click below
click below
Normal Size Small Size show me how
Patho Ch 10
| Term | Definition |
|---|---|
| achlorhydria | lack of hydrochloric acid in gastric secretions |
| agglutination | clumping together of cells or particles |
| autoregulation | automatic regulation or reflex control of blood flow in an area depending on local needs |
| bilirubin | a product of the break down of hemoglobin, excreted in the bile |
| cyanotic | bluish color of the skin or mucosa that occurs when a large portion of the hemoglobin is unoxxygenated |
| demyelination | loss of the myelin sheath from the nerve surface, interfering with conduction |
| deoxyhemoglobin | hemoglobin not combined with oxygen, formed when oxyhemoglobin releases its oxygen to the tissues |
| diapedesis | passage of leukocytes through intact capillary walls to a site of inflammation |
| dyscrasia | abnormality of the blood or bone marrow; abnormal cell characteristics or numbers |
| dyspnea | difficulty in breathing |
| ecchymoses | reddish blue discoloration of the skin or mucosa because of bleeding |
| erythrocytosis | increase in the total red blood cell mass |
| erythropoetin | a glycoprotein hormone secreted by the kidney in the adult and by the liver in the fetus, which acts on stem cells of the bone marrow to stimulate red blood cell production |
| ferritin | storage form of iron |
| gastrectomy | surgical removal of all or part of the stomach |
| glossitis | inflammation of the tongue |
| hemarthrosis | bleeding into a joint cavity |
| hematocrit | percentage of erythrocytes in a blood sample |
| hematopoesis | The growth and maturation of the blood cells and other formed blood elements in the bone marrow |
| hemolysis | destruction of erythrocytes with release of hemoglobin |
| hemoptysis | frothy sputum containing streaks of blood, spitting up blood |
| hemosiderin | a pigment that is a product of hemolysis; it is an insoluble form of storage iron that is visible microscopically both with and without the use of special stains |
| hemostasis | blood clotting or controlling bleeding |
| hepatomegaly | enlarged liver |
| hypochromic | ale staining red blood cells with broadened central zone of pallor; most often associated with hypochromic, microcytic anemia, thalassemia, and anemia of chronic inflammation |
| interleukin | protein (cytokine) primarily produced byT cells, active in the inflammatory and immune responses and leukocyte communication |
| leukocytosis | an above normal level of leukocytes (WBC's) in the blood |
| leukopenia | a decreased number of leukocytes in the blood |
| leukopoesis | production of leukocytes |
| macrocytes | an abnormally large erythrocyte |
| macrophages | White blood cells whose job is to destroy invading microorganisms |
| malabsorption | impaired absorption of nutrients from the intestines |
| megaloblasts | abnormally large, nucleated, immature erythrocytes |
| microcytic | smaller-than-normal cell |
| morphology | physical size, form, structure and shape of cells or organs |
| myelotoxins | toxin that destroys marrow cells |
| myelodysplastic | A disorder within the bone marrow, characterized by the proliferation of abnormal stem cells, which have the potential of developing into a specific type of leukemia |
| neutropenia | a deficit of neutrophils in the blood |
| oxyhemoglobin | hemoglobin combined with molecular oxygen, the form in which oxygen is transported in the blood |
| pallor | paleness; as of the skin |
| pancytopenia | decrease in all blood cells, erythrocytes, leukocytes and thrombocytes |
| petechiae | tiny, pinpoint hemorrhages under the skin |
| phlebotomy | incision into a vein and collection of blood |
| plasma | the liquid portion of blood after cells are removed |
| plethoric | characterized by an overabundance of blood |
| reticulocyte | An early, immature form of a red blood cell. Over time, the reticulocyte develops to become a mature, oxygen-carrying red blood cell. |
| serum | the liquid portion of blood lacking cells and clotting factors |
| splenomegaly | enlarged spleen |
| stomatitits | inflammation and ulceration in the mouth |
