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NEURONAL AND ENDOCRINE SYSTEM

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Question
Answer
neuronal vs. hx communication   neuronal - rapid and direct hx - slower and non-specific and long-lasting  
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Paracrine system   local mediators (px a.a. or f.a. derivatives) released into interstitial fluid --> NOT HORMONES  
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Give example of hx from paracrine system and what does it do   prostaglandins - smooth muscle contraction, inflammation  
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Why is paracrine system different than endocrine system?   hx are not produced at discrete site but in many places in body  
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What are nx dependent upon for energy? Does it depend on insulin to get glucose?   -glucose and aerobic respiration (no glycogen) -no  
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Where does action potential originate?   axon hillock  
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What is sodium / potassium pump?   pump 3 Na+ out for 2 K+ in  
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When do voltage-gated K channels start to open?   When Na+ channels start to close  
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When is the cell at a resting potential?   when rate of Na+ passively diffusing back into cell = rate being pumped out  
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Is the Na/K pump ever NOT working?   NO  
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Is electrical synapse bidirectional / unidirectional and where can it be found?   -bidirectional -cardiac muscle and visceral smooth muscle  
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Is chemical synapse bi/uni directional and where can it be found?   -unidirectional -motor end plate (connect nx with muscle)  
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Brownian motion   random motion of molecules  
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What is slowest step in transferring nervous signal?   Ca2+ mediated ntm release  
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Does ntm enter postsynaptic cell?   NO --> ntm attaches to rx and postsynaptic mem becomes more permeable to ions or acts via 2nd messenger  
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How to get rid of enzyme (3)?   1.) enzyme destroy 2. presynpatic recycling 3. diffuse out  
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Can a synapse release more than one ntm and both excite/inhibit?   NO  
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Can a single ntm both inhibit and excite?   YES  
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How does AcH act on heart vs. smooth muscle of intestine?   inhibitory / excitatory  
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Neuroglia?   capable of cx division and can multiply to fill space caused by brain injury  
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Microglia & oligodendrocytes   -phagocytize microbes and debris in CNS -create myelin sheaths (only found in vertbrates) in CNS  
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Where are sensory/afferent nx located? Motor/efferent nx?   dorsally (back) ventrally (front)  
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2 divisions of nervous system and what are they?   -CNS-brain and spinal cord -PNS-everything outside of brain and spinal cord / connects CNS to limbs and organs  
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What does PNS break into and what are they controlled by? Where do they receive signal from?   -Somatic nervous system (voluntary) -autonomic nervous system (involuntary - controlled by hypothalamus)  
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What does ANS break into?   -parasympathetic (rest and digest) -sympathetic (flight or fight)  
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Nucleus vs. ganglion   cell bodies located in CNS vs. cell bodies located outside CNS  
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postganglionic sympathetic nx. vs. postsympathetic paras. nx.   lie far from effectors vs. lie near effectors  
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Somatic nervous system 1. Once nerve fibers leave CNS, synapse where? 2. What does it release? 3. What does it innervate? 4. Excitation / inhibition   1. Once nerve fibers leave CNS, don't make synapse till effector organ 2. release AcH 3. innervates skeletal muscle 4. excitation  
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Autonomic nervous system 1. Once nerve fibers leave CNS, synapse where? 2. What does it release in preganglionic? Postganglionic? 3. What does it innervate? 4. Excitation / inhibition   1. nerve fibers leaving CNS synapse with ganglion before effector organ 2. preganglionic PNS and sympathetic both release AcH ---> postganglionic para. : AcH ---> postganglionic sympathetic: Norepi / epi 3. glands, smooth and cardiac muscle 4. both  
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AcH is used in? Norepi / epi is used in?   -SNS and PNS -SNS only  
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Where are internx mostly found? Sensory and motor nx?   CNS PNS  
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Path of light once it strikes eye?   cornea --> aq. humor--> pupil --> lens --> vitreous humor --> retina  
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Where does light bend most when it enters eye?   Cornea = refractive index of 1.4  
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How does iris regulate amount of light that enters eye?   ciliary muscle  
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What happens when ciliary muscle contracts? Relaxes? (circle opening, shape of lens, focal point)   -circle opening decreases, lens more spherical, bring focal point closer to lens -lens flattens, increase focal distance, circle opening increases  
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What type of lens is eye?   -converging/convex --> real and inverted image -object must be outside focal distance  
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Fovea and what is it made of?   mostly cones and most accurate vision  
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What are rods made of? What happens when light strikes rods?   -rhodopsin -photon strikes retinal in rhodopsin, causes hyperpolarization, transduced into neural signal to brain  
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What is the precursor for all pigments in rods and cones?   vitamin A  
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Process of sound waves from start --> mvmt of fluid in cochlea.   hit pinna - vibrate tympanic ear drum - vibrate middle ear bones (MIS) - vibrate oval window - mvmt fluid in cochlea  
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What happens once cochlea fluid moved?   -vibration of basilar mem -stereocili microvilli "hair" cx bend in organ of corti -influex of K+ --> voltage positive -Ap generated in auditory nerve -AP relayed to brain --> hearing!  
