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Infectous d terms2
| Question | Answer |
|---|---|
| The presence of bacteria in the blood. | Bacteremia |
| An arthropod vector in which the disease-causing organism multiplies or develops within the arthropod prior to becoming infective for a susceptible individual. | Biological vector |
| A disease that may be transmitted either directly or indirectly between individuals by an infectious agent. | Communicable |
| The act of introducing pathogens (disease germs) or infectious material into or on an inanimate object. | Contamination |
| A disease that is continuously present in a given population/region but has low mortality. | Endemic The common cold would be an example of a disease that is continuously present in a population. |
| Organism disorder caused by an infectious agent already present in the body. | Endogenous infection |
| A thick-walled body produced by a bacterium to enable it to survive unfavorable environmental conditions and develop into new vegetative cells; characteristic of the genera Bacillus and Clostridium. | Endospore |
| A bacterial toxin confined within the body of a bacterium that is freed only when the bacterium cell producing it disintegrates/is broken down; found only in a gram-negative bacteria. | Endotoxin |
| An infectious disease or condition that is currently in higher than normal numbers in a given population. Appearance of an infectious disease or condition that attacks many people at the same time in the same geographical area. | Epidemic We commonly hear about flu (influenza) epidemics each year when cases spike to higher-than-normal numbers in a community. |
| Originating outside an organ or part; a form of infection caused by a pathogen or agent not normally present in the body. | Exogenous infection |
| A bacterial toxin produced by a microorganism within a living cell and excreted into its surrounding medium, generally protein in nature. | Exotoxin |
| One in which the organisms are originally confined to one area but enter the blood or lymph vessels and spread to other parts of the body. | Focal infection |
| Any inanimate object that harbors a disease agent and may serve to transmit it. | Fomite |
| An infection that involves the whole body | General infection ; also known as Systemic Infection. |
| A disease caused by microorganisms, especially those that release toxins or invade body tissues; the state or condition in which the body or a part of it is invaded by a pathogenic agent that, under favorable conditions, multiplies and produces injurious | Infection |
| An infection confined to one area of the body. | Local infection |
| A living organism capable of transmitting infections by carrying the disease agent on its external body parts or surfaces. | Mechanical vector |
| Infection caused by two or more organisms. | Mixed infection |
| The microbial population that lives with the host in a healthy condition; microorganisms that have become established in a given area; e.g. those organisms that have found a permanent home in some area of the human body. | Normal flora |
| An epidemic that has become very widespread or is worldwide. | Pandemic The COVID-19 virus quickly became a pandemic in 2020. |
| The state of producing or being able to produce pathological changes and disease; ability of a microorganism to cause disease. | Pathogenicity |
| An original infection from which a second infection originates. | Primary infection |
| Infection caused by a different organism than the one causing the primary infection; infection occurring in a host already suffering from an infection. | Secondary infection |
| Condition characterized by the presence of bacteria in the blood. condition characterized by the MULTIPLICATION of bacteria in the blood. | Septicemia |
| A disease which occurs occasionally in a random or isolated manner. | Sporadic Creutzfeldt-Jakob Disease (CJD) is a disease that, in the U.S., occurs at a rate of roughly 1 to 1.5 cases per 1 million population per year. |
| The presence of toxins in the blood. Blood distribution throughout the body of poisonous products of bacteria growing in a focal or local site, thus producing generalized symptoms. | Toxemia |
| A poisonous substance of plant, animal, bacterial, or fungal origin. | Toxin There are two general types of toxins that can make bacteria more virulent: 1. Exotoxin - 2. Endotoxin |
| An organism that, due to its own virulence, is able to produce disease. Real or genuine disease producing organism. | True pathogen |
| Relative power of an organism to produce disease. the degree to which they can cause disease); it is affected by many factors. | Virulence |
