3rd packets
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| What organ involves hepatitis? | Liver
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| What family does Hepatitis A (HAV)? | Piconaviridae
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| What family does Hepatitis B (HBV)? | Hepadnaviridae
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| What family does Hepatitis C (HCV)? | Flaviviridae
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| What family does Hepatitis D (HDV)? | Deltavirus
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| What are the common symptoms of hepatitis? | Fever, GI symptoms, Nausea and Vomiting
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| Hep A's Mode of transmission? | Fecal-oral, in crowded populations with poor sanitation
Rarely through needles, it's viremia is very short
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| Is Hep A oncogenic, which types are? | No, type B and C are oncogenic
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| Name of the vaccine for Hep A? | Formalin inactivated HAV vaccine
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| What type of DNA is in Hep B and why is it incomplete? | ssDNA positive strand and circular incomplete until it infects a new cell
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| What are the conditions of Hep B? | Cirrhosis and carcinoma of the liver
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| Hep B's Mode of transmission? | Parenteral - Needles, Transplants, tattoo's and even sexually and orally, also mother-son
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| What are the 3 morphologic forms of Hep B, known as the dane particles? | Spherical, Pleomorphic spherical and filamentous
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| What is the outer surface antigen of Hep B? | HBsAg
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| Why is HBsAg important for Hep D? | Because it provides HbsAg envelope for it
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| What is Fulminant Hepatitis? | Combination of Hep B and D (Co-infection)
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| What genes are contained in Hep B? | Transactivator protein X
Polymerase P - (RNase H and reverse transcriptase
S gene - encodes HBsAg
C gene - encodes HBcAg and HBeAg
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| What is cccDNA in Hep B? | covalently closed DNA, it happens after the incomplete DNA closes
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| Types of Vaccine for Hep B? | Recombinant HBsAg vaccine
Hepatitis B immune globulin (Passive)
HBsAG at different site soon after exposure (Active)
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| Medication for Hep B? | Interferon alfa
Antivirals (entecabir, adefovir, lamivudine, ribavirin
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| What is the difference in Hep B infection between effective and limited T cell immunity? | Effective: acute hep
Limited: chronic disease (Cirrhosis or carcinoma)
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| Which hepatitis does not have an arthropod vector? | Hep C
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| How is Hep C transmitted? | Parenteral - transfusion of blood products, semen, mother-son, hemodialysis, sex
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| What is the primary cause of chronic liver carcinoma? | Hep C
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| What is the treatment for Hep C? | Similar to Hep B, Interferon Alfa and ribavirin
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| What are the types of vaccine for hep C? | None
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| Why can't Hep D exist by itself? | Because it needs the envelope of HBsAg, the only gene on the molecule codes for HD-AG
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| What kind of RNA is in HDV? | ssRNA
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| What kind of RNA is in HAV? | ssRNA
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| What kind of RNA is in HBV? | dsDNA
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| What kind of RNA is in HCV? | ssRNA
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| What are the vaccines for HDV? | There is no specific vaccine, it needs HBV to coexist so by targeting HBV the infection can be stopped.
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