LECOM Immuno Ch 11 hypersensitivity
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| Other name; cells and Ab implicated: Type 1 | Immediate hypersensitivity; mast/eosinophils, IgE, TH2
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| Other name; cells and Ab implicated: Type 2 | Antibody-mediated disease; IgG,/IgM Ab on extracellular or cell surface, activated neuts/macrophages
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| Other name; cells and Ab implicated: Type 3 | Immune complex-mediated diseases; immune complexes against vascular basement membranes
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| Other name; cells and Ab implicated: Type 4 | T-cell mediated diseases; delayed with CD4+ T cells w/ macrophage activation; cytolysis w/ CD8+ CTLs
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| Cause and effect of late phase reaction in Type I reactions | mast cell released cytokines recruit neuts and lymphs.
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| What is FcεR1? What 2 cells is it present on? | high affinity IgE Fc receptor; on mast cells and basophils
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| 2 substances from mast cells that cause vascular dilation | vasoactive amines (histamine), prostaglandins
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| Mast cells release these substances to attract neutrophils and eos. | IL-4 and TNF
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| Eosinophils activated by this | IL-5
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| 2 substances from mast cells that cause smooth muscle contraction | vasoactive amines (histamine), Leukotrienes
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| This IL causes increased mucus secretion | IL-13
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| Myasthenia gravis results from autobodies against what? That cause what? | ACh Receptors; inactivating the receptor
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| Graves’ disease results from Auto-Ab against what? Resulting in what? | TSH receptors; activating the receptor in absence of TSH
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| Pernicious Anemia; Ab to? Causes? | Intrisic factor Ab; neutralizes IF and decreases B12 absorption; anemia
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| Ab to e-cadherin causes? | pemphigus vulgaris; skin bullae
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| Ab to kidney and lung BM causes? | Goodpasture’s syndrome; nephritis, lung hemorrhages
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| Arthrus reaction is? | cutaneous vasculitis at injection site of a previous vaccinated person with protein antigen
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| What do superantigens do? | activate large numbers of T cells
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| Poison ivy reaction, tuberculosis, liver injury in hepatitis virus are what type of reactions | T cell medited; type 4
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| Activation of TH1 cells causes what to be released, resulting in what? | releases INF-γ; activating macrophages
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| Activation of TH17 cells causes what? | leukocyte recruitment
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| Type 1 DM: T-cells attack? Genetic? | pancreatic islet cells; insulin gene/PTPN22
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| RA: T-cells attack? Genetic? | unknown Ag in joints; PTPN22
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| Multiple Sclerosis: T-cells attack? Genetic?2 Myelin proteins; CD25 |
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| IBD: T-cells attack? Genetic? | unknown; NOD2
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| Toxic Shock Syndrome: T-cells attack? | superantigens cause massive t-cell response
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