Pharm 28 Reproductiv Word Scramble
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Question | Answer |
GnRH receptor agonist used to stimulate ovulation and test for hypogonadism | Gonadarelin |
GnRH receptor antagonist (2) | cetrorelix, ganirelix |
GnRH receptor agonists used in Breast/prostate CA, endometriosis etc (4) | Goserelin, Histrelin, Leuprolide, Nafarelin |
GnRH agonist that can cause pituitary apoplexy | leuprolide |
2 GnRH agonists that can cause DVT | goserelin, leuprolide |
2 GnRH antagonists that are used to induce ovulation | ganirelix and Cetrorelix |
GnRH antagonist that can cause spontaneous abortions | ganirelix |
GnRH antagonist that can cause anaphylaxis | cetrorelix |
How to inhibit LH and FSH release | constant GnRH agonist |
How to stimulate LH and FSH release | intermittent GnRH agonists |
Used for BPH and androgenic alopecia | finasteride |
MOA of finasteride | inhibits type II 5α-reductase |
2 irreversable aromatase inhibitors | Formestane and exemestane |
2Reversable aromatase inhibitors | anastrozole and letrozole |
4 serious SE of aromatase inhibitors | osteoporotic Fx, hypercholesterolemia, profuse vaginal bleeding, thrombophlebitis |
Drug used for infertility secondary to ovulatory disorder | clompiphene |
Estrogen receptor antagonist in the breast with partial agonist in endometrium and bone | tamoxifen |
MOA of clomiphene | estrogen receptor antagonist in hypothalamus, anterior pituitary, partial in ovaries |
Estrogen receptor agonist in bone and antagonist in uterus and breast | |
SERM that can cause CVA | tamoxifen |
Used in post menopausal women w/ non-responsive anti-estrogen Tx breast cancer | fulvestrant |
Estrogen receptor antagonist with no agonist activity | fulvestrant |
MOA of Flutamide | competitive inhibitor of androgen receptor |
Used with metastatic prostate cancer or BPH, best with castration | Flutamide |
MOA of spironolactone | aldosterone and androgen receptor antagonist |
MOA of Mifepristone | progesterone antagonist |
Used for abortion | mifepristone/RU-486 |
2 progestins with highest androgenic effects | norgestril and levonorgestril |
Synthetic progestin with anti-androgenic action | drosperinone |
Used in the “morning after” pill | levonorgestrel |
What drug is used with a silastic implant good for 3 years of birth control | etonogestrel |
Can be given parenterally ever 3 months for birth control | Medroxyprogesterone acetate |
Used as progestin-only contraceptive (2) orally available | Norgestrel, norethindrone |
Created by:
csheck
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