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Why is oval window smaller than tympanic membrane?   -to increase pressure -greater force required to transfer sound from air to perilymph  
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Semicircular canals   -sense position and mvmt of head -balance -3 are perpendicular to each other  
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endocrine vs. exocrine   -endocrine-release hx into env't through ducts -exocrine-release sweat, oil, enzymes directly into body fluids  
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What do hx ABSOLUTELY need?   receptors!  
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What are 3 basic types of hormones and how do they act?   -peptide (2nd messenger) -steroid (nuclear rx) -tyrosine (nuclear rx)  
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Where are all peptide hx made?   -preprohx (rough ER) --> prohx (ER lumen) --> hx (Golgi)  
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Whether it be ntm or protein hx, what happens when it attaches to rx?   1. opens ion channels 2. activates 2nd messenger  
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Is 2nd messenger ALWAYS excitatory?   no  
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Where do steroid hx come from?   adrenal cortex, gonads, placenta  
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What are major types of tyrosine derivatives?   -T3 and T4 -catecholamines from adrenal medulla  
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What kind of hx are catecholamines?   -px and act through 2nd messenger cAMP  
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What controls pituitary glands?   hypothalamus  
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What do steroid hx cause?   promotes transcription of specific genes  
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Do a.a. hx or steroid hx have longer-lasting actions?   steroid hx  
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What terminates cAMP action?   phosphodiesterase  
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What hx are ovaries under control of?   GNRH --> LH and FSH  
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Diabetes mellitus vs. diabetes insipidus   -mellitus-lack of insulin or resistance to it -insipidus-kidneys unable to conserve water (defect in secretion of ADH)  
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Diabetics have (2) sx related to insipidus and mellitus.   1. polyuria - increased urination 2. polydipsia - increased thirst  
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2 types of diabetes mellitus   Type I (insulin-dependent) -autoimmune destruction of beta cells Type II (non-insulin dependent) -body resists effects of insulin -most common  
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Where is somatostatin made? What does it do?   stomach, intestines, and pancreas -inhibit GH, insulin, and glucagon -decrease rate of gastric emptying to extend time nutrients are absorbed  
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How is bile released into duodenum?   bile stored in gall bladder joins with common bile duct --> joins pancreatic duct --> duodenum  
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What are 3 types of cells found in pancreas?   -alpha (glucagon) -beta (insulin) -delta (somatostatin)  
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What else can increase plasma glucose besides insulin?   glucocorticoids, epi, and growth hx  
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Can insulin and glucagon enter cells?   NO  
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Are nx in brain affected by insulin?   NO  
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Where are adrenal glands located and what are they separated into?   -top of kidneys -adrenal cortex and adrenal medulla  
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What does adrenal cortex secrete?   -corticosteroids (steroid hx) -sugar, salt, sex -glucocorticoids, mineralocorticoids, cortical sex hx  
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What does glucocorticoid do and what is major type?   -cortisol -increase blood glucose conc and decrease protein synthesis  
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What does mineralocorticoid do and what is major type?   -aldosterone -reabsorbs sodium, secretes K+ and H+ to increase BP by acting on distal convoluted tubuel  
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What does cortical sex hx do in males and females ?   -make androgen -masculanizing effects in female  
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What does adrenal medulla make?   norepinephrine and epinephrine (catecholamines = protein hx) --> tyrosine derivatives (D--> N --> E)  
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How does (nor)epinephrine act on internal organs and skin? On skeletal muscle?   -vasoconstrictors -vasodilators  
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What stimulates aldosterone and increases BP via vasoconstriction?   angiotensin II  
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What does parathyroid hx do in kidney, gut, and bone?   -decrease excretion of calcium through kidney, increase secretion of phosphate -increase absorption of calcium in gut --> activate Vitamin D and excrete K+ -increase bone resorption and recruitment of osteoclasts  
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How does PTH act on osteoclasts?   -PTH acts on osteoblasts which produces RANKL to stimulate osteoclasts  
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PTH _____ calcium levels, calcitonin ____calcium levels   -increase and decrease  
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2 major roles for thyroid gland   -set metabolic rate -calcium homeostasis  
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What kind of hx are T3 and T4 and what do they do?   -nuclear hx -increase basal metabolic rate and increase cx respiration  
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hypothyroidism and sx   -deficiency of iodine and decreased thyroid hx -lethargy and low metabolism  
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hyperthyroidism and sx   -tumor / thyroid over-stimulation -over activity  
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goiter   enlarged thyroid as result of hypo/hyperthyroidsm  
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calcitonin actions on kidney, gut, bone   -increase excretion of calcium from kidneys -decreases absorption from gut -decreases osteoclast activity and increases storage in bone  
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Main fxns of calcium   -bone -muscle contraction -normal blood clotting co-factor -cell mvmt and ntm release  
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anterior pit hx are ____ and ____   -direct-act directly by binding to rx -tropic - bind to rx and cause release of effector hx  
