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Anti-Coagulant

QuestionAnswer
Alteplase Activase, tPA
Alteplase dose AMI: 100mg over 1.5 hrs, PE: 100mg over 2 hrs, Stroke: 0.9mg/kg
Thrombolytic & ASA donot use ASA w/in 24 hrs with ALtalase
Time cut of after reconstitution of thrombolytics Retaplase (4h), Alteplase + streptokinase = (8h)
Retaplase(r-PA) dose AMI: 10 UNITS IV over 2 min, 2nd dose after 30'
Retaplase must be recontituted with Sterile Water
Antigenic thrombolytic Strptokinase
Do not shake vial (thrombolytic) Streptokinase
Streptokinase dose AMI: 1.5 MU IV/60' PE: 3 MU IV/24h
Avoid all ASA product when on Heparin\ Except in STEMI and Unstable angina bleeding
Heparine Vd 60ml/kg
Px & Tx of HIT DTI
DTI elimination Agatroban (liver), Renal = Lepirudin & Bivalrudin. "rudin" = renal
Novastin Agatroban
Refluden Lepirudin
Angiomax Bivalrudin
LMWH pork allergy Dalteparin, Enoxaparin, Ardeparin (DEA)
LMWH sulfite allergy Ardeparin
Protamine/ENOX ratio 1mg/1mg
Protamine/HEP 1mg/100 u heparin. 10-20 mg of Protamine sulfate IV (over at least 5 min)
Protamine/Dalte&Arde 1mg/100u anti-Xa unites
Time onset of VitK factor II-40hrs, X-60hrs
Vit. K dependent factors 2,9,7,10 = tonight go to 7 at 10
Warfarin should not be taken with ASA and NSAIDs Yes
GP2B/3A inhibitor "ATE-RAI"
ADP receptor antagonist Clopidogrel (Plavix), Ticlodipine (Ticlid), Prasugrel (Effient), Cilostazole (Pletal)
Ticlid 250mg BID w/ FOOD
Ticlid Neutropenia: fever, chill, sore throat
Ticlid monitor tiCLid : CBC & Liver
ASA MOA inhibit PG that produce inflammation and interfere w/ synthesis of TXA2
ASA preg cat D
ASA a/s/w Reyes Syndrom Do not give children
Persantine dipyridamole/ inhibit Plt aggregation/ preg. B
Aggrenox ASA + dipyridamole/ 1 cap BID
Persantine dose dipyridamole 75-100mg QID
Dipyridamole other indication for cardiac exercise testing for people who canot walk on treadmill.
Created by: thuytaimi
 

 



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