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week 11
Pharmacology Week 11
| Question | Answer |
|---|---|
| Which description of clomiphene citrate’s mechanism of action is accurate? | Inhibits estrogen receptors in the hypothalamus and pituitary gland to secrete more FSH and LH to stimulate ovulation |
| Which statement about the pharmacokinetic parameters of testosterone is accurate? | Testosterone undergoes hepatic metabolism and beta-oxidation. |
| Which statements about the therapeutic use and pharmacodynamic parameters of clomiphene citrate are accurate? | - The drug’s elimination half-life is 5 to 7 days - Clomiphene citrate’s duration of action is 30 days. - The drug is indicated for use in women with persistent ovulatory dysfunction to stimulate ovulation. - When administered to women with polycystic |
| Which time frame represents the anticipated elimination half-life of most testosterone products? | 10 to 100 minutes |
| A nurse is caring for a patient who has been prescribed oral methyltestosterone therapy for infertility. This patient also takes warfarin and lisinopril. Which outcome and intervention are recommended to manage a potential drug interaction with methyltest | Methyltestosterone may increase the effects of warfarin; decrease the dosage of warfarin. |
| Which teaching points would a nurse share with a patient who has diabetes and is initiated on a gel formulation of testosterone? | - The drug can be transferred to others if is not completely dry. - The patient should not abruptly discontinue therapy with testosterone. - The patient should monitor his weight and report any weight gain of more than 5 lbs in a week. - The patient sh |
| A nurse is caring for a patient who has been prescribed clomiphene citrate for infertility. The patient also takes methyldopa for hypertension. Which outcome would a nurse anticipate may come from the drug interaction between methyldopa and clomiphene cit | - Impaired fertility due to an increase in prolactin |
| Which administration considerations would be given to a nurse who is caring for a patient initiated on clomiphene citrate? | - The dose may be taken with or without food. - The maximum number of sequential cycles of clomiphene citrate is three. - The initial dose of 50 mg once daily and may be increased by 50 mg/day for a second course if ovulation does not occur. - Ovulatio |
| Which patient parameters would a nurse inquire about when a patient returns to have his testosterone levels monitored? | - weight changes - mood alterations - blood glucose readings - blood pressure changes |
| Which indications can testosterone undecanoate be used to treat? | - hypogonadism - testicular failure for hormone replacement |
| Which statement accurately describes the pharmacokinetic parameters of clomiphene citrate? | The drug is readily absorbed following oral administration. |
| Which statements regarding the absorption of the various formulations of testosterone are accurate? | - Absorption is slow when the drug is given intramuscularly. - Oral absorption of testosterone may be reduced when taken with food. - Absorption is continuous over 24 hours when testosterone is administered with a patch. |
| Which molecules that serve as templates for protein production undergo enhanced synthesis by testosterone? | mRNA |
| Which medical conditions would the nurse ensure Mrs. Shell does not have as part of her pre-administration assessment? | - liver disease - abnormal uterine bleeding - uncontrolled thyroid/ adrenal dysfunction |
| Which teaching points will the nurse share with Mrs. Shell about clomiphene citrate therapy? | - Clomiphene citrate therapy may result in multiple births. -Significant fatigue may occur with clomiphene citrate therapy. -If pregnancy is suspected, a health care provider should be contacted. - The drug should be taken at the same time each day to |
| Which patients would a nurse determine cannot safely receive therapy with testosterone as part of fertility therapy? | - A 55-year-old with prostate cancer - A 48-year-old with a hematocrit of 56% |
| A nurse is caring for a patient who is receiving lamotrigine, an antiepileptic, and testosterone cypionate. Which drug interaction and suggested intervention would the nurse recommend to the health care provider? | Increased sex hormone-binding globulin, so an increase in testosterone therapy may be warranted |
| Match the site of application or route of administration to the testosterone product. 1. Methyltestosterone 2.Testoderm® 3. Testosterone solution 4. Fortesta® | 1. Shoulders 2. Gluteal muscle 3. Mouth (Orally) 4. Scrotal skin |
Created by:
Brandi Sizemore