click below
click below
Normal Size Small Size show me how
Electrolytes10/09
Question | Answer |
---|---|
Subject to circadian rhythms | Phosphate |
No tourniquet or hand exercise used | Lactate |
Put specimen on ice | Lactate |
Indicator of severe O2 deprivation | Lactate |
Two Types of this: Hypoxic conditions,(shock, MI, pulmonary edema) and Metabolic origins (Diabetes mellitus, infection, leukemia, liver or renal disease) | Lactic Acidosis |
DNA and RNA makeup | Phosphate |
Is a component of most enzymes | Phosphate |
Comes from diet, released from cells into blood, and lost from bone | Phosphate |
Is regulated through renal excretion and reabsorption | Phosphate |
Affected by PTH, Vitamin D, and Growth Hormone | Phosphate |
Colorometric Analysis using Ammonium Phosphomolybdate Complex or Molybdenum Blue | Phosphate |
Major intracellular anion in hydroxyapatite crystals | Phosphate |
Major extracellular cation that determines the solubility of plasma | Sodium |
Uses the ATPase pump | Sodium and Potassium |
Concentration is regulated by water intake, excretion, and blood volume | Sodium |
Hyponatremia is defined as | less than 135 mmol/L |
Hyponatremia is caused by | Sodium loss, Decreased aldosterone, Decreased Potassium, inc water retention, water imbalance |
Hypernatremia is caused by | Water loss, diabetes insipidus, ADH secretion impaired, too much aldosterone,renal tubular disorder |
ISE is most used, but there is buildup of protein on electrode membranes | Sodium |
Major component of buffering system in the blood | bicarbonate |
Chloride Shift exchanges: | Bicarbonate with Chloride |
How much bicarbonate is reabsorbed kidneys? | 85% |
By what form is Bicarbonate absorbed in tubules and into extracellular fluid? | CO2 |
Response to alkadosis | Kidneys excrete bicarbonate in urine and retain Na+ |
Response to acidosis | Kidneys excrete H+ in the urine and totally reabsorb HCO3 |
Response to metabolic acidosis | Hyperventilation |
Response to metabolic alkalosis | Hypoventilation |
PCO2 electrode measures | Total CO2 |
Enzymatic reaction for HCO3 | Phosphenolpyruvate Carboxylase and Malate Dehydrogenase, measure NADH |
Sample MUST STAY CAPPED until analysis | Bicarbonate |
Major extracellular Anion | Chloride |
Functions are: Maintains osmotic pressure, proper body hydration, ionic neutrality, and blood volume | Chloride |
Regulated by Diet and Absorption in GI tract, Passive absorption in proximal tubules, Electrical Neutrality | Chloride |
State of excessive loss of bicarbonate ions, and is accompanied by hypernatremnia: | Hyperchloremia |
Sweat determines presence of Cystic Fibrosis | Chloride |
Amperometric-Coulometric titration | Ag+ binds to Cl- for qunatification |
Colormetric anaylsis for Chloride | displacement of thiocyanate from mercuric thiocyanate, and reaction with ferric ion to form color |
ISE is most used | Chloride |
Major intracellular cation | Potassium |
Concentration within cell is 20X concentration outside of cell | Potassium |
Functions are neromuscular excitability, contractions of the heart, intracellular fluid volume, and hydrogen ion concentration | Potassium |
Aldosterone regulates the secretion of this in exchange for Na+ into the urine in distal tubule and collecting duct | Potassium |
Distal nephron is the principle determinant of urinary excretion | Potassium |
Concentration is regulated by ATPase pump | Potassium and Sodium |
Catecholamines and insulin does what to ATPase pump? | Increases activity to promote cellular entry of K+ |
Propanol (beta blocker) does what to ATPase pump? | Impairs cellular entry of K+ |
Causes release of H+ and intake of Na+ and K+ | Alkalemia |
Hypoxia, overdose of digoxin, or hypomagnesemia does what to ATPase pump? | Inhibition of pump |
Hypokalemia is defined as: | less than 3mmol/L |
ISE uses valinomycin membrane | Potassium |
Hemolysis should most definitely be avoided! | Potassium!, as well as Magnesium |
Decreased renal excretion, Cellular Shifts, acidosis, leukemia, exercise causes too much of what? | Potassium |
This is Essential for life functions | Magnesium |
Essential cofactor for more than 300 enzymes | Magnesium |
Involved in DNA transcription, Oxidative Phosphorylation, and Transmembrane transport | Magnesium |
55-60% in free form, 25-30% bound to albumin, and 15% complexed to anions | Magnesium |
50% found in bone, 35-45% intracellular, and 1-2% extracellular | Magnesium |
Fourth most abundant Cation and Second most abundant Intracellular Ion | Magnesium |
Renal Threshold for Magnesium is | 0.60-0.85 mmol/L |
Regulation is controlled by Kidney and Parathyroid Hormone (PTH) | Magnesium |
Increased antacids, acute or chronic renal failure, bone carcinoma or dehydration causes: | Hypermagnesemia |
Colorometric methods include Calamagite, Formazen dye, Methythymol blue | Magnesium |
Urine must be acidified first | magnesium |
A divalent Cation; average human body contains 1 KG | Calcium |
40-45% bound to proteins, 10% complexed to anions; 45-50% free | Calcium |
Calcium is controlled by these 3 hormones | PTH, Vitamin D, Calcitonin |
In bone, causes activation of osteoclasts to break down; in kidneys, causes increased Calcium absorption in tubules, and causes renal stimulation of Vitamin D | PTH |
Works with PTH to increase Calcium absorption in intestine, and stimulates bone reabsorption | Vitamin D |
Secreted when there are high levels of Calcium to inhibit the action of both PTH and Vit.D | Calcitonin from the thyroid gland |
This condition results from Primary hypoparathyroidism, hypomagnesemia, and hypermagnesemia, Acute Pancreatitis, Hypoalbuiminemia, and Vitamin D deficiencies | Hypocalcemia |
This condition results from hyperparathyroidism, malignancies, endocrine disorder, prolonged immobilzation, Vit. D Toxicity | Hypercalcemia |
Cannot use Lithium Heparin tube because it will bind to this | Calcium |
Functions are neuromuscular transmission (CNS), cardiac function and cofactor in blood coagulation | Calcium |
Analysis uses lactate oxidase and Hydrogen Peroxide | Lactate |