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Human Phys ch. 19

QuestionAnswer
urine, the fluid waste produced by the kidneys, reflects the functioning of the body
ureter A smooth muscle tube connecting the bladder with the kidney
The bladder expands and fills with urine until, in a reflex called micturition or urination, the bladder contracts and expels urine through a single tube, the urethra
A cross section through a kidney shows that the interior is arranged in two layers: an outer cortex, and inner medulla.
The layers, cortex and medulla, are formed by the organized arrangement of microscopic tubules called Nephrons.
What is the functional unit of the kideny? The nephron
In the Renal portal system, blood flows from renal arteries into an afferent arteriole. From the afferent arteriole it goes into the first capillary bed, a ball-like network known as the glomerulus.
What are the three basic processes that occur in the nephron? Filtration, reabsorption, and excretion
Filtration the movement of fluid from blood into the lumen of the nephron. Filtration takes place only in the renal corpuscle, where the walls of glomcrular capillaries and Bowman’s capsule are modified to allow bulk flow of fluid
Filtrate Filtered fluid, once it passes into the lumen of the nephron, it becomes part of the body’s external environment,
anything that filters into the nephron is destined for Excretion, removal in the urine, unless it is reabsorbed in the body.
After filtrate leaves Bowman’s capsule, it is modified by reabsorption and secretion.
Reabsorption is the process of moving substances in the filtrate from the lumen of the tubule back into the blood flowing through peritubular capillaries.
Secretion selectively removes molecules from the blood and adds them to the filtrate in the tubule lumen.
The volume of fluid that filters into Bowman’s capsule per unit time is the glomerular filtration rate (GFR).
Average GFR is 125 mL/min, or 180 L/day
What are the four main functions of the Kidneys? Filtration, reabsorption, filtration, and excretion
What is the order in which filtrate travels through a nephron? Bowman's Capsule, Proximal tubule, Loop of Henle, Distal Tubule, Collecting duct
Anything that enters the nephron is destined for what? secretion
what is the filtrate that flows into the Bowman's capsule identical to? The plasma, and nearly isosmotic
What happens in the Bowman's Capsule? Filtration from the glomerulus into the nephron
What happens in the proximal tube? Isosmotic reabsorption of organic molecules, ions and water, as well as the secretion of xenobiotic materials and metabolites.
What is the primary function of the proximal tube? The isosmotic reabsorption of solutes and water
Of the different parts of the nephron, which is the primary site for the creation of dilute urine? The loop of henle
What is reabsorbed most in the loop of Henle? Solutes
The reabsorption of water and solutes from the tubule lumen to the extracellular fluid depends on active transport
Water leaves the tubule with solutes by osmosis
What is the primary driving force for most renal reabsorption? The reabsorption of Na+
What is the equation for the amount secreted? Amount filtered - amount reabsorbed + amount secreted
Reabsorption occurs when proximal tubule cells transport solutes out of the lumen, and water follows by osmosi
Sodium-linked secondary active transport in the nephron is responsible for the reabsorption of many substances, including glucose, amino acids, ions, and various organic metabolites
On the basolateral side of the cell, Na+ is pumped out by the Na+@K+@ATPase, while glucose diffuses out with the aid of a facilitated diffusion GLUT transporter.
The nitrogenous waste product urea has no active transporters in the proximal tubule but can move through the epithelial junctions by diffusion if there is a urea concentration gradient.
When Na+ and other solutes are reabsorbed from the proximal tubule, the transfer of osmotically active particles makes the extracellular fluid more concentrated than the filtrate remaining in the lumen
In response to the osmotic gradient, water moves by osmosis across the epithelium. Up to this point, no urea molecules have moved out of the lumen because there has been no urea concentration gradient.
When water is reabsorbed, the concentration of urea in the lumen increases—the same amount of urea is contained in a smaller volume. Once a concentration gradient for urea exists, urea moves out of the lumen.
Saturation refers to the maximum rate of transport that occurs when all available carriers are occupied by (are saturated with) substrate
At substrate concentrations below the saturation point, transport rate is directly related to substrate concentration
At substrate concentrations equal to or above the saturation point, transport occurs at a maximum rate. The transport rate at saturation is the transport maximum
In diabetus Militus, glucose is filtered faster than the carriers can reabsorb it. The carriers become saturated and are unable to reabsorb all the glucose that flows through the tubule. As a result, some glucose escapes reabsorption and is excreted in the urine.
What is the formula for glucose excreted? Glucose excreted = glucose filtered - glucose reabsorbed
Under normal conditions, all filtered glucose is reabsorbed. In other words, filtration is equal to reabsorption.
Created by: jacquixg
 

 



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