/ dementia-related psychosis | --- |