| Dilution or weakening of the virulence of a microorganism; reducing or abolishing pathogenicity. | Attenuation |
| A tissue reaction to irritation, infection, or injury marked by localized heat, swelling, redness, pain, and sometimes a loss of function. | Inflammation |
| body's overall defense against disease in general. | Resistance here are some people who seem to be sick all the time and others who rarely get sick. Those who are rarely sick have developed a high resistance to a broad category of diseases. |
| This is a specific defense of the body to protect against a specific disease. | Immunity For example, certain people are immune to poison ivy and can walk through it without developing any rash or other adverse reactions. |
| body's inability to ward off disease. | Susceptibility For example, AIDS patients are often susceptible to pneumonia (and a host of other diseases) because of their weakened immune system |
| Skin 2. Cilia and mucous membranes | A. Mechanical defenses |
| a. Inflammation is a tissue reaction to irritation, infection, or injury marked by these five cardinal signs: | b. Localized heat, swelling, redness, pain, loss of function |
| very few pathogens can survive higher body temperatures (102 - 104 degrees F.) | Fever |
| the engulfing and ingestion of bacteria or other material by cells known as phagocytes. | Phagocytosis |
| Physiological defenses | inflammation: 2. Fever - 3. Phagocytosis |
| enzyme secreted by the body that breaks down the cell wall of the invading pathogen. | Lysozyme |
| low pH destroys most pathogens that reach the stomach. | Gastric juice |
| interferes" with a virus' ability to replicate inside the body. | Interferon |
| C. Chemical defenses | Lysozyme b. Gastric juices 2. Interferon 3. Antibody |
| is a glycoprotein substance developed by the body in response to, and interacting with, an antigen | antibody ; also known as immunoglobulin. |
| is a foreign substance that stimulates the formation of antibodies that react specifically with it. | antigen |
| the ability to fight off disease having never been exposed to the antigen or antibody; you are usually born with this type of immunity. | Innate (Natural) immunity |
| you must either form the antibodies yourself or be given them from an artificial source (e.g. an injection.) | Acquired (Adaptive) immunity |
| the host receives the antigen or antibody from natural means. | Naturally-acquired immunity: the host receives the antigen or antibody from natural means. |
| having the disease and recovering from it. | Active Having chickenpox and recovering from it, which creates a natural immunity from there on, is the classic example of naturally-acquired active immunity. |
| placental transfer of antibodies and from colostrum (the first secretion from mammary glands after birth, rich in antibodies.) | Passive |
| the host receives the antigen or antibody by artificial means (in other words, from a needle injection.) | Artificially-acquired immunity |
| the antigen is transferred through a vaccine and triggers the body to create antibodies; this is a stronger artificial immunity that lasts much longer than the passive type | Active |
| Most vaccines utilize a microbe that has undergone the process of attenuation (dilution or weakening of the virulence of a microorganism; reducing or abolishing pathogenicity.) | attenuated microbe then stimulates the production of antibodies in the person who receives the vaccination. This is how the Hepatitis B vaccination works. |
| the antibody ITSELF is directly transferred to the sick person through a serum. Because the antibodies are introduced directly (i.e. the body did not create them), this is the weaker type of artificial immunity with a much shorter duration. | Passive |
| A vaccine creates immunity that is generally longer lasting than a serum. | t |
| a form of infection caused by a pathogen or agent not normally present in the body. | Exogenous infection |
| organism disorder caused by an infectious agent already present in the body. | Endogenous infection |
| The bacteria forms a spore when conditions become adverse. | Sporulating stage |
| The endospore germinates and begins growing as the normal bacteria. i.e. Germination | Vegetative stage |
| a. Anytime a person breathes in or out, microbes may move through the air into the airway. This is most common when a host is coughing, sneezing, etc. and air is passed out of the respiratory system. | 2. Droplet spray |
| As you can see, the droplets (less than five microns) do not travel far (usually less than 1m), so this type of transmission can only happen with direct person-to-person contact. | t |
