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Pharmacokinetics
Overview for undergrad Medicinal Chem
Question | Answer |
---|---|
Factors to consider in Pharmicokinetics (ADME) | Drug Absorption Drug Distribution Drug Metabolism Drug Excretion |
Orally taken drugs must cross _______. | the gut wall |
Orally taken drugs require balance of _______ character. | hydrophylic / phobic |
Orally active drugs obey _________ _____ __ _______. | Lipinski's Rule of Five |
Polar drugs can be administered by _______. | injection |
List Lipinski's Rule of Five | MW < 500 <,= 5 HBD groups <,= 10 HBA groups logP < +5 |
logP is a measure of _____ _________. | drug's hydrophobicity |