LECOM Pharm Ch 28 Reproductive
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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GnRH receptor agonist used to stimulate ovulation and test for hypogonadism | Gonadarelin
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GnRH receptor antagonist (2) | cetrorelix, ganirelix
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GnRH receptor agonists used in Breast/prostate CA, endometriosis etc (4) | Goserelin, Histrelin, Leuprolide, Nafarelin
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GnRH agonist that can cause pituitary apoplexy | leuprolide
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2 GnRH agonists that can cause DVT | goserelin, leuprolide
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2 GnRH antagonists that are used to induce ovulation | ganirelix and Cetrorelix
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GnRH antagonist that can cause spontaneous abortions | ganirelix
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GnRH antagonist that can cause anaphylaxis | cetrorelix
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How to inhibit LH and FSH release | constant GnRH agonist
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How to stimulate LH and FSH release | intermittent GnRH agonists
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Used for BPH and androgenic alopecia | finasteride
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MOA of finasteride | inhibits type II 5α-reductase
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2 irreversable aromatase inhibitors | Formestane and exemestane
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2Reversable aromatase inhibitors | anastrozole and letrozole
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4 serious SE of aromatase inhibitors | osteoporotic Fx, hypercholesterolemia, profuse vaginal bleeding, thrombophlebitis
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Drug used for infertility secondary to ovulatory disorder | clompiphene
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Estrogen receptor antagonist in the breast with partial agonist in endometrium and bone | tamoxifen
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MOA of clomiphene | estrogen receptor antagonist in hypothalamus, anterior pituitary, partial in ovaries
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Estrogen receptor agonist in bone and antagonist in uterus and breast |
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SERM that can cause CVA | tamoxifen
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Used in post menopausal women w/ non-responsive anti-estrogen Tx breast cancer | fulvestrant
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Estrogen receptor antagonist with no agonist activity | fulvestrant
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MOA of Flutamide | competitive inhibitor of androgen receptor
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Used with metastatic prostate cancer or BPH, best with castration | Flutamide
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MOA of spironolactone | aldosterone and androgen receptor antagonist
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MOA of Mifepristone | progesterone antagonist
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Used for abortion | mifepristone/RU-486
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2 progestins with highest androgenic effects | norgestril and levonorgestril
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Synthetic progestin with anti-androgenic action | drosperinone
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Used in the “morning after” pill | levonorgestrel
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What drug is used with a silastic implant good for 3 years of birth control | etonogestrel
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Can be given parenterally ever 3 months for birth control | Medroxyprogesterone acetate
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Used as progestin-only contraceptive (2) orally available | Norgestrel, norethindrone
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