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direct hx   Prolactin Endorphins Growth hx  
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where does growth occur in bones?   epiphyseal plates of long bones  
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Tropic Hx   FSH LH ACTH TSH  
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ACTH   -adrenocorticotroic hx -stimulates adrenal cortex to release glucocorticoids via cAMP  
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What stimulates adrenal medulla?   sympathetic and parasympathetic activity  
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Hx of posterior pituitary   -oxytocin - milk ejection and uterine contractions -ADH - aka vasopressin and causes collecting ducts of kidney to become permeable to water  
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What is ADH secreted in response to? (brain receptors)   -osmoreceptors - increased blood osmolarity -baroreceptors - decreased blood volume  
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Prolactin is released in absence of_______   prolactin inhibiting factor  
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What do coffee and beer affect in renal system?   block ADH --> increase urine volume  
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Why isn't prolactin produced before birth? What does lactation block?   -inhibitory effects of P and E -menstrual cycle  
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Where do most synapses occur?   on dendrites  
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Does the cell body of a neuron have a nucleus and organelles?   YES!  
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Myelin sheath and why is it a good insulator?   -covers axon intermittently with nodes of Ranvier gaps -fatty and has no channels  
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Schwann cells   makes myelin sheath in the peripheral nervous system by wrapping around axon  
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Schwan cx vs. oligodendrocytes   -Schwann cx act in peripheral nervous system -oligodendrocytes act in central nervous system  
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What is benefit of saltatory conduction?   speeds up AP conduction in axon  
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Axodendritic synapse   axon terminal --> dendrite  
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Axosomatic synapse   axon terminal --> cx body  
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Axoaxonic synapse   axon terminal --> axon hillock  
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Brief summary of ntm --> ATP   ntm leaves presynaptic through vesicles triggered by calcium, binds to rx, opens up channel on postsynaptic that causes change in mem potential  
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Examples of ntm   ATP, AcH, NE, dopamine  
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What are synaptic knobs?   another name for axon terminal  
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What causes fatigue in a nx?   continous synaptic activity --> depletion of ntm --> fatigue  
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Defining characteristic of AP   all or nothing!  
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What does the resting mem potential hope to achieve?   negative inside, positive outside / sodium outside, potassium inside  
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How does resting mem potential achieve negative inside?   Na/K pump and K channel leakage  
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What happens during depolarization?   sodium channels open and positive sodium rushes inside  
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What happens during repolarization?   potassium channels open and sodium channels close , potassium rushes outside  
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What happens during hyperpolarization?   K channels don't close fast enough so mem potential drops below  
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When does absolute refractory period occur? Relative refractory period?   -depolarization to cx re-establish original resting state -after hyperpolarization till resting state re-established  
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What does "all-or-none" mean?   All AP have the same magnitude NO MATTER WHAT  
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excitatory synapse   ntm binding causes postsynaptic potential to be more positive (depolarization) --> AP  
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inhibitory synapse   ntm binding causes postsynaptic potential to be more negative (hyperpolarization)  
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Endocrine vs. exocrine   -endocrine - hx, no duct, acts long distances -exocrine - non-hx secretion into ducts  
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What does pineal gland make?   melatonin  
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What does thyroid gland make?   thyroid hx and calcitonin  
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What does adrenal gland make?   -medulla - epi and norepi -cortex - mineralocorticoids / glucocorticoids  
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What does dopamine inhibit?   prolactin  
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Where is aldosterone made?   adrenal cortex  
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Parathyroid vs. calcitonin   parathyroid increases bone resorption while calcitonin puts calcium back in  
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What does thymus do?   stimulates T-cx to develop  
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What is major type of glucocorticoid?   cortisol --> increase blood sugar  
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Does ovary make testosterone?   small amount  
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What is the result of diabetes?   -glucose can't enter cx --> high blood sugar -cx starved of sugar --> f.a. metabolism  
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What does f.a. metabolism in diabetes result in?   ketone bodies --> ketoacidosis (acidic blood)  
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Why do diabetes pee more?   sugar in urine leads to more water in urine from osmosis  
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gigantism   too much GH during growing age --> well-proportioned giants  
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acromegaly   too much GH later on in life --> disproportioned growth of certain areas of body that still respond to GH  
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The major types of hx are ______ and steroids   a.a.  
