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Humidity/ aerosol

QuestionAnswer
What are the four types of hypoxia? Hypoxic hypoxia, anemic, circulatory, histotoxic
Hypoxic hypoxia? Low arterial oxygen tension(PaO2) in blood
Causes of hypoxic hypoxia? Hypoventilation, high altitude, diffusion impairment, ventilation perfusion mismatch, interstitial fibrosis, pulmonary something, interstitial lung disease, pulmonary Edema
Anemic hypoxia? PaO2 is normal, but the oxygen carrying capacity of the hemoglobin is in adequate
Causes of anemic hypoxia? Decreased hemoglobin concentration leads to anemia or hemorrhage; abnormal hemoglobinleads to carboxyhemoglobin 250 times greater and mehmoglobin
Circulatory hypoxia? Blood flow to the tissue cells is inadequate; Slow or stagnant pooling of peripheral blood flow
Causes of circulatory hypoxia? Blockage, slow stagnant pooling of blood, arterial venous shunts
Histotoxic hypoxia? Impaired ability of the tissue cells to metabolize oxygen
Causes of histotoxic hypoxia? Cyanide poisoning
Define aerosol? Hey suspension of solid, liquid, particles in a gas
Define humidity deficit? A condition in which available humidity is less than potential humidity, percent relative humidity less than 100
Define absolute humidity? Actual mass or content of water in a measured volume air, usually expressed in grams per cubic meter or pounds
Define relative humidity? Amount of moisture in the air compound with maximum, the air could contain at the same temperature
Define humidifier? A device that adds invisible molecular water to gas
Define humidity? Water vapor that exist in the form of individual molecules in the vaporous or gaseous state
Define saturated gas? A solution in which the solute contains maximal of solute it can take up
Define BTPS? Abbreviation for body temperature, ambient pressure, saturated with water vapor
Define ISB? Point at which the inspired air reaches BTPS
Define Brownian diffusion? Random movement of molecules/particles caused by the molecules being struck by other molecules particles
Define inertial impaction? Medication impacts and deposits on airway walls
Define refractory hypoxemia? Oxygen therapy/level of oxygen does not respond to treatment
List the calculations of LOX? 1 L of LOX=860 L of gaseous oxygen 1 L of LOX=2.5 pounds 1 pound LOX=344 L of gaseous oxygen
List the tank factors? H/K-3.14; G-2.41; E-0.28
What is the primary function of the upper respiratory tract? During inspiration tortuous flow through the nose insurers adequate contact between inspired air and mucosa
What are the hazards of breathing anhydrous dry gas? Retain secretions, mucus plugging
How much water per day do our lungs contribute to saturate inspired gas? 250 mL per day water is contributed by the lungs to saturate inspired gas
What are the indications of humidity therapy? Upper airway edema, Croup, Epiglottitis, post extubation Edema, bronchial hygiene, sputum induction
What are the hazards associated with humidity therapy? Wheezing and bronchospasm, swelling of inspissated secretions, infection, overhydration, airway burns, caregiver exposure
What are the indications for warming inspired gases? Atelectasis, dry nonproductive cough, increased airway resistance, increased incidence of infection, take dehydrated secretions, increased work of breathing, patient complained of substernal pain in airway dryness
What are the indications for cool bland aerosol? Presence of upper airway edema
What are the three main types of humidifiers? Bubble, Passover, heat moisture exchanger
How does bubble humidifier work? A humidifier breaks/defuses an underwater guestroom into small bubbles 15/20mg/l
How does Passover humidifier work? Directs gas over a surface containing water
How does a heat moisture exchanger humidifier work? Passive humidifier/artificial nose, no heat/water added to system, captures exhaled air heat and moisture
How long can you use a heat moisture exchanger humidifier for? Short term up to 96 hours
What type of humidifier is most suitable for a nasal cannula and what liter flow is humidity required? Bubble humidifier with the nasal cannula
What are the indications for aerosol therapy? Upper airway edema, laryngotracheobronchitis, subglottic edema, post extubation edema, post operative management of upper airway, bypassed upper airway, sputum metabolization of secretions
What are the hazards of associated with aerosol therapy? Wheezing, bronchospasm, bronchoconstriction when artificial airway is views, infection, overhydration, patient discomfort
What is the primary method of disposition of particles <3um? Brownian movement
What is the primary method of disposition of particles>5um? Inertial impaction
What is the ideal particle size for lower airway desposition? Alveolar desposition? Lower airway 2 to 5 Alveoli 1 to 3
Which bronchodilators are delivered via aerosol?
