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Chapter 9-12 test
| Question | Answer |
|---|---|
| Lymphocyte comcentrations in peripheral blood are greatest during what age interval? | Immediately after birth |
| The "migrating pool" of neutrophils is located: | On the blood vessel walls |
| To calculate absolute leukocyte counts: | # of WBCs x's 1000 x's percentage of whichever type of leukocyte |
| CD markers associated with the myelocyte: | CD45, CD33, & CD13 |
| One of the primary glands responsible for lymphocyte origination in the infant is the: | Thymus gland |
| The initial appearance of specific granulation in the granulocytic series is predominately seen in | Myelocyte |
| The amount of time a granulocyte spends in the circulation before migrating into the tissues is normally: | 48 hours |
| What is the definition of delta check? | Comparison to previous results |
| List features of ths lymphatic system | Blood filtration, antibody generation, and lymphopoiesis. |
| How many maturation stages are in the neutrophil? | Five |
| The N:C ratio in a myeloblast is: | 4:1 |
| The plasma cell is responsible for: | Humoral immunity |
| Most lymphocyte subpopulations are recognized by their CD markers. CD refers to: | Cluster designation |
| How many of the white blood cell population does the spleen harbor? | 1/4 |
| What can be seen on a peripheral smear on a 17-year-old boy admitted to thw hospital with a fever of unknown origin? His WBC count is 20.0 ×10 to the ninth/L. | Toxic granulation, increased band neutrophils, dohle bodies. (Not reactive monocytes) |
| A typical blood picture in infectious mononucleosis is: | An absolute lymphocytosis w/o anemia, and many reactive lymphocytes. |
| Opsonization of foreign bodies is: | Preparing foriegn bodies for phagocytosis. |
| A patient who presents with a low WBC, thrombocytopenia, elevated liver enzymes, and mulberry-like inclusions in the granulocytes is most likely suffering from: | Himan Ehrlichiosis |
| Mention mechanisms by which neutropenia is usually produced: | Decreased production by the bone msrroe, impaired release from the bone msrrow to the blood, and increased destruction. (Not bacterial infections) |
| What is true about most lipid storage diseases? | They are caused by a missing metabolic enzyme. |
| Which is the autosomal disorder that manifests itself with large lysosomal inclusions, recurring infections, and albinism? | Chediak-Higashi syndrome |
| Unusual complication that may occur in infectious mononucleosis is: | Hemolytic anemia |
| What is the best corrective action for a patient who exibits platelet satellitism on peripheral blood smear? | Recollect the specimen in a sodium citrate tube |
| A patient who has a persist leukocytosis, dihle bodies, and an elevated LAP score most likely has: | Leukemoid reaction |
| Toxic granulation in neutrophols is a direct result of: | Enhanced lysosome enzyme production |
| Pelger-Huët anomaly is characterized mainly by: | Hyposegmentation of the nueclus in the neutrophils |
| Dohle bodies consist of: | Ribosomal RNA |
| Gray-green cytoplasm granules in the neutrophils will be seen in: | Chediak-Higashi syndrome |
| Normal ratio of CD4 to CD8 lymphocytes is: | 2:1 |
| List lipid storage syndromes/diseases. | Gaucher's disease, Tay-Sachs disease, and Neimann-Pick disease. (NOT Chediak-Higashi syndrome) |
| The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes: | Replacement of normal marrow precursors by leikemic cells, decrease in functional leukocytes causing infection, and hemorrhage secondsry to thrombocyhtopenia. (NOT decreased erythropoietin production) |
| Migration to extramedullary sites is a feature of wgich leukemia? | Acute myelocytic leukemia |
| A patient with generalized lymphadenopathy and a WBC of 100 x 10 to the ninth/L. This hematologic picture would most likely be seen in: | Chronic lymphocytic leukemia |
| A patient with AML is likely to have a cytochemical stain panel that is positive for: | MPO, SBB, and Specific esterase |
| Monoclonal marker that is often positive in T-ALL: | CD7 |
| The t(15:17)(q22;q12) is associated with which leukemia? | Acute promyelocytic leukemia |