| a. The transfer of a microbe from mother to infant in utero. | Congenital |
| over greater distances (i.e. not person-to-person) | Air This can be aerosolized particles from a person or it can be in the form of spores such as the Coccidioides immitis fungus that causes Coccidioidomycosis (also known as Valley Fever.) |
| some dirt contains microbes (usually in their sporulating form - e.g. C. perfringens) | Soil |
| a disease that can be transmitted from an animal to a person (e.g. rabies, Lyme disease) | Zoonosis |
| any agent that carries a disease from one host to another; may be animate (e.g. fly/mosquito) or inanimate (drinking cup or pencil). An inanimate vector is usually referred to as a fomite. | Vector |
| a. Biological vector transmission | *The microbe develops inside an insect which then bites a host (e.g. a mosquito bite) thereby infecting the (human) host. |
| b. Mechanical vector transmission | *An insect simply carries the microbe on the outside of its body; the microbe may or may not reproduce when transferred mechanically. |
| However, when our resistance (our overall ability to fight off disease) becomes compromised (e.g. not getting enough sleep, not drinking enough fluids), these can then cause problems. | normal flora |
| certain strains of Clostridia, Streptococcus, already inhabit our bodies. Our bodies normally keep these bacteria in check; however, if we become immuno-compromised, these bacteria already in our body can begin to multiply and cause disease. | Endogenous infection |
| would be stepping on a rusty nail and contracting the Clostridium tetani bacillus (via the wound), which causes the disease tetanus. C. tetani is a microbe not normally found in our bodies. | Exogenous infection |
| diseases do not spread from person-to-person (e.g. tetanus, which can only be contracted from a fomite such as a rusty nail.) | Non-communicable |
| coating that surrounds some bacterial cells; a loose gel-like structure that, in pathogenic bacteria, protect against phagocytosis microbe from antimicrobial agents; this is referring to phagocytes primary antimicrobial agent involved in phagocytosis | Capsule |
| Examples would be shaking hands (casual) or sexual intercourse (intimate.) | Physical contact |
| - person-to-person contact/transmission | . Direct transmission |
| generally involves a fomite or other inanimate object (e.g. food)water or other drinks | Indirect Transmission |
| microbes that are harmed by air and light/sunlight(i.e. not resistant to air and light) are transmitted by direct contact or biological vector transmission; in other words, they are transmitted in intimate ways that minimize their exposure to air or light | In a similar way, microbes that are transmitted by indirect contact or mechanical vector transmission are resistant to air and light |
| Portals of entry/exit | Skin B. Respiratory tract C. Digestive tract D. Genitourinary tract E. Placenta F. Vehicles of exit 1. Bodily fluids, secretions, and blood |
| You either form the antibodies yourself or be given them from an artificial source | Acquired (Adaptive) immunity |
| Placental transfer of antibodies and from colostrum | Naturally-acquired passive immunity |
| The ability to fight off disease having never been exposed to the antigen or antibody | Innate (Natural) immunity |
| Having the disease and recovering from it | Naturally-acquired active immunity |
| The antibody ITSELF is directly transferred to the sick person through a serum | Artificially-acquired passive immunity |
| The antigen is transferred through a vaccine and triggers the body to create antibodies | Artificially-acquired active immunity |
| Vaccines | Artificially-acquired ACTIVE immunity Relatively slow build up of antibodies Generally long-lasting Disease prevention |
| Serums | Artificially-acquired PASSIVE immunity Relatively quick build up of antibodies Generally short term Disease treatment |
| Damage human tissue | Enzymes |
| Causes blood to clot Found in connective tissue (e.g. skin) Helps bacteria penetrate into connective tissue and spread | Hyaluronidase |
| Digests fibrin threads in clotting blood | Fibrinolysin |
| Causes blood to clot | Coagulase |
| Helps bacteria colonize in skin/sebaceous glands (S. aureus) | Lipase |
| Humans infected with the disease Need for Universal Precautions | ALL HUMAN REMAINS ARE POTENTIALLY INFECTIOUS!!! |
| Microbes that are harbored in the environment will generally possess a spore which enables them to live outside of the host in adverse conditions. l | Water and soil |
| the first secretion from mammary glands after birth, rich in antibodies. | Colostrum |