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Initiation stage period
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Bud Stage period
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Initiation stage period 6-7th week
Bud Stage period 8th wk
Cap Stage period 9-10th wk
Bell Stage period 11-12th wk
Apposition Stage period Varies per tooth
Maturation Stage period Varies per tooth
Initiation description Ectoderm lining of stomodeum gives rise to oral epithelium and then to dental lamina, adjacent to deeper ectomesenchyme, which is influenced by the neural crest cells. Both tissues are separated by a basement membrane
Bud stage description Growth of dental lamina into bud that penetrates growing ectomesenchyme
Cap stage description Enamel organ forms into cap, surrounding mass of dental papilla from the ectomesenchyme and surrounded by mass of dental sac also from the ectomesenchyme. Formation of the tooth germ
Bell stage description Differentiation of enamel organ into bell with four cell types and dental papilla into two cell types
Apposition stage description Dental tissues secreted as matrix in successive layers
Maturation stage description Dental tissues fully mineralize to their mature levels
Enamel embryological background Enamel organ
Enamel tissue type Epithelial
Formative cells of enamel Ameloblasts
Incremental lines of enamel lines of Retzius
Mature cells of enamel None-lost with eruption
Resorptive cells of enamel odontoclasts
Inorganic mineral levels-enamel 96%
Organic/water levels-enamel 1% organic and 3% water
Tissue formation after eruption-enamel None
Enamel vascularity None
Enamel innervation None
Dentin embryological background Dental papilla
Tissue type for dentin Connective tissue
formative cells of dentin Odontoblasts
Incremental lines of dentin Imbrication lines of von Ebner
Mature cells of dentin Only dentinal tubules with processes
Resorptive cells of dentin Odontoclasts
Inorganic mineral levels of dentin 70%
Organic/water levels-dentin 20% organic 10% water
Dentin tissue formation after eruption ? Possible
Vascularity of dentin? none
Innervation of dentin? Present
Cementum embryological background Dental papilla
Cementum tissue type Connective tissue
Cementum formative cells Cementoblasts
Cementum incremental lines Arrest and reversal lines
Cementum mature cells Cementocytes
Resorptive cells of cementum odontoclasts
Cementum inorganic levels 65%
Cementum organic/water levels 23% organic 12% water
Cementum tissue formation after eruption? possible
Vascularity of cementum? none
Cementum innervation? None
Alveolar bone embryological background Mesoderm
Alveolar bone tissue type Connective tissue
Alveolar bone formative cells osteoblasts
Alveolar bone incremental lines Arrest and reversal
Alveolar bone mature cells Osteocytes
Alveolar bone resorptive cells Osteoclasts
Alveolar bone inorganic levels 60%
Alveolar bone organic and water levels 25% organic 15% water
Alveolar bone tissue formation after eruption? possible
Vascularity of alveolar bone? present
Innervention of alveolar bone? present
Influence ectodermal tissues in order for initiation of odontogenesis Mesenchymal tissues
Tissue lining stomodeum Ectoderm
Outer portion of ectoderm gives rise to Oral epithelium
Acellular structure separates oral epithelium and ectomesenchyme in stomodeum Basement membrane
spithelium grows deeper into the ectomesenchyme and induced to produce this layer during 7th wk Dental lamina
Dental lamina begins initially to form in the midline for both arches and progresses posteriorly
This stage is named for an extensive proliferation/growth of dental lamina into buds penetrating into the ectomesenchyme Bud Stage
At the end of proliferation process involving dental lamina both future maxillary arch and mandibular arch will each have 10 buds
In the bud stage the basement membrane is between the bed and growing ectomesenchyme
In bud stage each bud from dental lamina with surrounding ectomesenchyme develop into a tooth germ
all teeth and associated tieeues develop from ectoderm and mesenchymal tissue
ectoderm and mesenchymal tissue ectomesenchyme
development of all teeth and associated tissue is influenced by neural crest cells
Only this process of the ectoderm and mesenchymal tissues occurs in the bell stage Proliferation
In areas where teeth will not be forming dental lamina only remains thickened
non-tooth-producing portion of the dental lamina disintegrates as the developing oral mucosa comes to line the oral cavity
3 components of tooth germ Enamel organ, Dental papilla, Dental sac
Enamel Organ Produces enamel
Physiological process (5 stages of growth) Induction, Proliferation, Differentiation, Morphogenesis, Maturation
Induction Stage - Interaction between embryolocical tissues
Proliferation Stage - Controlled cellular growth
Differentiation Stage - Change in embryonic cells, Specialized cells do different jobs
Morphogenesis Stage - Process of development of specific tissue morphology
Maturation Stage - Hard dental tissues are fully calcified, Fully developed
Stages of Odontogenesis - Initation Stage, Bud Stage, Cap Stage, Bell Stage, Apposition
Dental Lamina Produces forms what? - Midline if each arch and progresses posteriorly
Initiation stage of Odontogenesis produces which layer? Dental Lamina
The physiological process of proliferation occurs in which stage? Bud Stage
During the Bud Stage - Growth of dental lamina into buds or oval masses occurs
Penetration of the growing ectomesenchyme is by the Buds
Future arches have how many buds each? 10 buds per arch
Each tooth bud from dental lamina will develop into what? - A tooth germ and its associated supporting tissues:o Enamel organ, Dental papilla, Dental sac
Which stage occurs between the 9th and 10th week of prenatal development? Cap Stage
