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Overview for undergrad Medicinal Chem

Factors to consider in Pharmicokinetics (ADME) Drug Absorption Drug Distribution Drug Metabolism Drug Excretion
Orally taken drugs must cross _______. the gut wall
Orally taken drugs require balance of _______ character. hydrophylic / phobic
Orally active drugs obey _________ _____ __ _______. Lipinski's Rule of Five
Polar drugs can be administered by _______. injection
List Lipinski's Rule of Five MW < 500 <,= 5 HBD groups <,= 10 HBA groups logP < +5
logP is a measure of _____ _________. drug's hydrophobicity
Created by: kristin_leann