click below
click below
Normal Size Small Size show me how
HHIS
NERVOUS TISSUE and NERVOUS SYSTEM (PART 1)
| Question | Answer |
|---|---|
| NERVOUS SYSTEM | The MOST COMPLEX SYSTEM in the body |
| NERVOUS SYSTEM | Formed by a network of many billion nerve cells (neurons), all assisted by many more supporting cells (glial cells) |
| NERVOUS SYSTEM | The nervous tissue is distributed throughout the body as an integrated communications network |
| 2 GENERAL DIVISIONS: | Central Nervous System (CNS) Peripheral Nervous System (PNS) |
| Central Nervous System (CNS) | Brain Spinal cord |
| Peripheral Nervous System (PNS) | Cranial Nerves Spinal nerves Peripheral nerves Gangglia |
| DEVELOPMENT OF NERVE TISSUE | The nervous system develops from the outermost of the 3 embryonic layer (ECTODERM), beginning in the 3rd week of development |
| DEVELOPMENT OF NERVE TISSUE (The process is termed as) | NEUROLATION |
| SENSORY DIVISION | SOMATIC VISCERAL |
| SOMATIC | sensory input perceived consciously (eyes, ears, skins, muscular) |
| VISCERAL | sensory input that are not perceived consciously (internal organs, cardiovascular structure) |
| MOTOR DIVISION (EFFERENT) | A.SOMATIC: motor output controlled consciously or voluntarily (skeletal msucle effectors) B.AUTONOMIC: motor output not controlled consciously (heart or gland effectors |
| AUTONOMIC NERVOUS SYSTEM | PARASYMPATHETIC DIVISION SYMPATHETIC DIVISION |
| PARASYMPATHETIC DIVISION | Gangglia within or near the effector organs-an organ, such as muscle or gland, that responds to neural stimulation by producing a particularr response. Maintains normal body homeostasis |
| B.SYMPATHETIC DIVISION | Gangglia close to the CNS Controls the body’s responses during emergencies and excitement. |
| NEURONS Also known as | NERVE CELLS |
| NEURONS | Structural and functional unit of the nervous system |
| NEURONS 3 MAIN PARTS: | CELL BODY (SOMA OR PERIKARYON) DENDRITES AXON |
| CELL BODY (SOMA OR PERIKARYON) | Contains the nucleus and most of the cell’s organs |
| CELL BODY (SOMA OR PERIKARYON) | Serves as the synthetic or trophic (nutritive) center for the entire neuron |
| CELL BODY (SOMA OR PERIKARYON) | Genetics center of a neuron |
| NUCLEUS | spherical or oval, usually large, pale staining (purple), centrally located with a prominent nuclelous |
| CYTOPLASM | ontains Niss’I granules (NissL substance, Nissl bodies, Chromatophilic substance)- basophilic granules due to the abundance of granular reticulum and ribosomes in the cytoplasm: main site of protein synthesis in the nueronal cytoplasm. |
| DENDRITES ETYMOLOGY | “DENDRON” - Tree |
| DENDRITES | Numerous elongated short processes extending from the perikaryon and specialized to receive stimuli from the environment, from the sensory epithelial cells or from other neurons at unique sites called synapses |
| DENDRITES | Principal signal reception and processing sites on neurons |
| DENDRITES | 200,000 axonal endings can make functional contact with the dendrites of a single large Purkinje cell of the cerebellum |
| DENDRITES | Dendrites become much thinner as they branch |
| DENDRITES | Nissl granules extend into the dendrites |
| AXON ETYMOLOGY | “AXON” - Axis |
| AXON | Single long process ending at synapses specialized to: generate and conduct nerve impulses to other cells |
| AXON | Most neurons have only one axon, typically longer than its dendrites |
| AXON | Axons may also receive information from other neurons |
| AXON | Axons originate from a pyramid-shaped region of the perikaryon called: AXON HILLOCK |
| AXON PLASMA MEMBRANE OF AXON | AXOLEMMA |
| AXON CONTENTS OF AN AXON | AXOPLASM |
| STRUCTURAL CLASSES OF NEURONS | PSEUDOUNIPOLAR BIPOLAR MULTIPOLAR ANAXONIC |
| PSEUDOUNIPOLAR Also known as | UNIPOLAR NEURONS |
| PSEUDOUNIPOLAR | Single process close to the perikaryon but divides into 2 branches, with the longer branch extending to a peripheral ending and the other toward the CNS |
| PSEUDOUNIPOLAR EXAMPLES | Cerebrospinal ganglia |
| BIPOLAR | Has 2 processes, consisting of a single dendrite and a single axon |
| BIPOLAR EXAMPLES | Retina Olfactory epithelium Spiral/cochlea of the inner ear Vestibular ganglia of the inner ear |
| MULTIPOLAR | More than 2 processes With one axon and two or more dendrites |
| MULTIPOLAR | MOST COMMON |