Xanthines
What are the two main types of nebulizers? Jet/SVN; ultrasonic
How does a standard SVN work?
Air in trained across the top of device, they lose aerosol produced within the nebulizer, exit toward patient. Aerosol generated 30 to 60% nominal dose is residual volume trapped
How does an SVN with aerosol collection bag work? Bag reservoir holds the aerosol generated during acceleration and allows a small amount of particles to remain in suspension for the next inhalation. Well larger particles 30 to 50% increase inhaled dosage
How does a breath enhanced SVN work? aerosol continuously, system of one-way valves, minimize aerosol waste. Inspiratory vent allows patient to draw air through nebulizer chamber generating & containing aerosolized drug, inlet vet closes, Aerosol exits oneway valve, increase inhaled mass 50%
How does a breath actuated SVN work? Generates ever so based on patient's breathing pattern, during inspiration. Eliminates wasted aerosol during exhalation & increases the delivered dose threefold or more over. Continuous and breath enhance nebulizer
How does a GIN nebulizer work? Hi output with wide variety of oxygen concentration
How does a USN nebulizer work? Piezoelectric crystals generate an aerosol. Crystal transducer converts electrical signal into high frequency acoustic vibrations focused on the liquid above transducer, disrupts the surface & creates oscillation waves. breaks into fine aerosol particles
What is the most common hazard associated with inhaled corticosteroid's? Thrush, fungal infections
What medication is delivered by a Spag? Ribavirin=virazole used to treat RSV
What is the brand name for Dornase Alfa? Pulmozyme
What is the brand name of Cromolyn sodium? Intal
What is the brand name for budesonide? Pulmicort
What is the ideal body position and breathing pattern for an SVN? Upright/Fowlers position. Read normally with occasional deep breath's at the end of inspiratory, hold for 3 to 5 seconds. Breath hold improves deposition of drug making it more effective
What is the ideal body position and breathing pattern for an MDI? Hold inhaler 1 to 2 inches/2 fingers in front of mouth, read slowly through mouth and press down on inhaler once. Take deep breath, hold for 10 seconds exhale normally
What is the ideal body position and breathing pattern for a DPI? Upright. Remove cap load medication if lever then slide or twist until click, turn head exhale, close lips firmly around dpi, inhale as deeply as possible, remove mouth and hold breath for 10 seconds
What is the purpose of the breath hold during a breathing treatment? Improves disposition of drug making it more effective
What aerosol delivery devices are used with nebulizers? Aerosol mask; face tent, T piece adapter; trach collar or mask
What is the purpose of priming an MDI? Provide a precise metered dose of medication in a fine mess directly into the airways
What is the purpose of a spacer? Increases the effectiveness of disposition and improves medication delivery
How does an MDI work? Medication is pushed out my propellant
How does a DPI work? Medication is self-propelled due to patient's inspiration breath
What are the advantages of using a DPI? Small and portable, built-in dose center, propellant free, breath actuated, short preparation and administered time
What is the most common dosage for an MDI? 100 to 200um
What are the brand names of the DPI drugs? Serevent, brovana, foradil, spiriva
How do you clean and disinfect and SVN? Disassemble nebulizer, wash in warm soapy tapwater. So cup & mouthpiece one hour in one part vinegar 5%, three parts hot water 1.25% acetic acid. Rents nebulizer with sterile water. Shake, air dry on towel. Disinfectant wipes on compressor
Define bronchoconstriction? Condition in which the lumen of the airway is decreased or constricted do to bronchospasm, mucosal edema, secretions
What are the three types of bronchoconstriction? Bronchospasm, mucosal edema, secretions
What drug types are used to treat the three types of bronchoconstriction? Bronchodilator, corticosteroids, mucolytic's
What are the sympathetic receptor sites? Alpha, beta 1, beta 2
What are the effects of stimulating the alpha receptor site? Vasoconstriction, vasopressor effect= increase blood pressure
What are the effects of stimulating the beta one receptor site? Increased heart rate, increased force contractibility
What are the effects of stimulating the beta two receptor site? Relaxes bronchial smooth muscle
