clinical neuro 3
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| blocks uncoating of virus | amantadine
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| reason for acyclovir/gancyclovir's highly selective toxicity | they act on viral kinases, so only target infected cells
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| viruses treated w/acyclovir | HSV, EBV, VZV
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| viruses treated w/valacyclovir | recurrent HSV-2 or VZV infections
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| famciclovir is used for | acute herpes zoster and recurrent HSV-2
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| ganciclovir treats | CMV
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| DOC for temporal lobe encephalitis | acyclovir
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| may cause nephrotoxicity | cidofovir
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| MOA of cidofovir | inhibits DNA polymerase; more effective against viral than host cells
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| doesn't require phosphorylation | foscarnet
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| viruses treated w/foscarnet | HSV, VZV, CMV, EBV, HHV-6, HBV, HIV
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| zanamivir age limit | must be >7 yr
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| oseltamivir age limit | must be >1 yr
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| amantadine age limit | must be >1yr
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| rimantadine age limit | adults only
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| MOA of nueraminidase inhibitors | inhibit cleavage of sialic acid, which prevents the release of newly formed viruses
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| MOA of palivizumab | monoclonal Ab that binds to Fusion (F) protein, preventing infection of host cell
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| virus treated by palivizumab | RSV
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| dosing for palivizumab | monthly
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| mechanism of administration for ribavirin | inhaled
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| pts on ribavirin should avoid contact with | pregnant women or women trying to become pregnant
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Created by:
drhermy
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