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Mielo

clasificacion y marcadores

QuestionAnswer
M0 (mieloblastica muy diferenciada) CD11, CD13, CD33, CD34, 117
M1 (mieloblastica con poca diferenciacion) CD11, CD13,CD34, 117 Cuerpos de Auer MIELOPEROXIDASA POSITIVA SUDAN negro POSITIVA
M2 (mieloblastica con diferenciacion) CD11, CD13, CD33, CD34, CD15, 117 Cuerpos de Auer MIELOPEROXIDASA POSITIVA SUDAN negro POSITIVA T(8:21)
M3 promieloblastica CD11, CD13, CD33, CD34, CD15, HLADR Cuerpos de Auer +++++ MIELOPEROXIDASA POSITIVA SUDAN negro POSITIVA T(15:17)
M4 mielomonoblastica CD13, CD33, CD15, CD14, CD11b ESTERASA POSITIVO “Cortejo” Cuerpos de Auer MIELOPEROXIDASA POSITIVA MUY INVASIVAS: infiltran piel y encías Con eosinofilia Inversion del cromosoma 16
M5 monoblastica CD13, CD33, CD15, CD14, CD11b Gran tendencia a infiltrar encías, es común en niños y ancianos y puede infiltrar SNC Coagulacion intravascular Diseminada (CID) MUY INVASIVAS: infiltran piel y encías Esterasa positivo
M6 eritroleucemia Subaguda Glicoforina! Tinción PAS positivo ( Ácido Peryódico Reactivo de Schiff)
M7 megacarioblastica CD34, CD41, CD42, CD62, Factor Von Willebrand Requiere de citofluorometria para su dx Tinción PAS positivo ( Ácido Peryódico Reactivo de Schiff) Fibrosis de MO
Created by: studymachine
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