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blood bank review

QuestionAnswer
if results of quality control testing of reagents re not as expected what i the first corrective course of action step rerun the test
quality control is the the same as quality assurance false
quality control is the process that validates final results and quantifies variation true
what might lead to unacceptable quality control results 1. a technician who has not worked in the area for several months 2. a deteriorated anti-A reagent 3. an uncalibrated serofuge
what are the three building blocks of an effective quality management program 1. quality control 2. quality assurance 3. quality systems
what are the responsibilities of the quality assurance department of blood bank 1. perform internal audits 2. review dastard operating procedures 3. review and approving training program
define quality assurance a set of panned actions to provide confidence that systems and elements that influence the quality of the product or service are working as expect individually and collectively
why is quality control important in blood banking 1. helps report accurate test results 2. helps release blood produces 3. reproduce test results uniformly between fellow technicians
what is the purpose of current good manufacturing practices to mandate and control quality assurance in the blood bank
name a few essentials that are apart of the quality system for donor centers and transfusion services 1. organization 2. documents and records 3. process improvement
A physician complains saying she has not got a tst report from blood bank what do you do prepare a copy of the report for he physician
AA BB American association blood bank
JCAHO joint commission assessment healthcare
CAP college american pathologist
FDA food and drug administration
explain how quality control helps with reagents 1.lots of antigens and reagent blood cells must be tested to show the reagent functions 2. on day and prior to use reagent and blood cells must be shown to react and less common used cells must have controls ran pos/neg 3. no visible contamination
name some of the ten quality system essential for donor centers and transfusion centers 1. purchasing 2. internal and external checks 3. equipment 4. organization
who discovered the ABO blood groups Karl Landsteiner
complement is a group of plasma proteins in fresh serum, which is necessary for hemolysis to occur
where are antigens located on the RBCs of patients and donors
where are naturally occurring and immune RBC antibodies found in the plasma and serum of patients
what is the study of the science of blood group antigens and antibodies called immunohematology
the antibody that is formed in the greatest amount in the serum during a PRIMARY immune response is IgM
name the five major classifications of immunoglobulins IgG, IgM, IgE, IgD, and IgA
what antibody is produced in greater amounts in a SECONDARY immune response IgG
antibodies are formed by what B lymphocytes
B lymphocytes provide us with what type of immune response humoral
T lymphocytes provide us with what type of immune response cell-mediated
name two characteristics of a PRIMARY immune response long lag phase and production of IgM antibodies first
name two characteristics of a SECONDARY immune response short lag phase and production of IgG antibodies first
what is the primary way to observe antigen antibody reactions agglutination
what does AHG Anti-human globulin
another name for immunoglbulin antibody
IgM reacts an what temperature 24C
IgG reacts an what temperature 37C
antigen antibody reactions that take place on the surface of the red blood cell initiate complement activation true
what does direct anti-globulin testing detect in vivo sensitization of red blood cells
what does indirect anti-globulin testing detects in vitro sensitization of red blood cells
what are the four human blood types A, B, AB , O
what can affect the anti-globulin temperature and medium incubation
what immunoglobulin is capable of crossing the placenta IgG
what is the purpose of the anti-human globulin test in blood banking it detects red cells coated with antibody by bridging the gap between red cells
what immunoglobulin exists in a pentameric configuration IgM
how is the classical pathway of complement activated by binding of antigen with antibody
what are produced after exposure to genetically different non-self alloantibodies
what reagents are used as enhancement medium 1. LISS 2. PEG 3. albumin
phenotype antigen that can be detected in a blood sample
antigen foreign nonself substance causing an immune response
immune response refers to the body's ability to respond to antigen
dosage when an antibody reacts more strongly with and antigen resulting from a homozgous gene expression vs a heterozygous gene expression
genotype gene expression on the chromosomes
gene linkage when two genes located close together on a chromosome are inherited together as a unit
chromosomes double strands of DNA structure which carry the genetic information
heterozygous inheritance of two different alleles
