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SSRI

QuestionAnswer
Celexa Citolopram
Lexapro Escitalopram
Prozac, Prozac weekly, Sarafem Fluoxetine
Luvox fluvoxetine, for OCD only
Paxil Paroxetine
Zoloft Sertraline
5HT1, 5HT2, 5HT3 effects 5HT1: depression, 5HT2-sexual dysfxn, 5HT3-GI SEs.
SSRI and Bleeding 5HT required for Plt aggregation, SSRI incre GI bleeding similar to NSAID, used together incre risk of GI bleeding. Luvox and celexa less bleeding
SSRI SEs Activating(fluoxetine)or sedating(fluvoxetine), GI, Sex dysfxn, HA, Hypo-Na, Anticholinergic (Paroxetine only)
Long t1/2 SSRI Fluoxetine, d/c MAOI 2 weeks prior to fluoxetine, d/c fluoxetine 5 weeks prior to MAOI.
Sarafem dose fluoxetine, start 14 days b4 mens, initial 20mg/d; max 80mg/d
Prozac Weekly strength 90mg ER cap, equal to 20mg QD, dose = 1 cap QW start 7 days after last daily dose of fluoxetine.
Prozac weely indication MDD only
fluoxetine indication MDD, OCD, PMS. Sarafem-PMS, Prozac weekly-MDD
Paroxtine strength Paxil: 10,20,30,40mg. Paxil CR: 12.5, 25, 37.5mg
SSRI used for Bulimia nervosa Fluoxetine
Celexa indication MDD
Lexapro indication MDD, GA
Prozac indication MDD, OCD, PMS, Buli-Nervosa
Sarafem indication PMS
Prozac weely MDD
Paxil, Paxil CR MDD, OCD, PD, SAD, PTSD
Zoloft indication MDD, OCD, PD, PTSD
PTSD and PD Paxil + Zoloft
SAD Paxil, Paxil XR
SSRI dose range Lexapro(10-20), Celexa(10-60), Paroxetine&fluoxetine(10-80), Zoloft (50-200)
Only SSRI have solution Lexapro soln 5mg/5ml.
SNRI Effexor(venlafaxine), Cymbalta(duloxetine), Pristiq(desvenlafaxine), Savella(milnacipran)
DN-agonist Bupropion, not related to 5HT -> not Sex dysfxn.
SRI + alpha blocker trazodone (Desyrel), Nefrazodone (Serzone)
Ghost tablets Venlafaxine ER, Procardia XL, Covera HS
For diabetic peripheral neuropathy (fibromyalgia) Duloxetine (Cymbalta)
Duloxetine dose initial: 30, usual: 60, max 120 (no benefit over 60)
Savella indication fibromyalgia only.
3 dugs approved for fibromyalgia Lyrica(pregabalin), Cymbalta(duloxetine), Savella(milnacipran)
anti-depression & want to incre weight Remeron(mirtazapine)- increase appetite
Created by: thuytaimi
 

 



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