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UCONN epigenetics
test 1
| Question | Answer |
|---|---|
| SWI/SNF | mutants affect expression of budding yeast that encodes fermentation of sucrose to glucose and fructose. can evict DNA bulging |
| CHD | Repressive or activating evict |
| ISWI | Regulatory spacing nucleosomes to promote transcriptional repression. Slide to assist RNAP2. No evict |
| INO80 | Promotes transcriptional activation and DNA repair. Can remove H2A-H2B and replace with H2A.Z-H2B dimers |
| Bromodomain | AC |
| Chromodomain | Meth |
| Activating mods | H3K18AC H3K4me H3K36me |
| Repressive mods | H3K27me H3K9me |
| H3K27me | repressive EZH2 Pc(chromo) |
| H3K9me2 | repressive Su(var)3-9 HP1 (chromo) Pericentric hetero |
| H3k18Ac | Activating HAT Swi/Snf or pCAF bromo |
| H3K4me | Activating set1 CHD1 Promoter |
| H3K36me | Activating Set2 EAF3 Across body and 3'end |