Med’11 Biochemistry Enzymes - Cosubstrates, Prosthetic Groups, &Vitamins
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| NADH (& NADPH) | Nicotinamide adenine dinucleotide Precursor: Niacin Defic: Pellagra Role: Redox involving 2-e transfer Enz: Dehydrogenase | ||||
| FAD | Flavin adenine dinucleotide Precursor: riboflavin B2 Defic: growth retardation Role: redox involving 1- and 2-e transfer Enz: flavoenzymes | ||||
| CoA | Coenzyme A Precursor: pantothenate B3 Defic: dermatitis in chicks Role: acyl transfer Enz: 100s of enz | ||||
| TPP | Thiamine Pyrophosphate Precursor: Thiamine B1 Defic: beriberi Role: transfer of 2-C fragment containing carbonyl Enz: some carboxylases | ||||
| PLP | Pyroxidal Phosphate Precursor: pyroxidal, pyroxine, pyroximine B6 Defic: dermatitis in rats Role: transfer of groups to and from A.A. Enz: transaminase | ||||
| Biotin | Biotin Precursor: Biotin Defic: dermatitis in humans Role: carboxyl grp transfer & ATP dependent carboxylation Enz: some carboxylases | ||||
| Tetrahydrofolate | Tetrahydrofolate Precursor: folic acid Defic: anemia, spina befida Role: 1-C transfer Enz: dihydrofolate reductase & others | ||||
| Cobalamin | Cobalamin Precursor: methylcobalamin, adenosylcobalamin Defic: pernicous anemia Role: intermolecular rearrangement, methyl transfer Enz: methylmalonyl-coA mutase; homocysteine methyltransferase | ||||
| Lipoamide | Lipoamide Precursor: lipoic acid Defic: NONESSENTIAL Role: acyl transfer Enz:dihydrolipoamide; acyltransferase | ||||
| Vitamin K | Deficiency: blood clotting disorder Role: carboxylation of Glu Enz: vitamin K-dependent carboxylase | ||||
| Ubquinone | AKA: Coenzyme Q Role: electron transfer Enz: mitochondrial enzyme | ||||
| Vitamin A | Role: Vision Solubility: Lipid Deficiency: Night blindness | ||||
| Vitamin C | Role: Antioxidant Solubility: Water Deficiency: Scurvy | ||||
| Vitamin D | Role: Gene expression Solubility: Lipid Deficiency: Rickets | ||||
| Vitamin E | Role: Antioxidant Solubility: Lipid Deficiency: Fragile blood cells |
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Created by:
Salma Al-Amoudi
on 2011-10-13