What physiological processes are the cap stage derived from? - Proliferation, differentiation, morphogenesis
Which physiological process is the predominant process in the cap stage? morphogenesis
What occurs during the cap stage? - Unequal growth in different parts of the tooth bud
In the cap stage - Formation of cap shape attached to dental lamina
The Bud is an actual cell tooth germ in this stage Cap stage
The depression in the deepest part of the tooth bud forms what and in what stage? - The enamel organ in the cap stage
Within the concavity of the cap of enamel organ, the inner mass of ectomesenchyme is called? - Dental Papilla (Cap stage)
The basement membrane between the enamel organ and dental papilla is the future site of? DEJ
Remaining ectomesenchyme on the outside of the enamel organ condenses into? Dental Sac
At the end of the cap stage, the enamel organ, dental papilla, and dental sac are referred to as? Tooth Germ
Initiation for permanent anterior teeth is at which week? the 10th week in the cap stage
Successional dental lamina will forms what? - succedaneous teeth (permanents)
Primary dental lamina develops an extension off of each tooth bud on the lingual side is called? - Successional dental lamina
Which teeth develop from posterior extensions of dental lamina distal to the primary 2nd molar’s dental lamina? - Permanent molars (non succedaneous)
Tooth germ forms during which stage? - Cap stage
The rest of the cells not in the dental concavity are in? - The dental sac
Which stage occurs between the 11th and 12th week of prenatal development? - The bell stage
The physiological processes that occur in the Bell stage are? - proliferation, differentiation, and morphogenesis
The predominant physiological process that occurs in the Bell stage is? - Differentiation
During the Bell stage - The cap shape of enamel organ assumes a bell shape
What are the different types of cells found in the enamel organ? - Outer enamel epithelium(OEE), Inner enamel epithelium(IEE), Stellate reticulum, Stratum intermedium
Small cuboidal cells, one cell layer thick that outline the shape of the enamel organ - Outer enamel epithelium (OEE)
Innermost tall columnar cells on the concave side, one cell layer thick - Inner enamel epithelium (IEE)
IEE cells differentiate into - Ameloblasts
Outer star-shaped cells, many layers thick that fill and form a network in the enamel organ - Stellate reticulum
Stellate reticulum cells are responsible for - production of enamel matrix; protection for IEE and nourishment of stratum intermedium
Stellate reticulum are located inbetween which two cells - OEE and IEE
Inner compressed layer of flat to cuboidal cells - Stratum intermedium
Stratum intermedium is the layer between which two cells? - Stellate reticulum and IEE
The job of the stratum intermedium is to? - Produce enamel matrix
Stratum intermedium provide nourishment for? - IEE and ameloblasts
The two types of tissues/layers in the Dental papilla are? - Outer cells and Central cells
Outer cells are peripheral cells that differentiate into? - odontoblasts (form dentin)
Central cells are inner cells that differentiate into? - Pulp tissue
Final stage of odontogenesis - Apposition stage
During the apposition stage what occurs? - Enamel, dentin, and cementum are secreted in matrix and then into layers
Maturation is reached when? - dental tissues become fully mineralized
In the apposition stage what is necessary for production of enamel, dentin, and cementum? - Interactions between enamel organ, dental papilla and dental sac
This cell elongates as it differentiates into premeloblasts - IEE cells
These cells induce outer cells of dental papilla to differentiate into odontoblasts - Preameloblasts
These cells begin dentinogenesis or predentin - Odontoblasts
Dentinogenesis is - The apposition of dentin matrix
Odontoblasts start the matrix activity before - enamel matrix production begins
This is found between preameloblasts and odontoblasts and disinegrates - Basement membrane
During the apposition stage this cell is in contact with newly formed predentin - Odontoblasts
What causes preameloblasts to differentiate into ameloblasts - Odontoblasts being in contact with predentin
Amelogenesis is - The apposition of enamel matrix
Disintegration of the basement membrane forms what? - The DEJ
Disintegration of the basement membrane cases what? - Preameloblasts to differentiate into ameloblasts
This takes place after the crown is completely shaped and the tooth is starting to erupt into the oral cavity? - Root development
The OEE and the IEE combine together at the most cervical portion of enamel organ is called? - Cervical loop
The cervical loop is responsible for? - root development
Cervical loop grows deeper into the enamel sac, elongates, and moves away from the crown area and encloses more of the dental papilla tissue to form - Herwig’s epithelial root shealth(HERS)
The function of HERS is - to shape the roots and induce dentin formation in root area
HERS is located between - dental papilla and dental sac
IEE of HERS differentiate and become - odontoblasts
Odontoblasts from the IEE of HERS form what? - Root dentin
Odontoblastic differentiation occurs due to a - Lack of stellate reticulum and stratum intermedium layers
What occurs when root dentin is completed? - Basement membrane of HERS disintegrates
After the disintegration of HERS its cells may become what? - epithelial rests of Malassez
Rests of Malassez is a group of cells located in? - mature periodontal ligament
Rests of Malassez cells may cause problems by becoming what? - cystic
Cap Stage of Odontogenesis - Tooth bud of dental lamina grows into cap shape
Bell Stage of Odontogenesis - Differentiation occurs and enamel organ assumes bell shape
Apposition Stage of Odontogenesis - Layered formation of hard tissue
Created by: oceanrescue6
 

 



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