Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Hematology 1-4
Hematopoiesis
| Question | Answer |
|---|---|
| process by which the body maintains the balance between hemorrhage and thrombosis. | Hemostasis |
| Thrombosis is same as ______ | clotting |
| a pathological activation of coagulation mechanisms that happens in response to a variety of diseases. It leads to the formation of small blood clots inside the blood vessels and abnormal bleeding occurs when they are disrupted. | DIC (disseminated intravascular coagulation) |
| Process of blood cell production and development. Continuous turnover of RBC, WBC, and PLT populations | hematopoiesis |
| Where hematopoiesis is taken place? | bone marrow, liver, spleen lymph nodes, thymus, yolk sac |
| this is glycoproteins and growth factor which bind to receptor proteins on the surfaces of hematopoietic stem cells and activate intracelluar signaling pathways to cause the cells to proliferate and differentiate into a specific kind of blood cell. | CSF (Colony-stimulating factors) |
| In terms of ontogeny of hematopoiesis, in 1st few weeks of gestational age (embryo), hematopoietic stem cells are derived from __________ stem cells from ________. | mesenchymal, yolk sac |
| At 2 months of gestation, the place of hematopoiesis moves to _______. | liver |
| At 3 to 6 months of gestation, ________ is involved in hematopoiesis. | spleen |
| at 7 months of gestation, __________ are involved in hematopoiesis. | all BM |
| List the place of hematopoiesis from earlier. | yolk sac--> liver-->spleen-->all BM |
| In neonate and childhood, _____ and ______ stop hematopoiesis and marrow volume is equal to adult volume. | liver and spleen |
| AT 18 to 20 years, _______, sternum, ribs, pelvis, spine and skull are the place of hematopoiesis. | long bones |
| At 40+ age, BM to cells ratio becomes _________. | 50:50 |
| As age increases, BM __________. | decreases |
| What are primary lymphoid organs? | thymus, bone marrow |
| what are secondary lymphoid organs? | lymph nodes, spleen |
| this blood component function is cellular and humoral immunity | lymphocytes |
| this blood component function is transport oxygen and carbon dioxide | erythrocytes |
| this blood component function is maintain hemostasis | platelets |
| There are some kinds of hematopoesis pools. This contains multipotential stem cells and unipotential committed stem cells. | stem cell pool |
| there are some kinds of hematopoesis pools. This is consisted with 2 subgroups of pools in bone marrow. | bone marrow pool |
| there are some kinds of hematopoesis pools. this is _________ pool where proliferating and maturation take place. | functional |
| there are some kinds of hematopoesis pools. this is ________ pool where cells are waiting for release to the peripheral blood. | storage |
| ______pool and ______pool are in both peripheral blood and bone marrow. | functional, storage |
| _______% of granulocytes are circulating and _______% are in storage(marginal) pool. | 50, 50 |
| ________% of thrombocytes are circulating and ________% are in storage pool | 70, 30 |
| _______% of erythrocytes are circulating and _______% are in storage pool. | 100,0 |
| what six organs are involved in hematopoiesis? | bone marrow, liver, spleen thymus, lymph nodes, yolk sac |
| hematopoiesis in the yolk sac stops when? | 8 weeks or 2 months |
| what gestational age does the liver take over hematopoiesis? | 8 weeks of 2 months |
| embryonic hemoglobins are produced in what organ? | yolk sac |
| how can the marrow mass of a baby be the same as an adult? | all the marrow are hematopoietically active. little of no adipose are contained in baby's marrow. |
| name the bone in the adult that have hmatopoieticlally active marrow? | sternum, hip, skull, vertebrae, ribs, long bones |
| stem cells are found in what bone marrow pool? | functional pool |
| what cell or cells are in the marginal pool of the peripheral blood? what percentage? | neutrophils, 50% |
| The multipotent stem cells which give rise to several cell lines are called _________. | Colocy-Forming Unit |
| Erythropoiesis occurs in _________ in response to __________. | medullary marrow, Erythropoietin (EPO) |
| What is the multipotent projenitor cells which come first in the Erythropoiesis series? | CFU-GEMM |
| What is the projenitor cells which come after CFU-GEMM? | BFU-E (Burst forming Unit-Erythroid) |
| What is the projenitor cells which come after BFU-E? | CFU-E |
| What factor acts on BFU-E to produce erythrocytes? | EPO (Erythropoietin) |
| How long the nucleated stage of erythropoiesis last? | about 5 days |
| One Erythroblast can form how many mature RBCs? | 14-16 |
| Decreased ___________ causes the kidney to produce erythropoietin. | oxygen tension |
| Hgb synthesis occurs until the RBC loses its ______ and _______ through _____________. | RNA, mitochondoria, reticulocyte stage |
| Through Myelopoiesis, what kinds of cells are made? | neutrophil, eosinophil, basophil |
| How long is maturation and division of the myeloid series in the marrow required? | 7-10 days |
| what kinds of stage(cells) can be seen in proliferative or mitotic pools of myelopoiesis? | stem cells, myeloblasta, promylocytes, myelocytes |
| what kinds of stage(cells) can be seen in maturation pool of myelopoiesis? | metamyelocytes, bands |
| what kinds of stage(cells) can be seen in strage pool of myelopoiesis? | mature cells (segmented) |
| When you see metapyelocytes in Myelopoiesis, what kind of sign is it? | end of DNA synthesis |
| When you start to see indentation of the nucleus in Myelopoiesis, what stage is it? | metamyelocyte |
| In monopoiesis, what cells are precursors? | Monoblasts, Promonocytes |
| List the stages of Lymphopoiesis. | Lymphoblasts -> Prolymphocytes -> Lymphocytes |
| Which cells have problem in APL? | prolymphocytes |
| List the stages of Megalaryocytopoiesis. | proliferation, fragmentation, megakaryocytes, endomitosis, thrombocytes |
| What is endomitosis? | doubling of the nucleus without dividing. |
| CFU-GEMM cells can produce what kinds of cells? | granulocyte, erythrocyte, macrophage/monocyte, megakaryocyte |
| CFU-GM cells can produce what kinds of cells? | granulocyte, macrophage/monocyte |
| In hematopoiesis, which cells are pluripotential? | hematopoitic stem cells |
| in hematopoiesis, which cells are multipotential? | CFU-GEMM |
| In hematopoiesis, which cells are committed progenitor stem cells? | CFU-GM, CFU-Eo, CFU-MEG, BFU-E |
| Pluripotential stem cell gives rise to the ______ stem cells. | multipotential, CFU-GEMM, Lymphoid stem cells |
| Examples of Colony-stimulating factors | growth factors, EPO, G-CSF |
| This is cytokines which stimulates proliferation of specific cells | Colony-stimulating factors |
| This stimulates proliferation and differentiation of specific cell lines and work together with CSFs | Interleukin |
| This is erythropoietic stimulating factor produced in the kidney | erythropoietin |
| this is hormonal factor that controls production and release of platelets | thrombopoietin |
| cell surface antigens on hemopoietic cells | Cluster Designation (CD) |
| By immunophenotyping, if you see 70% CD5 and 90% CD3, what you can see? | T-cell population is dominant |
| By immunophenotyping, if you see CD34, what you can see? | stem cell origin |
| By immunophenotyping, if you see TdT positive, what you can see? | immature cells |
Created by:
hiroko2014