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cAMP path   a.a. binds mem rx, G-px, adenylate cyclase activated, cAMP made, protein kinase cascade  
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What types of hx can go directly into cx? Where does it bind?   -steroid and thyroid hx -binds rx in cytoplasm or nucleus  
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Phospholipid path   a.a. binds mem rx, G-px, phospholipase C activated, mem phospholipid split into DAG and IP3 -DAG triggers px kinase cascade -IP3 releases Ca from the ER  
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What creates specificity of hx for target cx?   whether or not there are rx for hx  
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Humoral control of hx   glands directly respond to chemical levels in the blood -parathyroid and low Ca  
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Neural control of hx   glands release hx when stimulated by nerves -flight or fight  
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Hormonal control of hx   glands release hx when stimulated by other hx -tropic hx  
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Sensory = __________. Motor = ___________.   -afferent to CNS -efferent away from CNS  
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Sympathetic is ________. Parasympathetic is ______.   -flight or fight -rest and digest  
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Examples of positive feedback.   -LH and estrogen surge -oxytocin and contractions -blood clotting platelets  
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What is reflex arc?   receptor - sensory nx - integration center - motor nx - effector  
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Why do reflexes bypass the brain?   creates faster response -brain still aware of what is happening  
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monosynaptic vs. polysynaptic   -monosynaptic - no internx / direct synapse of sensory to motor -polysynaptic - internx present  
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During knee jerk, the ____ is contracted and the ______ is relaxed.   -extensor -flexor  
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What does the golgi tendon reflex protect?   protects muscle from heavy loads by causing muscle to relax and drop the load  
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What happens during the golgi tendon reflex?   nx from golgi tendon organ fires, motor nx inhibited, muscle relaxes, load dropped  
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What is role of spinal cord in reflex arc?   provides synapse(s) for reflex arc  
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What does efferent control refer to in reflex arc?   brain can still override spinal reflexes  
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Where in the skin are the touch, heat, and pain rx located? Pressure rx?   -close to surface near dermis-epidermis boundary -deeper in dermis  
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Proprioreceptor   -senses position of a body part -controlled by cerebellum  
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What do thermoreceptors detect?   A CHANGE in temperature  
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Olfaction process   chemicals enter nose, trapped in mucus, picked up by mem rx on cilia, cx depolarization  
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Taste process   Chemical dissolve in saliva, carried inside taste bud, microvilli pick up chemicals, release ntm to brain  
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What are inner ear bones?   malleus(hammer) , incus (anvil) , stapes (stirrup)  
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What is the ear drum?   tympanic membrane  
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What is vestibule in hear?   contacts oval window and continuous with semicircular canals --> balance  
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What is main fxn of cochlea?   propagates sound pressure waves in fluid and transduces them into nerve impulses sent to brain  
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Which is more sensitive: rods or cones?   rods  
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What is importance of rhodopsin and what is it made of?   -chemical responsible for light reception -retinal + opsin  
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Light converts ____(cis/trans) retinal --> _____(cis/trans) retinal   cis --> trans  
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What is blind spot?   Where bundle of nerves exist in back of retina that sends signal to brain  
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How does brain create 3D image?   combines 2 images from each eye (also to get rid of blind spot)  
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How many nx do the sympathetic and parasympathetic system rely on?   2  
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Describe the nx in a sympathetic nervous system.   short preganglionic and long postganglionic  
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Describe nx in a parasympathetic n.s.   long preganglionic and short postganglionic  
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Where is oxytocin and ADH produced?   hypothalamus  
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What is aldosterone produced in response to?   low sodium or elevated potassium  
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Which division of autonomic nervous system has dominant effect on heart?   parasympathetic nervous system  
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How is the GI tract an endocrine gland?   secretes secretin, CCK, gastrin  
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How are kidneys an endocrine gland?   secrete erythropoietin to stimulate bone marrow to make RBC  
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How is heart an endocrine gland?   secretes ANP to regulate salt and water balance  
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How is thymus an endocrine gland?   secretes thymosin to regulate proper T-cx differentiation  
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Totipotent cx   any one of these cx could make complete organism  
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What is special about a morula?   has totipotent cx  
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blastula vs. blastocyst   blastocyst is mammalian blastula type  
