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Immuno 11 Hypersens
LECOM Immuno Ch 11 hypersensitivity
Question | Answer |
---|---|
Other name; cells and Ab implicated: Type 1 | Immediate hypersensitivity; mast/eosinophils, IgE, TH2 |
Other name; cells and Ab implicated: Type 2 | Antibody-mediated disease; IgG,/IgM Ab on extracellular or cell surface, activated neuts/macrophages |
Other name; cells and Ab implicated: Type 3 | Immune complex-mediated diseases; immune complexes against vascular basement membranes |
Other name; cells and Ab implicated: Type 4 | T-cell mediated diseases; delayed with CD4+ T cells w/ macrophage activation; cytolysis w/ CD8+ CTLs |
Cause and effect of late phase reaction in Type I reactions | mast cell released cytokines recruit neuts and lymphs. |
What is FcεR1? What 2 cells is it present on? | high affinity IgE Fc receptor; on mast cells and basophils |
2 substances from mast cells that cause vascular dilation | vasoactive amines (histamine), prostaglandins |
Mast cells release these substances to attract neutrophils and eos. | IL-4 and TNF |
Eosinophils activated by this | IL-5 |
2 substances from mast cells that cause smooth muscle contraction | vasoactive amines (histamine), Leukotrienes |
This IL causes increased mucus secretion | IL-13 |
Myasthenia gravis results from autobodies against what? That cause what? | ACh Receptors; inactivating the receptor |
Graves’ disease results from Auto-Ab against what? Resulting in what? | TSH receptors; activating the receptor in absence of TSH |
Pernicious Anemia; Ab to? Causes? | Intrisic factor Ab; neutralizes IF and decreases B12 absorption; anemia |
Ab to e-cadherin causes? | pemphigus vulgaris; skin bullae |
Ab to kidney and lung BM causes? | Goodpasture’s syndrome; nephritis, lung hemorrhages |
Arthrus reaction is? | cutaneous vasculitis at injection site of a previous vaccinated person with protein antigen |
What do superantigens do? | activate large numbers of T cells |
Poison ivy reaction, tuberculosis, liver injury in hepatitis virus are what type of reactions | T cell medited; type 4 |
Activation of TH1 cells causes what to be released, resulting in what? | releases INF-γ; activating macrophages |
Activation of TH17 cells causes what? | leukocyte recruitment |
Type 1 DM: T-cells attack? Genetic? | pancreatic islet cells; insulin gene/PTPN22 |
RA: T-cells attack? Genetic? | unknown Ag in joints; PTPN22 |
Multiple Sclerosis: T-cells attack? Genetic?2 Myelin proteins; CD25 | |
IBD: T-cells attack? Genetic? | unknown; NOD2 |
Toxic Shock Syndrome: T-cells attack? | superantigens cause massive t-cell response |