What is the SVN dosage for Ventolin? 0.5 mL of a 0.5% solution (2.5mg) 0.4-0.5
What is the SVN dosage for levalbuterol? 0.63 mg/3 mL TID 1.25 mg/3 mL TID
What is the brand name for acetylcysteine? Mucomyst
What is the mode of action for acetylcysteine? Reduce is viscosity of mucus by breaking disliquified bonds
What are the percent solutions for acetylcysteine? 10% and 20%
What are corticosteroids used to treat? Anti-inflammatory maintenance therapy of persistent asthma and severe COPD
What are the advantages of aerosolized corticosteroids , In contrast to systemic? Fewer side effects than systemic use, no adrenal suppression or Cushing's syndrome, low risk dependency
What are the adverse affects that can occur with aerosolized steroids? Greater expense then oral, not helpful in status asthmaticus, increased risk of infection
What is the mode of action for cromolyn sodium? Prevents degranulation or break down by thickening of mast cells, prevents release of histamine and other inflammatory mediators
What is cromolyn sodium used to treat? Prophylactic for asthma
What is the appropriate flow range for an SVN? 5 to 10 mL per minute
What is the composition of pulmonary surfactant? 85% phospholipids, natural lipids, proteins
What is the function of pulmonary surfactant? Reduce surface tension, increases pulmonary compliance, prevents alveolar collapse
What is the production of pulmonary surfactant? Yawning or big sighs stimulate pulmonary surfactant production
List the brand/generic names for surfactant replacement drugs? Beractant=survanta Calfactant=infasurf Proactant Alfa=curosurf
What solutions are used for bland aerosol (wetting agents)? Isotonic/normal saline=0.9% Hypotonic saline=0.45% Hypertonic saline=3% Sterile/distilled water
Define body humidity? Absolute humidity in a volume of gas saturated and a body temperature of 37°C equivalent to 43.8 mg/L of water in the air
Define capillary action? A phenomenon in which a liquid in a small tube moves upward against gravity
Define evaporation? Process by which liquids change into a weber state. This occurs because of the changes in temperature, pressure, vapor pressure gradients
What is the primary goal of humidity/bland aerosol therapy? Maintain physiological conditions in lower airways. Supply increased levels of humidity, anhydrous dry medical gases
What are the indication for humidity/bland aerosol therapy? Upper airway edema, bypassed upper airway, croup, Epiglottitis, post extubation edema, need for speed him or mobilization of secretions
Where is the ISB normally located? 5 cm below the Carina
What factors can cause the ISB to shift? Breathing through the mouth instead of nose, cold/dry air, upper airway is bypassed, higher minute ventilation
How are temperature and humidity affected above the ISB? Temperature and humidity decrease during inspiration and increase during expiration
How are temperature and humidity affected below the ISB? Temperature and humidity remain constant
What are the hazards of inhaling dry gas? Atelectasis, dry nonproductive cough, increased airway resistance, increased incidence of infections, increased work of breathing tube, substernal pain, airway dryness, dehydrated secretions
What are the three factors that affect the quality of a humidifier's performance? How does each factor affect the performance? Increase temperature= increase capacity for water vapor Increase surface area=Increase evaporation Increase contact Time=Increase evaporation Increase flow=Decrease time for evaporation to occur
What are the contradictions of humidity/bland aerosol therapy? Bronchoconstriction, history of airway hyperresponsiveness
What is the liter flow when adding humidity to a nasal cannula? 4 L per minute
What humidifier is referred to as an artificial nose? Heat and moisture exchanger
How long can a heat moisture exchanger be used for? Up to 96 hours
Define centrifugal force? Apparent force that acts out word on a body moving around a circle
Define condensation? Change of state from a gas to a liquid, as with water vapor condensation
Define dewpoint? Temperature at which water vapor condenses back to with liquid form
Define convection? Heat transfer through the mixing of liquid molecules at different temperatures states via thermal currents
Define Water vapor pressure? The pressure exerted by water and it's gaseous state
Define insensible water loss? Evaporation of water from the lungs and skin