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blastocoel   hollow, fluid-filled cavity  
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trophoblast   surrounds blastocoel and makes chorion and placenta  
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inner cx mass   makes actual organism  
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Which occurs first, determination or differentiation?   determination  
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Where is the adrenal cortex formed from?   mesoderm  
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Where is the adrenal medulla formed from?   ectoderm  
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Deuterosome vs. protosome   -deuterosome = human -protosome = everything else  
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What does the blastopore become in deuterosomes vs. protosomes?   -deuterosome = anus -protosome = mouth  
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What does archenteron develop into?   gut  
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What do neural crest cx form?   peripheral nervous system  
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umbilical arteries   carry deoxygenated blood away from fetus  
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umbilical veins   carry oxygeanted blood towards fetus  
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ductus venosus   -shunts 1/2 of oxygenated blood from umbilical vein to inferior vena cava -bypass nonfxnal liver -preferentially give oxygenated blood to brain  
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foramen ovale   connects right and left atria  
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ductus arteriosus   connects pulmonary artery --> aorta -bypasses nonfxnal lungs  
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Why does sympathetic system produce more whole-body response?   ganglia are connected to each other  
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What are trophic hx?   stimulate other glands to secrete hx  
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When Na/K pump is blocked, what will be intracx conditions?   -increase in intracx sodium -decrease in intracx K  
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When Na/K pump is blocked, what also is blocked?   ATP consumption  
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What are 3 major px in plasm?   albumin, gammaglobulins (antibodies, fibrinogen  
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Secondary px structure   alpha helix or beta sheet  
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What are the 2 major systems that maintain homeostasis?   endocrine and nervous system  
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What are the parts of a pancreas?   head, neck, body, tail  
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What does low Ca cause?   increases nx permeability to sodium --> hyperexcitability  
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What stimulates osteoblasts?   calcitonin  
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Small intestine: parathyroid vs. calcitonin   -parathyroid increases Ca absorption -calcitonin decreases Ca absorption  
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How does Vit D act on intestine?   increases Ca absorption  
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What does shortage of insulin crease?   cause blood glucose level to increase and glycolysis to decrease  
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What happens if there is a decrease in rate of glycolysis in relation to ketone bodies?   -forces body to metabolize fat --> ATP -fat metabolism = ketone bodies  
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What stimulates the release of estrogen?   LH  
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Where are gap junctions found?   heart and smooth muscle  
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What does thyroid hx stimulate?   px synthesis and activity of Na/K ATP ase  
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What does atrial natiuretic peptide do?   decrease blood volume  
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2 characteristics of cancer   -abnormal cell growth -abnormally high conc. of product  
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Calcitonin actions with Ca and P   1. blocks bone resorption 2. inhibits renal absorption of Ca and P  
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Parathyroid actions with Ca and P on bone, kidney, and s. intestine   -bone = releases Ca and P -kidney = decreases excretion of Ca, increases P -s. intestine = increases reabsorption of Ca and P  
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Overall what does PTH do?   increases blood calcium, and decreases blood phosphate  
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What hx is in excess with someone with high sugar level and muscle wasting?   excess cortisol  
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What are the 4 hx that increase blood glucose levels?   glucagon, cortisol, GH and epi  
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facilitated diffusion   relies on a channel px to move down a concentration gradient  
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Does endocytosis depend on ATP?   yes  
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What kind of gland is the salivary?   exocrine gland  
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Which is stronger: ionic or covalent bond   ionic  
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What are the tyrosin-deriv a.a.?   thyroid hx, epi, and norepi  
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What are the steroid hx?   cortisol, aldo, progesterone, testosterone  
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Where is AcH used?   -parasympathetic NS -neuromuscular jxns to stimulate voluntary muscles  
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What does the PNS and SNS both release?   acetylcholine at preganglionic nerve  
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Does calcitonin increase phosphate reabsorption in kidneys?   NO  
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If the Na/K pump was not working, what would be the conditions?   built up of Na inside, built up of K outside  
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