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Immuno 11 Hypersens

LECOM Immuno Ch 11 hypersensitivity

Other name; cells and Ab implicated: Type 1 Immediate hypersensitivity; mast/eosinophils, IgE, TH2
Other name; cells and Ab implicated: Type 2 Antibody-mediated disease; IgG,/IgM Ab on extracellular or cell surface, activated neuts/macrophages
Other name; cells and Ab implicated: Type 3 Immune complex-mediated diseases; immune complexes against vascular basement membranes
Other name; cells and Ab implicated: Type 4 T-cell mediated diseases; delayed with CD4+ T cells w/ macrophage activation; cytolysis w/ CD8+ CTLs
Cause and effect of late phase reaction in Type I reactions mast cell released cytokines recruit neuts and lymphs.
What is FcεR1? What 2 cells is it present on? high affinity IgE Fc receptor; on mast cells and basophils
2 substances from mast cells that cause vascular dilation vasoactive amines (histamine), prostaglandins
Mast cells release these substances to attract neutrophils and eos. IL-4 and TNF
Eosinophils activated by this IL-5
2 substances from mast cells that cause smooth muscle contraction vasoactive amines (histamine), Leukotrienes
This IL causes increased mucus secretion IL-13
Myasthenia gravis results from autobodies against what? That cause what? ACh Receptors; inactivating the receptor
Graves’ disease results from Auto-Ab against what? Resulting in what? TSH receptors; activating the receptor in absence of TSH
Pernicious Anemia; Ab to? Causes? Intrisic factor Ab; neutralizes IF and decreases B12 absorption; anemia
Ab to e-cadherin causes? pemphigus vulgaris; skin bullae
Ab to kidney and lung BM causes? Goodpasture’s syndrome; nephritis, lung hemorrhages
Arthrus reaction is? cutaneous vasculitis at injection site of a previous vaccinated person with protein antigen
What do superantigens do? activate large numbers of T cells
Poison ivy reaction, tuberculosis, liver injury in hepatitis virus are what type of reactions T cell medited; type 4
Activation of TH1 cells causes what to be released, resulting in what? releases INF-γ; activating macrophages
Activation of TH17 cells causes what? leukocyte recruitment
Type 1 DM: T-cells attack? Genetic? pancreatic islet cells; insulin gene/PTPN22
RA: T-cells attack? Genetic? unknown Ag in joints; PTPN22
Multiple Sclerosis: T-cells attack? Genetic?2 Myelin proteins; CD25
IBD: T-cells attack? Genetic? unknown; NOD2
Toxic Shock Syndrome: T-cells attack? superantigens cause massive t-cell response
Created by: csheck