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PEDIA

OSTEOSARCOMA Y SARCOMA DE EWING

QuestionAnswer
DEFINICIOON OSTEOSARCOMA Neoplasia maligna de alto grado PRIMARIA DE HUESO , caracterizada por FORMACION DE GHUESO INMADURO
Epidemiologia osteosarcoma Hombres jovenes 10 a25 anos, INCIIDENCIA 16 ANOS
Mutación mas frecuentemente encontrada en osteosarcoma P53
Causa mas frecuente de cáncer primaria de hueso OSTEOSARCOMA
Supervivencia de osteosarcoma a los 5 anos 60 a 80%
Predilección en que huesos OSTEOSARCOMA 1. Fémur distal 2. Humero proximal
IMAGEN DE SOL NACIENTE Destrucción de hueso medular que progresa a hueso cortical OSTEOSARFCOMA
CLINICA OSTEOSARCOMA 1. DOLOR , QUE NO CEDE AL TRATAMIENTO ANALGESICO/REPOSO /DURANTE LA NOCHE LLEGA A DESPERTAR AL PACIENTE. 2. Tumefacción 3. Metástasis a pulmón
DIAGNOSTICO DEFINITIVO OSTEOSARCOMA BIOPSIACIELO ABIERTO
Estudio inicial OSTEOSARCOMA RX PA Y LATERAL
Exámenes de laboratorio a solicitar como MARCADORES PRONOSTICOS en caso de osteosarcoma DHL FA
TRATAMIENTO OSTEOSARCOMA RESECCION QUIRURGICA
DEFINICION SARCOMA DE EWING Tumor indiferenciado de células pequeñas que proviene de la cresta neural afecta a ninos adolescentes y adultos
EPIDEMIOLOGIA SARCOMA DE EWING - 2do tumor óseo maligno mas frecuente - ESPECIAL INCIDENCIA ALOS 15 ANOS - Se asocia traslocación 11 y 22
SE PRESENTA COMO OSTEOLISIS Y REACCION PERIOSTICA CAPAS DE CEBOLLA EN RX SARCOMA DE EWING
QUE HUESO AFECTA PRINCIIPALMENTE EL SARCOMA DE EWING - Pelvis -Fémur DIAFISIS
CLINICA SARCOMA DE EWING DOLOR AUMENTA CON EL EJERCICIO TUMEFACCION MANIFESTACIONES SISTEMICAS :; fiebre, astenia, adinamia o perdida de peso
ESTUDIO INICIAL EWING RX AP Y LATERAL
DIAGNOSTICO DEFINITIVO SARCOMA DE EWING BIOPSIA + MOLECULAR POIR FISH O PCR
Marcadores pronósticos LABS DHL FA
TRATAMIENTO EWING Resección quirúrgica con márgenes amplios asociados a QUIMIOTERAPIA
SUPERVIVICENCIA SARCOMA DE EWING MALA 30% SIN METS MUERE 70% CON METS MUEREN
Created by: karmarodi
 

 



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