Define saturated? Solution in which the solute contains max amount of solute it can take up
Define supersaturated? When solve it contains more solution then a saturated solution at same temperature and pressure
Define inspissated? Dried, heavy, Intense/fluid thickened or harden through the absorption or evaporation of the liquid portion, as can occur with respiratory secretions win the upper airway is bypassed
Define contamination? Condition indicating the presence of undesirable or accidentally introduced organisms
Where are the adrenergic receptors located within the nervous system? Sympathetic nervous system
What is the action of cAMP? Promotes bronchodilation
Where are the cholinergic receptors located within the nervous system? Parasympathetic nervous system
What is the action of cGMP? Promotes bronchoconstriction
Do parasympatholtic bronchodilators indirectly or directly bronchodilator? Now describe how exactly they cause bronchodilation Indirectly, cAMP causes bronchoconstriction
Do sympathomimetic bronchodilators indirectly or directly bronchodilator? Now describe how exactly they cause bronchodilation. Directly, increase cGMP causes bronchodilation
Name the two types of cholinergic receptors? Acetylcholine, muscarnic
Give at least one other name for parasympatholytic medication? Anti-cholinergic, back door
List the two aerosolized parasympatholytic used as bronchodilator; brand and generic names? Ipratropium bromide=atrovent Tiotropium bromide=spiriva
Give at least one other name for sympathomimetic medications? Adrenergic bronchodilator/front door bronchodilators
List the two main ultra short acting beta agonist medication; brand name and generic names? Epinephrine Racemic epinephrine=micronefrine,vaponefrine,nephron
List the three main short acting beta agonist medications; brand names and generic names? Levalbuterol=xopenex Albuterol=proventil,ventolin,ProAir,AccuNeb,vaspine Metaproterenol=xxxxx
List the three main long acting beta agonist medication; brand names and generic names? Salemeterol=serevent Arformoterol=brovana Formoterol=foradil, perforomist
Which classification of drugs is referred to as front door meds ? Back door meds? Side door meds? Sympathomimetic=front door Anticholinergic=back door Canthines=side door
What recently replaced be Combivent MDI? Respimat
What to medications are in Combivent? Albuterol, ipratropium bromide
List to Mucolytics and their brand names. State which one is used for cystic fibrosis patients? N acetylcysteine=mucomyst Dornase alfa =pulmozyme is used for cystic fibrosis patients
What is the difference between a rescue medication and a controller medication? Rescue is for emergency Controllers for long-term maintenance
What is the mode of action for xanthines? Promotes smooth muscle relaxation
Name three xanthines? Theophylline=theodur Aminophylline=xxxx Caffeine citrate=cafcit
What is caffeine citrate used to treat? Used for apnea of prematurity
Name to inhaled corticosteroid's; generic and brand-name is? Fluticasone=flovent Budesonide=pulmicort
What drug is given with the respirgard II nebulizer and what is it used to treat? Pentamidine isethinate=NebuPent-treats pneumocystis jeroveci(pneumonia caring) in aids patients
Can a corticosteroid be mixed with a bronchodilator? Yes
Corticosteroids generic name is typically end in what three letters? One, ide
Why should Mucomyst be mixed with a bronchodilator? To remove thick secretions
Can Pulmozyme be mixed with a broncodilator? No
What to drugs make up Advair? Fluticasone, salemeterol
What to drugs make up Symbicort? Budesonide, formeterol
What type of solution is used for sputum induction? Hypertonic solution
What type of patient will be given surfactant? Infants less than 28 weeks
Particle sizes of 1 to 3 micron will generally deposit in what area of the lungs? Alveolar region
Particle sizes of 2 to 5 µm will generally deposit and what area of the lungs? Lower airways
With what devices are therapeutic aerosols generated? Atomizer, nebulizer
The mass of aerosol particles produced by a nebulizer in a given unit time best describes which quality of the aerosol? Outfit
What describes the mass of drug leaving the mouthpiece of a nebulizer as aerosol? Emitted dose
What measure is used to identify the particle diameter, which corresponds to the most typical settling behavior of an aerosol? Mean mass aerodynamic diameter MMAD
What is the retention of aerosol particles resulting from contact with the respiratory tract mucosa called? Deposition
