Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Cell Receptors

Chemistry of recoptor binding, modulators, agonist and antagonists

Most receptors are located in... the cell membrane
Receptors are activated by... Chemical messengers
Chemical messengers include _____ and ______ neurotransmitters and hormones
Binding of messenger to receptor results in _______ _______ Signal transduction
Drug that mimics natural messenger is an _____ agonist
Agonist should bind and leave quickly or slowly? quickly
Drug that blocks natural messenger is an _____ antagonist
Antagonists alter induced fit due to _____ and/or _____ binding groups stronger and/or more binding groups
Agonist must have correct ____ , ______ and ____ _____ in order to work correct shape , positioning and binding groups
Enantiomers usually have ______ biological properties different
Agonists usually have _____ of interactions as natural messenger same #
Groups that block access to binding site are called ______ or ______ steric blocks or steric shields
Agents which bind to allosteric binding site rather than the messenger binding site allosteric modulators
Allosteric modulators _______ receptor activity enhance
Ex. of Allosteric modulator benzodiazepines
Benzodiazepines target allosteric site of GABAa receptor
Reversible antagonist binds _____ to receptor and produces different ____ ___ reversibly , induced fit
Does antagonist undergo rxn with receptor? no rxn
Level of antagonism depends on _____ of binding and _______ strength and [antagonist]
For reversible antagonist: increasing [messenger].... lowers antagonism
Irreversible antagonists bind _____ to receptor by form ______ bonds irreversibly , covalent
For irreversible antagonists: increasing [messenger]... does not reverse antagonism
Allosteric antagonist bind ______ to _______ site of receptor reversibly , allosteric
Alloseric antagonist work by.... altering shape of receptor to block messenger action
For Allosteric antagonists: increasing [messenger]... does not reverse antagonism
How does Antagonism by Umbrella effect work? Antagonist binds to neighboring binding site and overlaps/covers messenger binding site
______ ______ binds but does not produce maximum effect Partial agonist
Partial agonists act as _____ to one receptor subtype and ______ to different subtype agonist , antagonist
Define Inherent activity any activity present in the absence of a chemical messenger
Inverse agonist blocks ______ ______ of receptor inherent activity
Inverse agonist create equilibrium between ______ activity and _______ inherent activity and inactivity
Adding agonist pushed receptor toward _____ form active
Adding antagonist pushes receptor toward ____ form inactive
Adding partial agonist pushes receptor toward ______ between forms equilibrium
Receptors become ____ after long-term exposure to agonist desensitized
Prolonged binding of agonist leads to ______ of receptor phosphorylation
Phosphorylation _______ receptor until agonist leaves deactivates
Receptors become ______ after long-term exposure to antagonist sensitized
To compensate for antagonist-blocked receptors, cell.... synthesizes new receptors
Synthesis of new receptors makes cell more sensitive to _______ natural messenger
Long-term exposure to agonist can lead to ______ and ______ tolerance and dependence
Tolerance results in need to.... increase dosage of antagonist
Dependence results from ______ symptoms when antagonist is taken away withdrawal
Estradiol binding to estrogen receptor results in _______ and exposure of _____ dimerization , AF-2 regions
_______ binds to AF-2 regions of estrogen receptor in order to activate response Coactivator
Raloxifene is an estrogen receptor ______ and ______ agent antagonist and anti-cancer
Raloxifene works by preventing ______ so _____ regions are not exposed and coactivator doesn't bind dimerization , AF-2
Tamoxifen is an estrogen receptor ______ antagonist
Created by: kristin_leann



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards