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SSRI
Question | Answer |
---|---|
Celexa | Citolopram |
Lexapro | Escitalopram |
Prozac, Prozac weekly, Sarafem | Fluoxetine |
Luvox | fluvoxetine, for OCD only |
Paxil | Paroxetine |
Zoloft | Sertraline |
5HT1, 5HT2, 5HT3 effects | 5HT1: depression, 5HT2-sexual dysfxn, 5HT3-GI SEs. |
SSRI and Bleeding | 5HT required for Plt aggregation, SSRI incre GI bleeding similar to NSAID, used together incre risk of GI bleeding. Luvox and celexa less bleeding |
SSRI SEs | Activating(fluoxetine)or sedating(fluvoxetine), GI, Sex dysfxn, HA, Hypo-Na, Anticholinergic (Paroxetine only) |
Long t1/2 SSRI | Fluoxetine, d/c MAOI 2 weeks prior to fluoxetine, d/c fluoxetine 5 weeks prior to MAOI. |
Sarafem dose | fluoxetine, start 14 days b4 mens, initial 20mg/d; max 80mg/d |
Prozac Weekly strength | 90mg ER cap, equal to 20mg QD, dose = 1 cap QW start 7 days after last daily dose of fluoxetine. |
Prozac weely indication | MDD only |
fluoxetine indication | MDD, OCD, PMS. Sarafem-PMS, Prozac weekly-MDD |
Paroxtine strength | Paxil: 10,20,30,40mg. Paxil CR: 12.5, 25, 37.5mg |
SSRI used for Bulimia nervosa | Fluoxetine |
Celexa indication | MDD |
Lexapro indication | MDD, GA |
Prozac indication | MDD, OCD, PMS, Buli-Nervosa |
Sarafem indication | PMS |
Prozac weely | MDD |
Paxil, Paxil CR | MDD, OCD, PD, SAD, PTSD |
Zoloft indication | MDD, OCD, PD, PTSD |
PTSD and PD | Paxil + Zoloft |
SAD | Paxil, Paxil XR |
SSRI dose range | Lexapro(10-20), Celexa(10-60), Paroxetine&fluoxetine(10-80), Zoloft (50-200) |
Only SSRI have solution | Lexapro soln 5mg/5ml. |
SNRI | Effexor(venlafaxine), Cymbalta(duloxetine), Pristiq(desvenlafaxine), Savella(milnacipran) |
DN-agonist | Bupropion, not related to 5HT -> not Sex dysfxn. |
SRI + alpha blocker | trazodone (Desyrel), Nefrazodone (Serzone) |
Ghost tablets | Venlafaxine ER, Procardia XL, Covera HS |
For diabetic peripheral neuropathy (fibromyalgia) | Duloxetine (Cymbalta) |
Duloxetine dose | initial: 30, usual: 60, max 120 (no benefit over 60) |
Savella indication | fibromyalgia only. |
3 dugs approved for fibromyalgia | Lyrica(pregabalin), Cymbalta(duloxetine), Savella(milnacipran) |
anti-depression & want to incre weight | Remeron(mirtazapine)- increase appetite |