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Anesthesia
| Question | Answer |
|---|---|
| Abnormalities in Malignant hyperthermia | AD abnormality in Type 1 ryanodine receptor. Imcreased ca2+ in Sarcoplasma. Prolonged sustained contraction |
| Rate of rise of temp in malignant hyperthermia | 1 deg C / 5 min |
| Mortality in malignant hyperthermia | 4% |
| Risk of malignant hyperthermia in patient who develpp masseter contraction on SCh | >50% |
| Most sensitive and earliest sign of malignant hyperthermia | Rising EtCO2 |
| MC distinguishing feature between thyrotoxicosis and malignant hyperthermia | Thyrotoxicosis - HYPOKALEMIA Malig hyper - HYPERKALEMIA |
| Mcc death in malignant hyperthermia | HYPERKALEMIA |
| Dose of dantrolene in Malignant hyperthermia | It blocks ryanodine receptor 2mg/kg iv every 5 min Max of 10 mg/kg Followed by 1mg/kg iv 6 hourly for next 24 hrs. |
| Effect on MaC in pregnancy | MAC decreases by 8-12 wks. Pog It is due to progesterone |
| Weaning ventilation modes | All modes other than IPPV and CMV |
| MC used weaning ventilation | SIMV Synchronized intermittent mandatory ventilation |
| Which mode of ventilation is used initially in any condition | CMV - controlled mechanical ventilation IPPV |
| In case of intrarterial inj of Thiopentone what procedure to do | Do a stellate ganglion block |
| Stellate ganglion is formed by | Fusion of UPPER THORACIC AND CERVICAL GANGLION |
| Landmark for stellate ganglion | Chsgnaic tubercle |
| Identification for epidural space | Loss of resistance and hanging ð§ |
| Drug used in spinal anesthesia | Lignocaine 5% Bupivacaine 0.5% |
| Mc and early complication of soinal | Hypotension |
| Vasopressor of choice in hypptension due to spinal | Ephedrine |
| Cranial nerve involvement in rare in spinal anesthesia. Which is involved? | CN6 |
| Headache of spinal anesthesia characteristics | Msinly occioital After 24 of sx Sevre if pt stands within 24 hrs. Stays for 3-7 days Never beyond 3-4 wks |
| Symlathetic suppy of heart from whcih vertebrae level | T2,3,4 |
| inhalational agent which undergoes max metabolism | Halothane |
| Haltohane is metabolised by | 20% in liver |
| mortality in halothane heptatitis | 1 in 10 k. DUE TO HEPATOTOXIC ENDPRODUCTS |
| DOC for halothane shakes | Pethidine - Halothane causes Shivering in post op period aka - halothane shake |
| Inhalational agent of choice in neuro sx | Isoflurane -- Min increase in ICT |
| desflurane is strucural analogue of | Isoflurane |
| Halothane is store in | Amber bottles, with thymol 0.01% as preservative |
| Inhalational agen with fastest onset | Xenon - BG - o.14 ; desflurane- 0.42 B/gcoeff |
| inhaltaional agent which is indicated in a patient with shock | Desflurane, Causes minimal myocardial depression and increades hR and BP |
| non nephrotoxic inhalational agents | Halothane, desflurane and Isoflurane |
| who discovere N2O | Priestly |
| Gave the term laughing gas | Humphrey Davy |
| combination of EtNOX | 50% N2O and 50% O2 |
| fink phenomena is aka | Diffusion hypoxia. Seen at reversal of N2O anesthesia. |
| Second gas effect | If N2O given with other inhalational agent then there is increase in Aveolar concentration of N2O-----> faster induction |
| complete anesthetic agent | Ether - causes Anesthesia, analgesia and muscle relaxant. ALso is the SAFEST AGENT. NO CARDIAC OR RESP DEPRESSION |
| solubility of N2O vs N2 | 35 times more than N2 |
| stage of surgical anesthesia | Stage 3 , Plane 2 |
| Stage best for intubation | stage 3 , plane 3 --- the laryngeal reflex are lost at this stage |
| Corneal reflex are lost at | Stage 3, plane 2 |
| eyelash reflex is lost at | stage 2 |
| skin, conjunctiva and pharyngeal reflex are lost at | stage 3, plane1 |
| carinal reflex is lost at | Stage 3 plane 4 |
| abolition of brain stem relfexes is lost at | Stage 4. there is medullary paralysis and pupils are fully dilated. |