| The WBC count is 20x 10 to the ninth/L, with 89% blasts, 7% segs, and 4% monos. The blasts are relativeky large and have abunant cytoplasm. More than 90% of them are positive with the NSE stain, and an occasional blast is positive with Sudan Black B. | What is the possible diagnosis? ANLL, TypeM5 |
| The L3 classification of leukemia is defined by: | Large vacuolated blasts |
| What are acute leukemic processes marked by? | Rapid onset anemia and thrombocytopenia |
| Characteristic of Auer rods: | Composed of fused primary granules |
| What is the pattern if when performing flow cytometry, the technologist interpreted the flow pattern as exihibting a high degree of CD14 and CD4 positive cells. The peripheral smear showed large multilobulated blast cells. | AMonoL |
| CD marker that best represents the earliest progenitor cells. | CD34 |
| According to current WHO classification criteria, acute leukemia is characterized by: | Hypercellular bone marrow with greater than 20% blasts. |
| Pure erythroid leukemia is defined as: | Eyrthroid precursors greater than 80% |
| The leukemia with a predominance of WBC cells positive for CD41 is: | AMegL |
| Rsrest form of the AMLs is: | M7 |
| The presence of CD2, CD5, and CD7 and the absence of CD10 is seen in: | T-lymphocytes |
| Predominately a disease in children is: | ALL |
| How many of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL? | 20% |
| Pedistric patients with ALL have an overall complete remission rate of: | 95% |
| Low-risk ALL pediatric clinical trials require the WBC count to be: | 50 x 10 to the ninth/L |
| What may arise as a blastic transformation in patients with CML? | Acute lymphocytic leukemia |
| Tyrosine kinase is an important mediator in leukocyte metabolic pathways because: | It supresses Apoptosis |
| Term that describes a peripheral blood finding of leukocytosis with a shift to the left accompanied by occasional nucleated red cells and platelet abnormalities: | Leukoerythroblastic |
| What is the accelerated phase of chronic myeloid leukemia marked by? | Increased basophils |
| Pantocytosis is a prominent feature of which disorder? | Polycythemia Vera |
| What is the pathophysiology of the myeloproliferation disorders? | Neoplastic transformation of multipotential stem cells. |
| Myecardial infarctions, transient ischemic attacks, and deep vein thrombosis are likely to be complications of: | Myelofibrosis with myeloid metaplasia |
| A "dry tap" is a characteristic od myeloid fibrosis with myeloid meyaplasia due to: | Increased infiltrstion of fibrotic elements |
| What effect does the Ph chromosome have on the prognosis of patients with chronic myelocytic leukemia? | The proignosis is better if the Ph chromosome is present. |
| The red cell morphology associated with IMF is: | Teardrop cells |
| The LAP stain is helpful in distinguishing: | A leukemoid reaction from CGL. |
| a high-risk factor for the diagnosus of essential thrombocythemia is: | A platelet count of greater than 600,000 |
| What is associated with CML but not AML? | Splenomegaly |
| List causes of secondsry erthrocytosis. | Hypertension, alcohol, and smoking (NOT SLEEP APNEA) |
| How do you calulate the LAP score on a blood smear? | Add the scores for the 100 neutrophils counted. |
| The translocation of genetic material, t(9:22), is associated with: | The philidelphia chromosome |
| What indicates the transformation of a chronic process too an acute process? | An increase in the percentage of blasts in the peripheral blood or bone marrow |
| What is true regarding a leukemoid reaction? | Increased toxic granulation, increased dohle bodies, shift to the left on neutrophils. (ANEMIA IS NOT USUALLY PRESENT) |
| Plethora is: | |
| A condition associated with polycythemia Vera | |
| The JAK2 chromosomal mutation is associated with: | Polycythemia Vera |
| Which of the myleoproliferative disorders has the worst prognosis? | Idiopathic myleofibrosis |
| List causes of thrombocytosis: | Malignancy, blood loss, and infection (NOT SMOKING) |
| The main cell line affected by essential thrombocytosis is: | Megakaryocytes |
| Chronic myelogenois leukemia will present with how many blasts in the peripheral blood? | 5% |
Created by:
Mzapril352