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naplex

DM

QuestionAnswer
metformin/sitagliptin Janumet, Janumet XR
saxagliptin/dapagliflozin Qtern
liraglutide/insulin degludec Xultophy
lixisenatide/insulin glargin Soliqua
glipizide Preferred sulfonyluria in renal insufficiency, Contraindicated in sulfa allergy
glyburide Can be used in pregnancy
Drug combination that severely increase risk of hypoglycemia Insulin, sulfonylurea, and meglitinide
pioglitazone Actos
pioglitazone contraindications HF, NYHA III/IV
canagliflozin Invokana
canagliflozin BBW increased risk of amputations
SGLT2 eGFR contraindication <30ml/min
empagliflozin Jardiance
What SGLT2 inhibitor can cause hyperkalemia? canagliflozin
What drug reduce CV events metformin, empagliflozin, liraglutide
sitagliptin Januvia
saxagliptin Onglyza
linagliptin Tradjenta, no renal dose adjustment
What risk increase use of saxagliptin and alogliptin? HF
Major substrate of CYP3A4 and P-gp saxagliptin, linagliptin
exenatide Byetta
liraglutide Victoza
dulaglutide Trulicity
Albiglutide Tanzeum
lixisenatide Adlyxin
started total dose of insulin per day 0.6u/kg/d
who is tested for diabetes BMI >25 + 1 risk (AIC :5.7 etc.)
retinopathy screening every 2 years
neuropathy screening annually with 10g monofilament + another test
1st line neuropathy agents duloxetine and pregabalin
vaccinations flu + pneumovax + at 65 prevnar + pneumovax in 1 year (at least 5 years from the previous dose) HepB (19-59 y.o.)
drugs that raise BG systemic steroids b blockers loop and thiazide diuretics immunosuppressants (cyclosporin, tocrolimus) niacin PIs quinolones atypicl antipsych (clozapine, olanzapine, quetiapine) statins
Glucovance metformin/glyburide
Xigduo metformin/dapagliflozin
meglitinides meal relation Should be taken 30 min before meals
pramlintide Reduce insulin dose by 50%
Novolog, Novolog Flexipen aspart, rapid-acting insulin
Apidra, Apidra Solostar glulisine, rapid-acting insulin
Humalog, Humalog Kwikpen lispro, rapid-acting insulin Humaloh Kwikpen comes in U-100 and U-200
affreza is contraindicated COPD, Asthma
Humulin R, Novolin R regular insulin, short-acting regular insulin
Humulin R U-500, Novolin R Kwikpen concentrated regular insulin
Humulin N Humulin N Kwikpen Novolin N NPH, intermediate-acting insulin
Levemir, Levemir Flextouch Detemir, long-acting insulin
Lantus Lantus Solostar Basaglar Kwikpen Toujeo Solostar (U-300) Glargine, long-acting insulin
Tresiba Flextouch degludec, long-acting insulin comes in U-200
correction factor for 1 unit of rapid insulin 1)1800/total daily units 2) BG - target BG/correction factor
correction factor for 1 unit of regular insulin 1)1500/total daily units 2) BG - target BG/correction factor
converting NPH to Lantu 80% NPH
Toujeo to Lantus 80% toejeo
hypoglycemia BG < 70
Target BG for hospitalized patients 140-180
Drugs that can cause hypoglycemia Linezolid lorcaserin (Belviq) Quinolones quinidine pentamidine propranolol octreatide
DKA BG >250 PH <7.35 anion GAP >12 ketones in urine
Hyperglycemia hyperosmolar State (HHS) BG >600 Extreme dehydration pH > 7.3, bicarbonate >15mEq/L
DKA tx 1) Fluids: NS when BG 250 - D5W1/2NS 2) Regular insulin 1U/kg/hr 3) Monitor K 4) If ph <7 - treat with sodium bicarb
eGFR<30, do not use metformin exenatide SGLT2 inhibitors
HF TZDs alogliptin saxagliptin
G6PD deficiency sulfanylurias
hepatotoxicity alogliptin TZDs
ketoacidosis SGLT2
pancreatitis GLP1 DPP4
thyroid cancer GLP1
bladder cancer TZDs
dehydration /hypotension SGLT2
Created by: anivanova
 

 



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