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antivirals
clinical neuro 3
Question | Answer |
---|---|
blocks uncoating of virus | amantadine |
reason for acyclovir/gancyclovir's highly selective toxicity | they act on viral kinases, so only target infected cells |
viruses treated w/acyclovir | HSV, EBV, VZV |
viruses treated w/valacyclovir | recurrent HSV-2 or VZV infections |
famciclovir is used for | acute herpes zoster and recurrent HSV-2 |
ganciclovir treats | CMV |
DOC for temporal lobe encephalitis | acyclovir |
may cause nephrotoxicity | cidofovir |
MOA of cidofovir | inhibits DNA polymerase; more effective against viral than host cells |
doesn't require phosphorylation | foscarnet |
viruses treated w/foscarnet | HSV, VZV, CMV, EBV, HHV-6, HBV, HIV |
zanamivir age limit | must be >7 yr |
oseltamivir age limit | must be >1 yr |
amantadine age limit | must be >1yr |
rimantadine age limit | adults only |
MOA of nueraminidase inhibitors | inhibit cleavage of sialic acid, which prevents the release of newly formed viruses |
MOA of palivizumab | monoclonal Ab that binds to Fusion (F) protein, preventing infection of host cell |
virus treated by palivizumab | RSV |
dosing for palivizumab | monthly |
mechanism of administration for ribavirin | inhaled |
pts on ribavirin should avoid contact with | pregnant women or women trying to become pregnant |