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Anesthesia

QuestionAnswer
Abnormalities in Malignant hyperthermia AD abnormality in Type 1 ryanodine receptor. Imcreased ca2+ in Sarcoplasma. Prolonged sustained contraction
Rate of rise of temp in malignant hyperthermia 1 deg C / 5 min
Mortality in malignant hyperthermia 4%
Risk of malignant hyperthermia in patient who develpp masseter contraction on SCh >50%
Most sensitive and earliest sign of malignant hyperthermia Rising EtCO2
MC distinguishing feature between thyrotoxicosis and malignant hyperthermia Thyrotoxicosis - HYPOKALEMIA Malig hyper - HYPERKALEMIA
Mcc death in malignant hyperthermia HYPERKALEMIA
Dose of dantrolene in Malignant hyperthermia It blocks ryanodine receptor 2mg/kg iv every 5 min Max of 10 mg/kg Followed by 1mg/kg iv 6 hourly for next 24 hrs.
Effect on MaC in pregnancy MAC decreases by 8-12 wks. Pog It is due to progesterone
Weaning ventilation modes All modes other than IPPV and CMV
MC used weaning ventilation SIMV Synchronized intermittent mandatory ventilation
Which mode of ventilation is used initially in any condition CMV - controlled mechanical ventilation IPPV
In case of intrarterial inj of Thiopentone what procedure to do Do a stellate ganglion block
Stellate ganglion is formed by Fusion of UPPER THORACIC AND CERVICAL GANGLION
Landmark for stellate ganglion Chsgnaic tubercle
Identification for epidural space Loss of resistance and hanging 💧
Drug used in spinal anesthesia Lignocaine 5% Bupivacaine 0.5%
Mc and early complication of soinal Hypotension
Vasopressor of choice in hypptension due to spinal Ephedrine
Cranial nerve involvement in rare in spinal anesthesia. Which is involved? CN6
Headache of spinal anesthesia characteristics Msinly occioital After 24 of sx Sevre if pt stands within 24 hrs. Stays for 3-7 days Never beyond 3-4 wks
Symlathetic suppy of heart from whcih vertebrae level T2,3,4
inhalational agent which undergoes max metabolism Halothane
Haltohane is metabolised by 20% in liver
mortality in halothane heptatitis 1 in 10 k. DUE TO HEPATOTOXIC ENDPRODUCTS
DOC for halothane shakes Pethidine - Halothane causes Shivering in post op period aka - halothane shake
Inhalational agent of choice in neuro sx Isoflurane -- Min increase in ICT
desflurane is strucural analogue of Isoflurane
Halothane is store in Amber bottles, with thymol 0.01% as preservative
Inhalational agen with fastest onset Xenon - BG - o.14 ; desflurane- 0.42 B/gcoeff
inhaltaional agent which is indicated in a patient with shock Desflurane, Causes minimal myocardial depression and increades hR and BP
non nephrotoxic inhalational agents Halothane, desflurane and Isoflurane
who discovere N2O Priestly
Gave the term laughing gas Humphrey Davy
combination of EtNOX 50% N2O and 50% O2
fink phenomena is aka Diffusion hypoxia. Seen at reversal of N2O anesthesia.
Second gas effect If N2O given with other inhalational agent then there is increase in Aveolar concentration of N2O-----> faster induction
complete anesthetic agent Ether - causes Anesthesia, analgesia and muscle relaxant. ALso is the SAFEST AGENT. NO CARDIAC OR RESP DEPRESSION
solubility of N2O vs N2 35 times more than N2
stage of surgical anesthesia Stage 3 , Plane 2
Stage best for intubation stage 3 , plane 3 --- the laryngeal reflex are lost at this stage
Corneal reflex are lost at Stage 3, plane 2
eyelash reflex is lost at stage 2
skin, conjunctiva and pharyngeal reflex are lost at stage 3, plane1
carinal reflex is lost at Stage 3 plane 4
abolition of brain stem relfexes is lost at Stage 4. there is medullary paralysis and pupils are fully dilated.
Created by: manish01
 

 



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