| MULTIPOLAR EXAMPLES | Motor neurons of CNS Peripheral autonomic ganglia |
| ANAXONIC | found only in certain CNS interneurons |
| ANAXONIC | lack true axons , do not produce action potentials |
| ANAXONIC | regulate local electrical changes of adjacent neurons. |
| TYPES OF NEURON ACCORDING TO FUNCTION | SENSORY NEURONS MOTOR NEURONS INTER-NEURONS |
| SENSORY NEURONS Also known as | AFFERENT NEURONS |
| SENSORY NEURONS | Involved in: transmission of sensory stimuli from the environment or within the body |
| SENSORY NEURONS | Transmits impulses to the CNS |
| MOTOR NEURONS Also known as | EFFERENT NEURONS |
| MOTOR NEURONS | Transmits impulses from: the CNS to the effector organs (skeletal muscle) or from other efferent neurons that ultimately supply the effectors (smooth muscles, cardiac muscles, and glands) |
| INTER-NEURONS Associated neurons that | transmit impulses from one part of CNS to another |
| INTER-NEURONS | Their processes do not leave the CNS |
| SYNAPSES | Are sites where nerve impulses are transmitted from one neuron to another, or from neurons and other effector cells |
| SYNAPSES | Its structure ensures that the transmission is unidirectional |
| SYNAPSES | Synapses convert an electrical signal (nerve impulse) from the presynaptic cell into a chemical signal that affects the post-synaptic cell |
| SYNAPSES | Most synapses act by: releasing neurotransmitters- which are usually small molecules bind specific receptor proteins to either open or close ion channels or initiate second messenger cascades |
| SYNAPSES | Area of contact of one axon with the dendrites or perikaryon of another that possess polarity |
| PRE-SYNAPTIC AXON TERMINAL Also known | TELEDENDRON MEMBRANE OR TERMINAL BOUTON |
| PRE-SYNAPTIC AXON TERMINAL | Contains synaptic vesicles from which neurotransmitter is released by: EXOCYTOSIS |
| SYNAPTIC CLEFT Also known as: | SYNAPTIC GAP |
| SYNAPTIC CLEFT | 20-30 nm wide intercellular space that separates the pre-synaptic and post-synaptic membranes |
| POST-SYNAPTIC CELL MEMBRANE | Contains receptors for the neurotransmitter, and ion channels or other mechanisms to initiate a new impulse |
| TYPES OF SYNAPSES | 1.AXOSOMATIC SYNAPSE 2.AXODENDRITIC SYNAPSE 3.AXOAXONIC SYNAPSE: axons to axons |
| GLIAL/NEUROGLIAL CELLS | Supporting cells of the CNS Support neuronal survival and activities |
| GLIAL/NEUROGLIAL CELLS | They do not synapse with each other On H and E stain, only the nuclei are seen while the cytoplasm and processes of the neuroglia are not visible (HEMATOXYLIN AND EOSIN |
| NEUROGLIAL CELLS OF THE CNS | ASTROCYTES OLIGODENDROCYTES MICROGLIAL CELLS EPENDYMAL CELLS |
| ASTROCYTES ETYMOLOGY | “ASTRO”- Star “KYTOS”- Cells |
| ASTROCYTES | Most important supporting cell if the CNS Most numerous glial cells of the brain |
| ASTROCYTES | Nucleus is spherical, centrally located and pale staining Have large numbers of long radiating, branching processes |
| ASTROCYTES FUNCTIONS | Help keep the blood brain barrier Regulates interstitial fluid composition |
| ASTROCYTES FUNCTIONS | rovides structural support and organization to the CNS Assist with neuronal development Replicates to occupy spaces of ding neurons |
| ASTROCYTES TYPES | FIBROUS ASTROCYTES PROTOPLASMIC ASTROCYTES |
| FIBROUS ASTROCYTES | with long delicate processes; abundant in white matter |
| PROTOPLASMIC ASTROCYTES | with many shorter processes; predominate in the gray matter |
| OLIGODENDROCYTES ETYMOLOGY | “OLIGOS”- Small/Few “DENDRON”- Tree “KYTOS”- Cell |
| OLIGODENDROCYTES | Extend many processes, each of which becomes sheet-like and wraps repeatedly around a portion of nearby CNS axon |
| OLIGODENDROCYTES | Smaller and nucleus is round, small, and dense Precursor of the myelin sheaths which facilitates rapid transmission of nerve impulses |
| OLIGODENDROCYTES | Processes are less numerous and shorter |
| OLIGODENDROCYTES Found in: | both white and gray matter of the CNS |
| OLIGODENDROCYTES | Most predominant glial cells in white matter |
| OLIGODENDROCYTES FUNCTIONS | MYELINATES and insulates CNS axons Allows faster action potential propagation |
| MICROGLIAL CELLS | Constitute the: major mechanism of immune defense in the CNS |
| MICROGLIAL CELLS | Removes any microbial invaders and secretes a number of immunoregulatory cytokines |