What factors affect pulmonary deposition of an aerosol? Size of the particles, shape and motion of the particles, physical characteristics of the airways
What is the primary mechanism of Deposition of large, high mass particles greater than 5 µm in the respiratory tract? Inertial impaction
What will increase aerosol deposition by inertial impaction? Variable or irregular passages; turbulent gas flow; High velocity gas flow; particles of high mass
Where do most aerosol particles in the 5 to 10 µm range deposit? Upper airways
What is the primary mechanism for central air way deposition A particles in the 1 to 5 µm range? Sedimentation
Where do most aerosol particles in the 1 to 5 µm range deposit? Central airways
What technique will increase aerosol deposition of small particles? 10 second breath hold
What is the primary fate of inhaled aerosol particles that are between 1 and 0.5 µm? Most are clear during exhalation
A physician wants to deliver a therapeutic aerosol to the upper airways. To help ensure maximum de position in this area, you would select an aerosol generator with an MMAD in what range? 5 to 50 µm
If position wants to deliver a therapeutic aerosol to the central and lower airways. To help ensure maximum Deposition in this area, you would select an aerosol generator with an MMAD in what range? 2 to 5 µm
If position wants to deliver a therapeutic aerosol to the lung parenchyma. To help ensure maximum deposition in this area, you would select an aerosol generator with an MMAD and what range? 1 to 3 µm
To minimize the risk of infection associated with aerosol drug therapy, what should you do? Sterilize nebulizers between patients, frequently replace in use units, rinse nebulizers with sterile water
What is the preferred method for delivering bronchodilators to spontaneously breathing and intubated, ventilated patients? Metered dose inhaler
Most of the spray generated by the majority of metered dose inhaler's consist of what? Propellant
When fired inside the mouth, what percentage of the drug does delivered by a simple metered dose inhaler deposits in the oropharynx? 80%
When using a metered dose inhaler without a holding chamber or a spacer, the patient should be instructed to fire the device at what point? Immediately after beginning a slow inspiration
To ensure delivery of a proper drug dosage with a meter dose inhaler, what must be done to it before its use? The canister should be warm to head or body temperature, canister should be vigorously shaking
What group of patients are most likely to have difficulty using a simple metered dose inhaler for aerosol drug therapy? Patients in acute distress, infants and young children, elderly persons
What agent has been associated with increased intraocular pressure? Anti-cholinergics
To decrease the likelihood of an opportunistic yeast or fungal infection associated with a meter dose inhaler steroids,what would you recommend that a patient do? Use a spacer or holding chamber, rinse the mouth after each treatment
The key difference between a metered dose inhaler holding chamber and a spacer is that the holding chamber incorporates what? One way inspiratory Valve
After actuating a metered dose inhaler with a holding chamber, what should the patient be instructed to do? Continue to breathe through the device for three breaths
What devices would you select to deliver an aerosolized bronchodilator to a young child? MDI, holding chamber, mask
Proper use of a dry powder inhaler requires that the patient be able to do what? Generate inspiratory flows of 60 L per minute or higher
What patient groups is the use of a dry powdered inhaler for broncodilator administration not recommended? Infants and children younger than five years of age; patients with an acute bronchospastic episode
Exhaling into what device can result in the loss of drug delivery? Dry powder inhaler
What design features affect the performance of a small volume jet nebulizer? Position, residual value, baffles, reservoirs
What is the average amount of dead volume in a small volume jet nebulizer after the device runs dry? 0.5 to 2.2mL
What happens as the pressure or flow delivered through a small volume jet nebulizer gets higher? Treatment time become shorter, particle size become smaller, aerosol output becomes greater
Normally, when using a 50 psi flowmeter to drive a small volume jet nebulizer, to what should you set the nebulizer flow 6 to 10 L per minute
