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Biochemistry

Krebs Cycle

QuestionAnswer
What is the Krebs cycle also known as? Citric acid cycle, Tricarboxylic acid cycle (TCA))
Where in the cell does the Krebs cycle take place? Mitochondrial matrix
What are the regulatory enzymes of the Krebs cycle? Citrate synthase, Isocitrate dehydrogenase, Alpha-ketoglutarate dehydrogenase
How many steps are there in the Krebs cycle? 8 (not including the production of cis-aconitate)
How many ATP are produced per turn of TCA cycle? 12 ATP
How many ATP are produced in the Kreb Cycle per glucose molecule? 24 ATP
How many NADH molecules are produced per turn of TCA cycle? 3
How many FADH2 molecules are produced per turn of TCA cycle? 1
How many GTP molecules are produced per turn of TCA cycle? 1
How many ATP are produced from the 3 NADH in the Krebs cycle? 9 ATP (via ETC)
How many ATP are produced from the 1 FADH2 in the Krebs cycle? 2 ATP (via ETC)
How many ATP are produced from the 1 GTP in the Krebs cycle? 1 ATP (substrate level phosphorylation)
What are all the steps of the Krebs cycle? Oxaloacetate to Citrate to Cis-aconitate to Isocitrate, to Alpha-ketoglutarate, Succinyl CoA to Succinate to Fumarate to Malate back to Oxaloacetate
Krebs cycle pneumonic Our Cousin Ciselia Is Kissing Sixty Six French Men
Acetyl CoA is a how many carbon compound? 2
What does acetyl-CoA combine with when entering the Krebs cycle? Oxaloacetate
Oxaloacetate is a how many carbon compound? 4
In Krebs cycle, when oxaloacetate binds with acetyl-coA, what is formed? Citrate
Citrate is a how many carbon compound? 6
What enzyme is used to go from oxaloacetate and acetyl-CoA to citrate? Citrate synthase
In the Krebs cycle, what does citrate turn into? Cis-aconitate (sometimes viewed as next step) or Isocitrate (more commonly viewed as next step)
Cis-aconitate is a how may carbon compound? 6
In the Krebs cycle, what does aconitase turn into? Isocitrate
What enzyme is used to go from citrate to aconitase to isocitrate? Aconitase
Isocitrate is a how many carbon compound? 6
In the Krebs cycle, what does isocitrate turn into? Alpha-ketoglutarate
What enzyme is used to go from isocitrate to alpha-ketoglutarate? Isocitrate dehydrogenase
Alpha-keto glutarate is a how many carbon compound? 5
In the Krebs cycle, what does alpha-ketoglutarate turn into? Succinyl-CoA
What enzyme is used to go from alpha-ketoglutarate to succinyl-coA? Alpha-ketoglutarate dehydrogenase
Succinyl-CoA is a how many carbon compound? 4
In the Krebs cycle, what does succinyl-CoA turn into? Succinate
What enzyme is used to go from succinyl-CoA to succinate? Succinate Thiokinase
Succinate is a how many carbon compound? 4
In the Krebs cycle, what does succinate turn into? Fumarate
What enzyme is used to go from succinate to fumarate? Succinate Dehydrogenase
Fumarate is a how many carbon compound? 4
In the Krebs cycle, what does fumarate turn into? Malate
What enzyme is used to go from fumarate to malate? Fumarase
Malate is a how many carbon compound? 4
In the Krebs cycle, what does malate go to? Oxaloacetate
What enzyme is used to go from malate to oxaloacetate? Malate Dehydrogenase
What steps in the Krebs cycle produce the reduced coenzyme, NADH + H+? Isocitrate to Alpha-ketoglutarate, Alpha-ketoglutarate to Succinyl-CoA, Malate to Oxaloacetate
What steps in the Krebs cycle produce the reduced coenzyme, FADH2? Succinate to Fumarate
What steps in the Krebs cycle is there a substrate level phosphorylation? Succinyl-Coa to Succinate (GTP is produced)
What steps in the Krebs cycle is there a decarboxylation taking place? Isocitrate to Alpha-ketoglutarate, Alpha-ketoglutarate to Succinyl-CoA
Created by: NWHSU
 

 



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