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HHIS

NERVOUS TISSUE and NERVOUS SYSTEM (PART 1)

QuestionAnswer
NERVOUS SYSTEM The MOST COMPLEX SYSTEM in the body
NERVOUS SYSTEM Formed by a network of many billion nerve cells (neurons), all assisted by many more supporting cells (glial cells)
NERVOUS SYSTEM The nervous tissue is distributed throughout the body as an integrated communications network
2 GENERAL DIVISIONS: Central Nervous System (CNS) Peripheral Nervous System (PNS)
Central Nervous System (CNS) Brain Spinal cord
Peripheral Nervous System (PNS) Cranial Nerves Spinal nerves Peripheral nerves Gangglia
DEVELOPMENT OF NERVE TISSUE The nervous system develops from the outermost of the 3 embryonic layer (ECTODERM), beginning in the 3rd week of development
DEVELOPMENT OF NERVE TISSUE (The process is termed as) NEUROLATION
SENSORY DIVISION SOMATIC VISCERAL
SOMATIC sensory input perceived consciously (eyes, ears, skins, muscular)
VISCERAL sensory input that are not perceived consciously (internal organs, cardiovascular structure)
MOTOR DIVISION (EFFERENT) A.SOMATIC: motor output controlled consciously or voluntarily (skeletal msucle effectors) B.AUTONOMIC: motor output not controlled consciously (heart or gland effectors
AUTONOMIC NERVOUS SYSTEM PARASYMPATHETIC DIVISION SYMPATHETIC DIVISION
PARASYMPATHETIC DIVISION Gangglia within or near the effector organs-an organ, such as muscle or gland, that responds to neural stimulation by producing a particularr response. Maintains normal body homeostasis
B.SYMPATHETIC DIVISION Gangglia close to the CNS Controls the body’s responses during emergencies and excitement.
NEURONS Also known as NERVE CELLS
NEURONS Structural and functional unit of the nervous system
NEURONS 3 MAIN PARTS: CELL BODY (SOMA OR PERIKARYON) DENDRITES AXON
CELL BODY (SOMA OR PERIKARYON) Contains the nucleus and most of the cell’s organs
CELL BODY (SOMA OR PERIKARYON) Serves as the synthetic or trophic (nutritive) center for the entire neuron
CELL BODY (SOMA OR PERIKARYON) Genetics center of a neuron
NUCLEUS spherical or oval, usually large, pale staining (purple), centrally located with a prominent nuclelous
CYTOPLASM ontains Niss’I granules (NissL substance, Nissl bodies, Chromatophilic substance)- basophilic granules due to the abundance of granular reticulum and ribosomes in the cytoplasm: main site of protein synthesis in the nueronal cytoplasm.
DENDRITES ETYMOLOGY “DENDRON” - Tree
DENDRITES Numerous elongated short processes extending from the perikaryon and specialized to receive stimuli from the environment, from the sensory epithelial cells or from other neurons at unique sites called synapses
DENDRITES Principal signal reception and processing sites on neurons
DENDRITES 200,000 axonal endings can make functional contact with the dendrites of a single large Purkinje cell of the cerebellum
DENDRITES Dendrites become much thinner as they branch
DENDRITES Nissl granules extend into the dendrites
AXON ETYMOLOGY “AXON” - Axis
AXON Single long process ending at synapses specialized to: generate and conduct nerve impulses to other cells
AXON Most neurons have only one axon, typically longer than its dendrites
AXON Axons may also receive information from other neurons
AXON Axons originate from a pyramid-shaped region of the perikaryon called: AXON HILLOCK
AXON PLASMA MEMBRANE OF AXON AXOLEMMA
AXON CONTENTS OF AN AXON AXOPLASM
STRUCTURAL CLASSES OF NEURONS PSEUDOUNIPOLAR BIPOLAR MULTIPOLAR ANAXONIC
PSEUDOUNIPOLAR Also known as UNIPOLAR NEURONS
PSEUDOUNIPOLAR Single process close to the perikaryon but divides into 2 branches, with the longer branch extending to a peripheral ending and the other toward the CNS
PSEUDOUNIPOLAR EXAMPLES Cerebrospinal ganglia
BIPOLAR Has 2 processes, consisting of a single dendrite and a single axon
BIPOLAR EXAMPLES Retina Olfactory epithelium Spiral/cochlea of the inner ear Vestibular ganglia of the inner ear
MULTIPOLAR More than 2 processes With one axon and two or more dendrites
MULTIPOLAR MOST COMMON
MULTIPOLAR EXAMPLES Motor neurons of CNS Peripheral autonomic ganglia
