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Patho Ch 10

TermDefinition
achlorhydria lack of hydrochloric acid in gastric secretions
agglutination clumping together of cells or particles
autoregulation automatic regulation or reflex control of blood flow in an area depending on local needs
bilirubin a product of the break down of hemoglobin, excreted in the bile
cyanotic bluish color of the skin or mucosa that occurs when a large portion of the hemoglobin is unoxxygenated
demyelination loss of the myelin sheath from the nerve surface, interfering with conduction
deoxyhemoglobin hemoglobin not combined with oxygen, formed when oxyhemoglobin releases its oxygen to the tissues
diapedesis passage of leukocytes through intact capillary walls to a site of inflammation
dyscrasia abnormality of the blood or bone marrow; abnormal cell characteristics or numbers
dyspnea difficulty in breathing
ecchymoses reddish blue discoloration of the skin or mucosa because of bleeding
erythrocytosis increase in the total red blood cell mass
erythropoetin a glycoprotein hormone secreted by the kidney in the adult and by the liver in the fetus, which acts on stem cells of the bone marrow to stimulate red blood cell production
ferritin storage form of iron
gastrectomy surgical removal of all or part of the stomach
glossitis inflammation of the tongue
hemarthrosis bleeding into a joint cavity
hematocrit percentage of erythrocytes in a blood sample
hematopoesis The growth and maturation of the blood cells and other formed blood elements in the bone marrow
hemolysis destruction of erythrocytes with release of hemoglobin
hemoptysis frothy sputum containing streaks of blood, spitting up blood
hemosiderin a pigment that is a product of hemolysis; it is an insoluble form of storage iron that is visible microscopically both with and without the use of special stains
hemostasis blood clotting or controlling bleeding
hepatomegaly enlarged liver
hypochromic ale staining red blood cells with broadened central zone of pallor; most often associated with hypochromic, microcytic anemia, thalassemia, and anemia of chronic inflammation
interleukin protein (cytokine) primarily produced byT cells, active in the inflammatory and immune responses and leukocyte communication
leukocytosis an above normal level of leukocytes (WBC's) in the blood
leukopenia a decreased number of leukocytes in the blood
leukopoesis production of leukocytes
macrocytes an abnormally large erythrocyte
macrophages White blood cells whose job is to destroy invading microorganisms
malabsorption impaired absorption of nutrients from the intestines
megaloblasts abnormally large, nucleated, immature erythrocytes
microcytic smaller-than-normal cell
morphology physical size, form, structure and shape of cells or organs
myelotoxins toxin that destroys marrow cells
myelodysplastic A disorder within the bone marrow, characterized by the proliferation of abnormal stem cells, which have the potential of developing into a specific type of leukemia
neutropenia a deficit of neutrophils in the blood
oxyhemoglobin hemoglobin combined with molecular oxygen, the form in which oxygen is transported in the blood
pallor paleness; as of the skin
pancytopenia decrease in all blood cells, erythrocytes, leukocytes and thrombocytes
petechiae tiny, pinpoint hemorrhages under the skin
phlebotomy incision into a vein and collection of blood
plasma the liquid portion of blood after cells are removed
plethoric characterized by an overabundance of blood
reticulocyte An early, immature form of a red blood cell. Over time, the reticulocyte develops to become a mature, oxygen-carrying red blood cell.
serum the liquid portion of blood lacking cells and clotting factors
splenomegaly enlarged spleen
stomatitits inflammation and ulceration in the mouth
syncope fainting; temporary loss of consciousness
tachycardia excessively rapid heartbeat
thrombocytopenia abnormally low number of thrombocytes or platelets
ataxia impaired coordination, imbalance, staggering gait
iron deficiency anemia reduced availability of iron that impairs synthesis of hemaglobin
megalobalstic (pernicious) anemia type of anemia characterized by very large, immature, nucleated erythrocytes
aplastic anemia type of anemia resulting from impairment of bone marrow
sickle cell anemia inherited disorder that creates abnormal hemoglobin S
thalassemia genetic defect in one or more genes controlling structure and amount of hemoglobin produced
hemophilia A blood clotting disorder due to a deficit or abnormality of clotting factor 8
von willebrand blood clotting disorder caused by a deficit of von willebrand factor that helps platelets stick to damaged blood vessels
disseminated intervascular coagulation disorder condition involving excess bleeding and clotting that uses up available clotting factors
myelodysplastic syndrome disease involving inadequate production of cells by the bone marrow
polycythemia vera increased production of erythrocytes and other cells in the bone marrow
leukemia group of neoplastic disorders involving white blood cells
anemia decrease in hemoglobin content that reduces oxygen transport in the blood
iron deficiency anemia caused by insufficient intake, chronic loss from bleeding, malabsorption, liver disease, some infections or cancers
Megaloblastic (pernicious) anemia caused by autoimmune chronic gastritis, or gastrectomy which causes insufficient intrinsic factor
aplastic anemia caused by idiopathic, myelotoxins, viral infections such as Hep C, autoimmune disorders such as Lupus or genetic
sickle cell anemia caused by an autosomal recessive disorder
thalassemia caused by an autosomal dominant genetic disorder
Hemophilia A caused by an x linked recessive genetic disorder
Von Wilderband caused by a hereditary clotting disorder
Disseminated Intravascular Coagulation disorder caused by excessive bleeding and excessive clotting (trauma or obstetrical complications) that use up clotting factors
myelodysplastic syndrome cause can be idiopathic or due to chemotherapy or radiation treaments
polycythemia vera caused by a neoplastic disorder or can be a compensation for low oxygen levels
leukemia caused by a neoplastic disorder affecting white blood cells
anemia can be caused by decreased iron intake, malabsorption, blood loss, decreased intrinsic factor, bone marrow or gentic causes
Iron deficiency Symptoms include pallor, fatigue, irritability, brittle hair, stomatitus, glossitus, tachyacardia and palpitations
Pernicious anemia Symptoms include basic manifestations of anemia, enlarged to own tongue, nausea, diarrhea and paresthesias
Aplastic anemia Symptoms include an insidious onset of anemia, leukopenia, and thrombocytopenia
Sickle cell anemia Symptoms do not appear until approximately 12 months old with severe anemia, hyperbillirubinemia and jaundice, Splenomegaly, pain and organ damaged related to occlusions
Thalassemia Symptoms include signs of anemia, hypoxia, impaired growth and development, And the development of heart failure
Hemophilia A Symptoms include prolonged hemorrhage following minor trauma, blood in the urine or feces
Von willebrand Symptoms include skin rashes, nosebleeds, easy bruising, bleeding of the gums and abnormal menstrual bleeding
disseminated intervascular coagulation disorder Symptoms include increased bleeding and clotting resulting in a loss of clotting factors
Myelodysplastic syndrome Symptoms include anemia's and Pancytopenia
Polycythemia Vera Symptoms include cyanosis, hypnomegaly, spleenomegally, increased blood pressure, bounding pulse, Dyspnea headaches, visual disturbances and congestive heart failure
Leukemia Symptoms include infections, hemorrages, anemia, weight loss, bone pain and fatigue
Created by: boringjen
 

 



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