Block 6- Urea cycle
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Where is urea synthesized? | liver
🗑
|
||||
| What is the structure of urea? | 2 amino groups attached to a central carbonyl group
🗑
|
||||
| Where do the parts of urea come from? | Carbonyl derived from CO2, 1 N-atom from aspartate (asp) the other from ammonium
🗑
|
||||
| Where does Urea synthesis begin and end within the cell? | Mitochondria to start, cytoplasm to finish
🗑
|
||||
| How much energy is required to run the urea cycle? | 4 ATPs
🗑
|
||||
| What is the crucial, rate limiting first enzyme for urea synthesis (found in mitochondria)? | carbamoyl phosphate
🗑
|
||||
| What is the second enzyme of the urea cycle? Also rate limiting | Ornithine transcarbamoylase condenses carbamoyl phosphate with ornithine to form citruline
🗑
|
||||
| The most common genetic defiencies in urea cycle are associated with what? | the two enzymes: carbamoyl phosphate & ornithine transcarbamoylase
🗑
|
||||
| What does arginase do in the urea cycle? Where? | cleaves arginine into urea and ornithine (which is recycled.
🗑
|
||||
| Where does apspartate occur in the urea cycle? | It enters in the cytoplasm to convert citrulline to argininosuccinate which cleaves to form fumarate and arginine by a lyase.
🗑
|
||||
| Is all the arginine required available via urea synthesis? | No, most comes from diet.
🗑
|
||||
| What happens with CPS-1 and Ornithine transcarbamoylase deficiency? | Hyperammonenemia; Decrease in BUN (Blood Urea Nitrogen, Cerebral edema;lethargy, convulsion, coma, death
🗑
|
||||
| What is the difference between Aspartate and Fumarate? | fumarate does not have the amino group
🗑
|
||||
| Where does fumarate go following the urea cycle? | It can enter the TCA for energy or gluconeogenesis
🗑
|
||||
| Where does urea go from the kidney? | Transported by blood to the kidney
🗑
|
||||
| What is the famous phrase regarding the urea cycle? | Better to be pissed off, than pissed on
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
El Diablo
Popular Biochemistry sets