ANAXONIC  found only in certain CNS interneurons
ANAXONIC lack true axons , do not produce action potentials
ANAXONIC regulate local electrical changes of adjacent neurons.
TYPES OF NEURON ACCORDING TO FUNCTION SENSORY NEURONS MOTOR NEURONS INTER-NEURONS
SENSORY NEURONS Also known as AFFERENT NEURONS
SENSORY NEURONS Involved in: transmission of sensory stimuli from the environment or within the body
SENSORY NEURONS Transmits impulses to the CNS
MOTOR NEURONS Also known as EFFERENT NEURONS
MOTOR NEURONS Transmits impulses from: the CNS to the effector organs (skeletal muscle) or from other efferent neurons that ultimately supply the effectors (smooth muscles, cardiac muscles, and glands)
INTER-NEURONS Associated neurons that transmit impulses from one part of CNS to another
INTER-NEURONS Their processes do not leave the CNS
SYNAPSES Are sites where nerve impulses are transmitted from one neuron to another, or from neurons and other effector cells
SYNAPSES Its structure ensures that the transmission is unidirectional
SYNAPSES Synapses convert an electrical signal (nerve impulse) from the presynaptic cell into a chemical signal that affects the post-synaptic cell
SYNAPSES Most synapses act by: releasing neurotransmitters- which are usually small molecules bind specific receptor proteins to either open or close ion channels or initiate second messenger cascades
SYNAPSES Area of contact of one axon with the dendrites or perikaryon of another that possess polarity
PRE-SYNAPTIC AXON TERMINAL Also known TELEDENDRON MEMBRANE OR TERMINAL BOUTON
PRE-SYNAPTIC AXON TERMINAL Contains synaptic vesicles from which neurotransmitter is released by: EXOCYTOSIS
SYNAPTIC CLEFT Also known as: SYNAPTIC GAP
SYNAPTIC CLEFT 20-30 nm wide intercellular space that separates the pre-synaptic and post-synaptic membranes
POST-SYNAPTIC CELL MEMBRANE Contains receptors for the neurotransmitter, and ion channels or other mechanisms to initiate a new impulse
TYPES OF SYNAPSES 1.AXOSOMATIC SYNAPSE 2.AXODENDRITIC SYNAPSE 3.AXOAXONIC SYNAPSE: axons to axons
GLIAL/NEUROGLIAL CELLS Supporting cells of the CNS Support neuronal survival and activities
GLIAL/NEUROGLIAL CELLS They do not synapse with each other On H and E stain, only the nuclei are seen while the cytoplasm and processes of the neuroglia are not visible (HEMATOXYLIN AND EOSIN
NEUROGLIAL CELLS OF THE CNS ASTROCYTES OLIGODENDROCYTES MICROGLIAL CELLS EPENDYMAL CELLS
ASTROCYTES ETYMOLOGY “ASTRO”- Star “KYTOS”- Cells
ASTROCYTES Most important supporting cell if the CNS Most numerous glial cells of the brain
ASTROCYTES Nucleus is spherical, centrally located and pale staining Have large numbers of long radiating, branching processes
ASTROCYTES FUNCTIONS Help keep the blood brain barrier Regulates interstitial fluid composition
ASTROCYTES FUNCTIONS rovides structural support and organization to the CNS Assist with neuronal development Replicates to occupy spaces of ding neurons
ASTROCYTES TYPES FIBROUS ASTROCYTES PROTOPLASMIC ASTROCYTES
FIBROUS ASTROCYTES with long delicate processes; abundant in white matter
PROTOPLASMIC ASTROCYTES with many shorter processes; predominate in the gray matter
OLIGODENDROCYTES ETYMOLOGY “OLIGOS”- Small/Few “DENDRON”- Tree “KYTOS”- Cell
OLIGODENDROCYTES Extend many processes, each of which becomes sheet-like and wraps repeatedly around a portion of nearby CNS axon
OLIGODENDROCYTES Smaller and nucleus is round, small, and dense Precursor of the myelin sheaths which facilitates rapid transmission of nerve impulses
OLIGODENDROCYTES Processes are less numerous and shorter
OLIGODENDROCYTES Found in: both white and gray matter of the CNS
OLIGODENDROCYTES Most predominant glial cells in white matter
OLIGODENDROCYTES FUNCTIONS MYELINATES and insulates CNS axons Allows faster action potential propagation
MICROGLIAL CELLS Constitute the: major mechanism of immune defense in the CNS
MICROGLIAL CELLS Removes any microbial invaders and secretes a number of immunoregulatory cytokines
Created by: 1569455770155198
 

 



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