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Pharm 28 Reproductiv
LECOM Pharm Ch 28 Reproductive
| Question | Answer |
|---|---|
| GnRH receptor agonist used to stimulate ovulation and test for hypogonadism | Gonadarelin |
| GnRH receptor antagonist (2) | cetrorelix, ganirelix |
| GnRH receptor agonists used in Breast/prostate CA, endometriosis etc (4) | Goserelin, Histrelin, Leuprolide, Nafarelin |
| GnRH agonist that can cause pituitary apoplexy | leuprolide |
| 2 GnRH agonists that can cause DVT | goserelin, leuprolide |
| 2 GnRH antagonists that are used to induce ovulation | ganirelix and Cetrorelix |
| GnRH antagonist that can cause spontaneous abortions | ganirelix |
| GnRH antagonist that can cause anaphylaxis | cetrorelix |
| How to inhibit LH and FSH release | constant GnRH agonist |
| How to stimulate LH and FSH release | intermittent GnRH agonists |
| Used for BPH and androgenic alopecia | finasteride |
| MOA of finasteride | inhibits type II 5α-reductase |
| 2 irreversable aromatase inhibitors | Formestane and exemestane |
| 2Reversable aromatase inhibitors | anastrozole and letrozole |
| 4 serious SE of aromatase inhibitors | osteoporotic Fx, hypercholesterolemia, profuse vaginal bleeding, thrombophlebitis |
| Drug used for infertility secondary to ovulatory disorder | clompiphene |
| Estrogen receptor antagonist in the breast with partial agonist in endometrium and bone | tamoxifen |
| MOA of clomiphene | estrogen receptor antagonist in hypothalamus, anterior pituitary, partial in ovaries |
| Estrogen receptor agonist in bone and antagonist in uterus and breast | |
| SERM that can cause CVA | tamoxifen |
| Used in post menopausal women w/ non-responsive anti-estrogen Tx breast cancer | fulvestrant |
| Estrogen receptor antagonist with no agonist activity | fulvestrant |
| MOA of Flutamide | competitive inhibitor of androgen receptor |
| Used with metastatic prostate cancer or BPH, best with castration | Flutamide |
| MOA of spironolactone | aldosterone and androgen receptor antagonist |
| MOA of Mifepristone | progesterone antagonist |
| Used for abortion | mifepristone/RU-486 |
| 2 progestins with highest androgenic effects | norgestril and levonorgestril |
| Synthetic progestin with anti-androgenic action | drosperinone |
| Used in the “morning after” pill | levonorgestrel |
| What drug is used with a silastic implant good for 3 years of birth control | etonogestrel |
| Can be given parenterally ever 3 months for birth control | Medroxyprogesterone acetate |
| Used as progestin-only contraceptive (2) orally available | Norgestrel, norethindrone |
Created by:
csheck
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