| syncope | fainting; temporary loss of consciousness |
| tachycardia | excessively rapid heartbeat |
| thrombocytopenia | abnormally low number of thrombocytes or platelets |
| ataxia | impaired coordination, imbalance, staggering gait |
| iron deficiency anemia | reduced availability of iron that impairs synthesis of hemaglobin |
| megalobalstic (pernicious) anemia | type of anemia characterized by very large, immature, nucleated erythrocytes |
| aplastic anemia | type of anemia resulting from impairment of bone marrow |
| sickle cell anemia | inherited disorder that creates abnormal hemoglobin S |
| thalassemia | genetic defect in one or more genes controlling structure and amount of hemoglobin produced |
| hemophilia A | blood clotting disorder due to a deficit or abnormality of clotting factor 8 |
| von willebrand | blood clotting disorder caused by a deficit of von willebrand factor that helps platelets stick to damaged blood vessels |
| disseminated intervascular coagulation disorder | condition involving excess bleeding and clotting that uses up available clotting factors |
| myelodysplastic syndrome | disease involving inadequate production of cells by the bone marrow |
| polycythemia vera | increased production of erythrocytes and other cells in the bone marrow |
| leukemia | group of neoplastic disorders involving white blood cells |
| anemia | decrease in hemoglobin content that reduces oxygen transport in the blood |
| iron deficiency anemia | caused by insufficient intake, chronic loss from bleeding, malabsorption, liver disease, some infections or cancers |
| Megaloblastic (pernicious) anemia | caused by autoimmune chronic gastritis, or gastrectomy which causes insufficient intrinsic factor |
| aplastic anemia | caused by idiopathic, myelotoxins, viral infections such as Hep C, autoimmune disorders such as Lupus or genetic |
| sickle cell anemia | caused by an autosomal recessive disorder |
| thalassemia | caused by an autosomal dominant genetic disorder |
| Hemophilia A | caused by an x linked recessive genetic disorder |
| Von Wilderband | caused by a hereditary clotting disorder |
| Disseminated Intravascular Coagulation disorder | caused by excessive bleeding and excessive clotting (trauma or obstetrical complications) that use up clotting factors |
| myelodysplastic syndrome | cause can be idiopathic or due to chemotherapy or radiation treaments |
| polycythemia vera | caused by a neoplastic disorder or can be a compensation for low oxygen levels |
| leukemia | caused by a neoplastic disorder affecting white blood cells |
| anemia | can be caused by decreased iron intake, malabsorption, blood loss, decreased intrinsic factor, bone marrow or gentic causes |
| Iron deficiency | Symptoms include pallor, fatigue, irritability, brittle hair, stomatitus, glossitus, tachyacardia and palpitations |
| Pernicious anemia | Symptoms include basic manifestations of anemia, enlarged to own tongue, nausea, diarrhea and paresthesias |
| Aplastic anemia | Symptoms include an insidious onset of anemia, leukopenia, and thrombocytopenia |
| Sickle cell anemia | Symptoms do not appear until approximately 12 months old with severe anemia, hyperbillirubinemia and jaundice, Splenomegaly, pain and organ damaged related to occlusions |
| Thalassemia | Symptoms include signs of anemia, hypoxia, impaired growth and development, And the development of heart failure |
| Hemophilia A | Symptoms include prolonged hemorrhage following minor trauma, blood in the urine or feces |
| Von willebrand | Symptoms include skin rashes, nosebleeds, easy bruising, bleeding of the gums and abnormal menstrual bleeding |
| disseminated intervascular coagulation disorder | Symptoms include increased bleeding and clotting resulting in a loss of clotting factors |
| Myelodysplastic syndrome | Symptoms include anemia's and Pancytopenia |
| Polycythemia Vera | Symptoms include cyanosis, hypnomegaly, spleenomegally, increased blood pressure, bounding pulse, Dyspnea headaches, visual disturbances and congestive heart failure |
| Leukemia | Symptoms include infections, hemorrages, anemia, weight loss, bone pain and fatigue |