To minimize a patient infection risk between drug treatments with a small volume jet nebulizer what should you do? Rinse the SVN with sterile water; air dry
What is the point in the respiratory tract where inspired gas reach his body temperature, ambient pressure, saturated BTPS conditions? Isothermic saturation boundary
What factors can cause the Isothermic saturation boundary to shift farther down into the airways? Decreased ambient temperature, increase tidal volume, endotracheal intubation
Administration of dry gas is at flows exceeding 4 L per minute can cause what? Structural damage, heat loss, water loss
Inhalation of dry gases can do what? Increase viscosity of secretions, impair mucociliary motility, increased airway irritability
What inspired conditions should be maintained when delivering medical gases to the nose or mouth? 50% relative humidity at 20°C to 22°C
What inspired condition should be maintained when delivering medical gases to the Hypopharynx, as when administering oxygen by nasal catheter? 95% relative humidity at 29°C to 32°C
What inspired conditions should be maintained when delivering medical gases directly into the trachea through an endotracheal tube or a tracheotomy tube? 100% relative humidity at 32°C to 35°C
What is the most important factor determining a humidifier's performance? Temperature
The greater the temperature of the gas, the_? More water vapor it can hold
Gas leaving and unheated humidifier at 10°C and 100% relative humidity/absolute humidity 9.4 mg/L would provide what relative humidity at body temperature? 20%
What is the simplest way to increase the humidity Output of a humidifier? Increase the temperature of either the water or the gas
What is a common way to increase the surface area ratio of humidifiers? Generate a water droplet aerosol, expose the gas to a saturated wick, use a bubble or diffusion head
What type of humidifiers are used in clinical practice? Heat moisture exchanger, passover humidifier, bubble humidifier
Simple unheated bubble humidifiers are commonly used to humidify gases with what type of system? Oronasal oxygen delivery
What is the goal of using an undefeated bubble humidifier with Oronasal oxygen delivery system? Raise the humidity of the gas to ambient levels
What is the typical water vapor output of an unheated bubble humidifier? 15 to 20 mg/L
Increasing the flow through an unheated bubble humidifier has what affect? Decreasing the water vapor content
I'm heated bubble humidifiers are I have a limited effectiveness at flows a bubble what? 10 L per minute
Why should you not heat the reservoirs of a bubble humidifier use with oro nasal oxygen delivery systems? Condensate will obstruct the delivery tubing
The relief valve on a bubble humidifier serves as what function? It indicates Winflo has been interrupted, protects the device from pressure damage
To protect against obstructed or kinked tubing, simple bubble humidifiers incorporate what? Pressure relief valve
The typical pressure pop up incorporated in most simple bubble humidifiers releases pressure above what? 2psi
When checking an oxygen delivery system that incorporates a bubble humidifier running at 6 L per minute, you occlude the delivery tubing, and the humidifier pressure relief immediately pops off,what does this indicate? Normal, leak free system
Add high flow rates, what do you some bubble humidifiers produce? Aerosol particles
What are the three types of Passover humidifiers? Simple reservoir, membrane, wick
A design that increases surface area and enhances evaporation by incorporating in absorbent material partially submerged in a water reservoir that is surrounded by a heating element best describes what type of humidifier? Wick
Which type of humidifier traps the patient's body he ate expired water vapor to raise the humidity of the inspired gas? Heat moisture exchanger
Heat moisture exchangers are mainly used to do what? Warm air humidifier gases delivered to the trachea via ventilator circuits
A heat moisture exchanger has an efficiency rating of 80%. What does this mean? Of the Exhaled the water vapor, 80% returns to the patient on inspiration
The ideal he moisture exchanger should have an efficiency rating of at least what? 70%
What patients should receive heated humidifier therapy? Patients receiving long term mechanical ventilation, patient receiving oxygen through a bypassed upper airway
Created by: Ashlo29
 

 



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