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Lecture Unit 1

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Answer
Properties of muscle tissue   EXCITABILITY: Responds to stimuli from neurons. CONTRACTILITY: Is able to shorten. Flex muscles, shorter & fatter. ELASTICITY: Can recoil after contraction. EXTENSIBILITY: Capable of stretching during flexion of antagonistic muscles.  
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Functions of muscle tissue   MOVEMENT-works with skeletal system. MAINTENANCE OF POSTURE. TEMPERATURE REGULATION. STORAGE & MOVEMENT OF MATERIALS. SUPPORT ABDOMINAL ORGANS. JOINT STABILIZATION-muscle tone.  
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Three Types of muscle tissue   Cardiac-only in heart, Smooth-all organs, blood vessels, Skeletal-attached to skeleton.  
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Characteristics of cardiac muscle   In myocardium. Fibers Y shaped/branched. Uninucleated (small percentage are binucleated). Striated-striped dark and light proteins. Involuntary. Intercalcated discs-junction point between heart cells. Auto-rhythmic-contracts 100b/m w/o nervous system.  
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Characteristics of smooth muscle   In walls of visceral organs. Fusiform shape (wide middle and tapered at each end). Uninucleate. No striations. Involuntary. Fatigue resistant.  
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Characteristics of skeletal muscle   Made of cylindrical muscle cells (myofibers). Fiber-like (long and cylindrical) Multinucleate-from fused myoblasts. Striated. Voluntary. Contains myoglobin-O2 binding pigment. Innervated-neuromuscular junctions. Vascular.  
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Myoblasts fuse to form a:   Skeletal muscle fiber. Myoblasts become multi-nucleated.  
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Connective tissue wrappings   Endomysium, Perimysium, Epimysium, Deep Fascia, All four are continuous with the tendon. Help produce movement.  
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Endomysium   Surrounds each muscle fiber. Areolar and reticular fibers.  
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Perimysium   Surrounds groups of muscle fibers (fascicles). Dense irregular CT.  
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Epimysium   Surrounds whole muscle (group of fascicles). Dense irregular CT.  
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Deep fascia   Surrounds muscle groups. Dense irregular CT. Superficial.  
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Muscle attachments   Tendons, Origin, Insertion.  
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Tendons   Attach muscle to bones, skin, cartilage. Aponeruosis is a flat tendon (ex. galea aponeruotica).  
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Origin   Less movable attachment of muscle.  
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Insertion   More movable attachment of muscle.  
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Microscopic Anatomy   Sarcolemma, Sarcoplasm, Transverse tubules or T-tubules, Sarcoplasmic reticulum.  
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Sarcolemma   Cell membrane  
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Sarcoplasm   Cytoplasm  
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Transverse tubules or T-tubules   Invaginations of sarcolemma. Conduct impulses to deepest regions of cell  
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Sarcoplasmic reticulum   Elaborate smooth ER. Surrounds each myofibril. Stores calcium. Contains terminal cisternae-site of calcium release. Right next to T. tubules.  
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Order of muscle organization. Largest to smallest   1. Muscle 2. Facicle 3. Myofiber 4. Myofibrils 5. Myofilaments  
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Myofibrils   Found inside of muscle fibers. Shorten during muscle contraction. Long row of repeating segments-sarcomeres. Composed of myofilaments. Organelle.  
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Myofilaments   Composed of thin and thick filaments. Thin filaments: actin, troponin, and tropomyosin. Thick filaments: Myosin. Be able to label all 4. Troponin/Tropomyosin complex=TTC-referred to together. Molecule.  
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Sarcomeres   Functional unit of the skeletal muscle fiber. Responsible for striated appearance of muscle. Defined from z disc (or line) to z disc.  
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Sliding Filament Theory (Steps 1-3)   1. Nerve impulse causes sarcoplasmic reticulum to release Ca from terminal cisternae. 2. Ca binds to troponin. 3. Troponin-Tropomyosin complex (TTC) slides off of binding sites on actin.  
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Sliding Filament Theory (Steps 4-6)   4. Myosin heads (thick filaments) attach to actin (thin fil). 5. Heads swivel inward, pulling the actin toward center of sarcomere. 6. Myosin heads release; process repeated. (Actin-myosin binding powered by ATP & triggered by Ca2+).  
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Rigor Mortis   Death is not an event but a process. Tissues continue to live after the brain, heart, and lungs fail. A few hrs after death, ATP runs out: Myosin cant detach from actin. Calcium cant be taken up by SR. Leads to continual muscle contration.  
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After Rigor Morits   After 15-24 hours the myofibrils begin to deteriorate allowing muscles to relax. Random twitching can occur. Cells live until they run out of oxygen and glucose. Muscle cells live for 1-2 days. Skin/hair can live for a couple of weeks.  
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Tetanus   Caused by the bacterium Clostridium tetani. Excessive muscle contraction. Stuck contracted, over contracted.  
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Botulism   Caused by the bacterium Clostridium botulinum. Muscular paralysis. Under contration. Botox approved by FDA in 2002. Lessen appearance of wrinkles by paralyzing muscles. Effects last for 120 days.  
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Terminal cisternae   dead-end sacs of the sarcoplasmic reticulum that border T-tubules, calcium is stored here  
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