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ClinChem2 Last test

Practice test for ClinChem2, tumor markers, toxicology, drug monitoring.

What represents the 4 principal biological events governing drug dispersion? 1. Absorption 2. Distribution 3. Biotransformation 4. excretion
What analyte would be useful to measure in a patient taking a nephrotoxic drug? creatinine
First-pass effect occurs in which organ of the body? Liver
The major enzyme system that metabolizes a drug in phase a I-type reaction is ? Apolipoprotein P450
A drug agonist is described as ? a drug that binds to receptors and mimics the regulatory effects of the endogenous signalling compounds.
When should a trough level for drug measurement be found? Just before the next dose
When the concentration of a drug, like digoxin, is measured by the most routinely used immunoassay, what is actually measured? Total drug concentration
Toxic levels of methotrexate may result in what? Bone disease/marrow abnormalities
Ethylene glycol metabolizes to what acid? Oxalic acid
What class of compounds may be included in drugs-of-abuse screening (DAU)? Barbituates
What is an example of a definitive or reference method that is suitable for confirming positive drugs-of-abuse testing (DAU)? GCMS
Toxic doses of acetominophen can cause serious damage to what organ in the body? Liver
Carbon monoxide affinity for hemoglobin is ? 200-250 times greater than oxygen's affinity for hemoglobin.
What statement provides an accurate description of drug screening methods? They provide qualitative information on a particular class of drugs.
Reyes syndrome is associated with what substance? Salicylate/aspirin
What blood group antigen is CA 19-9 derived from? Le-a
Alpha-fetoprotein is useful in detecting which carcinoma? hepatocellular
The biochemical marker CA 125 is expressed by what tissue? epithelial cells of the ovaries
Biomarkers designed with the prefix letters CA contain a significant amount of what compound? Carbohydrate
Diagnostic sensitivity represents what condition? Positively (or positivity?) in disease
Measuring serum levels of CA 15-3 is clinically useful for what reason? Monitoring the clinical course of patients with metastatic breast cancer.
Alpha-fetoprotein is a marker for what cancer? hepatocellular carcinoma
Cancer-antigen 125 (CA-125) is a marker for what cancer? ovarian
Carbohydrate Antigen 15-3 (CA 15-3) is a marker for what cancer? breast
Human epididymisprotein (HE4) is a specific marker for what cancer? ovarian
BRCA1 and BRCA2 are gene mutations associated with what cancer? breast
Carcinoembryonic Antigen (CEA) is a marker for what cancer? colorectal (also lung, breast, and gastrointestinal tumors)
CA 19-9 is a marker for what cancer? pancreatic (LE-a-b- people do not express this marker)
Human chorionic gonadotropin (HCG) is a marker for what cancer? trophoblastic tumors (but not FDA approved)
Prostate-specific antigen (PSA) is a marker for what cancer? prostate (also BPH and prostatitis)
PCA-3 is a specific marker for what cancer? prostate (it stands for prostate cancer gene 3)
Digoxin is what type of drug? cardiac glycosides
Quinidine, Procainamide, Dispyramide, are all what class of drugs? antiarrythmics
Vancomycin and aminoglycosides are both what type of drugs? antibiotics
Phenobarbital, Phenytoin, Carbamazepine, Ethosuximide, and Valproic acid are all what kind of drugs? antiepileptic drugs
Lithium, tricyclic antidepressants, clozapine, and olanzapine are all what kind of drugs? psychoactive
Cyclosporine, tacrolimus, sirolimus, and Mycophenolic acid are all which kind of drugs? immunosuppressive
Felbamate and Babapentin are both what kind of drugs? 2nd generation antiepileptic drugs
Methotrexate is what class of drugs? antineoplastic
Drug X has a half-life of 15 hours. When will the patient reach a steady state in the therapeutic range? Is it 1 day, 3 days, 5 days, or 7 days? 5 days (since 4 is not an answer)
The factor for figuring out the time needed to achieve a steady state is ? 5-7 : use the factor that matches the choices given on the test : multiply the number of hours by the factor, then divide by 24 to find out how many days.
If a patient has a renal insufficiency, would he reach the steady state sooner or later? Sooner, because the kidneys would not remove the drug in the urine as quickly.
Which is a faster means of drug absorption: IV or inhalation? Both are about the same.
The most common drug of abuse in the US is ? Alcohol
Don't forget to try the "Targets" button below to practice matching up tumor markers. Just click on "targets" below.
I have a medication matching test as well. http://www.studystack.com/flashcards-1578487
Created by: IsaacJ