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The Langerhans Cell

Structure & Function of the Langerhans Cell

QuestionAnswer
Langerhans cells are derived from what cell line? monocyte/macrophage
What is the function of the Langerhans cell? antigen-presenting cell
Where in the epidermis are Langerhans cells found? in all layers- but mostly the stratum spinosum
Langerhans cells are connected to keratinocytes via what protein? e-cadherin
Langerhans cells produce primarily what cytokine? IL-1
Name the Langerhans cell stains? -Langerin -S100 -CD1a -actin -vimentin -ATPase (the first to development) -Fc receptor
How do Langerhans cells stimulate T cells? after encountering an antigen in the skin, it matures and migrates to a lymph node where it presents the antigen to a naive T cell
What common treatment for eczema and psoriasis functionally impairs Langerhans cells? UV radiation
Name of the tennis raquet shape body in the Langerhans cell Birbeck granule
Shape of the nucleus of a Langerhans cell Kidney bean
What are the main features of Hand-Schuller-Christian disease -Diabetes insipidus -exophthalmos -bone lesions
Created by: criddel
 

 



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