genes small section of a chromosome which contains the DNA which makes us all unique
homozygous inheritance of identical alleles
in vitro reaction occurring inside the body
in vivo reaction occurring outside the body
what is Landsteiner's rule about the ABO system the only system in which the reciprocal antibodies are consistently and predictably present in the Sera of normal people whose RBCs lack the corresponding antigens
where are ABO antigens located on the surface of the RBC
where are ABO antibodies located in the plasma
generally what immunoglobulin class are the ABO system antibodies IgM
what temperature do we perform ABO typing room temperature
what testing medium do we use to perform ABO typing saline
A antigen B antibodies
B antigen A antibodies
A B antigen NO antibodies
O antigen A and B antibodies
the term use to describe the sensitization of an individual's when the an individual no longer recognizes elf and develops antibodies against themselves autoimmunization
the term used to describe the development of antibodies when a person is sensitized either through trans fusion and pregnancy alloimmunization
match the sugar to blood type A=N-acetylgalactosamine and D-galactose O=L-fucose B=D-galactose and AB=N-acetylglucosamine and D-galactose
how should blood bank reagents be stored in the fridge
where are ABH substances in secretors 1. tears 2. saliva 3. urine
what is lectin seed extracts that will agglutinate human ells with moderate specificity
what is the source of anti-A1 lectin dolichos biflorus
why is reverse grouping not performed on cord blood specimens antibodies to the ABO antigens are generally not present at birth
the ABO group antibodies are primarily naturally occurring
what does the hh genotype refer to Bombay
where are Rh antigens located on RBCs
what is the purpose for using check cells ( control cells) with the weak D checks cells help confirm the test is working
Rh antibodies are in what immunoglobulin class IgG
Rh antibodies react best at what temperature 37C
the most immunogenic of the Rh antigen is D
in the Rh blood group system only anti-D can cause hemolytic disease of the newborn false
why don't we do reverse typing when we do Rh typing there is not any antibodies to be checked when doing Rh typing
explain fisher-race theory there are 3 genes located very lose together and each gave rise to its own antigen expression
what is the basis of Rosenfield Rh terminology + or - sign demonstrates the presence or absence of antigen on a red cell
what percentage of the population is Rh negative 15%
why should a weak D person by typed as Rh positive or donor purposes even a slight positive would make the person Rh positive and need Rh positive blood
what is the purpose of the Rh control tube to determine if the blood type is positive or negative
CDe/Cde R1r'
CdE/Cde R2Ro
cDE/cDe ryr'
cde/cde rr
Cde/cdE r'r''
cDE/CDE R2Rz
what are considered anti-globulin dependent blood group systems duffy, kidd, kell
what are considered non-anti-globulin dependent blood group systems MNS, P, I
what are some general characteristics of anti-globulin dependent blood group system antibodies 1. 37C reacting antibodies and are clinically significant 2. require indirect anti-globulin testing for detection and ID 3. can e implicated in hemolytic disease of the newborn
duffy bloody type that shows a resistance to fy (a-b-)
general characteristics of the non-antigobulin dependent blood group system antibodies 1. usually react at room temperature , at immediate spin phase 2. usually not implicated in hemolytic disease of the newborn 3. usually not clinically significant
symbol for Lu Lutheran
symbol for Jk Kidd
expression of the MNSs antigens on a patients RBCs requires how many genes two one from each parent
the p blood group system is as far as inheritance is concerned structurally related to which of the following blood group system ABO system
individuals who are sector possess which of the following genes Se
kell blood group Jka and kb
antibodies implicated in HDN anti-S
blood group associated with delayed transfusion reactions Kidd
antibodies you possible find in a patent with no history of transfusion or pregnancy anti-P1, anti-Lea, and ant-1 - naturally occurring
time limit for specimen viability in blood banking procedure 72 hours
what does it mean when a cell is sensitized when antibody attaches to antigens that are located on the surface of RBCS first step of Ag-Ab reaction
COLD antibodies Lewis (Lea and Leb) P(P1 and P) MNSs (M,N,S,s) Lua is both
WARM antibodies Lutheran (Lua and Lub) Rh ( D,C,E,c,e) Kell (K,k) Duffy (fya and Fyb)
List the IgM antibodies Anti-Lea, Anti-Leb, Anti-I, Anti-P1 Anti-M Anti-N, Anti-Lua (also IgG)
list the IgG antibodies Rh antibodies, Kell, Duffy, Kidd, S,s, Anti-Lua (alo IgM) Anti-Lub
blood group antigen destroyed by enzymes Fya an Fyb, M, N, S, s
Antibodies that who dosage Anti-M, Anti-N, Kidd, and Duffy
which antibodies are enhanced by enzymes Kidd, Rh, Lewis, I, P
Fisher-Race nomenclature Ro/cDe R1/CDe R2/cDE Rz/CDE r/cd r'/Cde r''/cdE ry/CdE
Created by: marcheta
 

 



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