Biochem-AA Metabol Word Scramble
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Question | Answer |
why can't you measure uncongjugated bilirubin directly? | it is still attached to albumin |
what are the 10 essential amino acids? | PVTTIMHALL (Phenylalanine, Valine, Tryptophan, Threonine, Isoleucine, Methionine Histidine, Arginine, Lysine, Leucine) |
what are the only possiuble sources of essential amino acids? | protein turnover and diet |
what are some products of amino acids? | purines, pyrimidines, porphyrins, and neurotransmitters |
what is a positive or negative nitrogen balance? | input>output; output>input |
tyrosine is synthesized from what essential amino acid? | phenylalanine |
what is an example of a porphyrin? | heme |
carbon portions of amino acid degradation can be used to make what? | fatty acids, ketones, glucose |
alanine, aspartate, and glutamate are made from transamination of what? | pyruvate, oxaloacetate, and a-ketoglutarate |
where is arginine created? | in the urea cycle |
where does cysteine get its sulfur from? | methionine |
what are the 3 cofactors required for amino acid synthesis? | pyridoxal phosphate (PLP), tetrahydrofolate, and tetrahydrobiopterin |
what is pyridoxal phosphate (PLP) made from? | B6 |
in what 2 ways is nitrogen removed from amino acids? | deamination and transamination |
what is the main difference between deamination and transamination? | deamination produces ammonia |
aminotransferases are also called what? what do most aminotransferases require as a cofactor? | transaminases; pyridoxal phosphate (PLP) |
what are the roles of alpha-ketoglutarate and glutamate in transamination? | amino acid gives its amino group to alpha-ketoglutarate to produce glutamate |
what are the 2 important transaminases? what are their reversible products? | ALT and AST; alanine<->pyruvate and oxaloacetate<->aspartate |
if liver function is impaired, what will happen to albumin? | it is also impaired |
what does glutamate dehydrogenase do? | it deaminates glutamate to produce alpha-ketoglutarate |
glutamate and an extra ammonia form what molecule? what enzyme does this? | glutamine; glutamine synthase |
in the liver, glutamine is broken down into glutamate and an extra ammonia how? | glutaminase |
aside from glutamate, what other molecule can transport ammonia to the liver? | alanine |
what are the roles of pyruvate and ALT in alanine transporting ammonia to the liver? | pyruvate will take the ammonia from glutamate via ALT, becoming alanine; it then transports the ammonia to the liver, where it gives the ammonia back to glutamate |
which amino acids are ultimately degraded to pyruvate or TCA cycle intermediates, glucogenic or ketogenic? | glucogenic |
which amino acids are ultimately degraded to acetyl CoA or acetoacetate, glucogenic or ketogenic? | ketogenic |
which hormone promotes amino acid uptake and protein synthesis? which hormone induces ubiquitin synthesis to stimulate gluconeogenesis? | insulin; cortisol |
which 2 hormones stimulate amino acid uptake into the liver? | cortisol and glucagon |
what is a state of increased body fuel usage? | hypercatabolic |
what enzyme converts bicarbonate and ammonia into carbamoyl phosphate? which step is this in the urea cycle? | carbamoyl phosphate synthase 1; first |
which enzyme converts carbamoyl phosphate and ornithine into citrulline? which step is this in the urea cycle? | ornithine transcarbomylase; second |
arginine is essential for what process? | growth only |
in the urea cycle, you need what amino acid to make what tca cycle product? | aspartate; fumarate |
what are the two important products of the urea cycle? | arginine and fumarate |
where do the nitrogens come from in the urea cycle? | 1 from ammonia; 1 from aspartate |
in the urea cycle, what molecule gets regenerated? | ornithine |
urea cycle regulation is primarily what kind of loop? | feedforward |
what synthesizes n-acetylglutamate (NAG)? | glutamate or acetyl coa |
what is n-acetylglutamate's effect on CPS1? | allosteric regulator |
what are the two possible fates of urea? | filtered and urinated by kidney; broken down by bacteria into ammonia and put back through the cycle |
what happens to BUN in kidney failure? liver failure? | elevated; reduced |
what is the common precursor of both ammonia and aspartate? | glutamate |
what is the most common urea cycle disorder? | otc |
otc is what kind of hereditary disease? | x-linked |
Created by:
mhassan
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