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define atherosclerosis   it is a disease where plaque forms in your arteries  
charactersitics   irregular lipid deposits in intima of large/medium arteries - core made out of cholesterol ester - surrounding area - fibrosis and calcification  
consequences of atherosclerosis   haemmorage into plaque, narrowing lumen of artery - low blood flow - thrombosis  
risk factors   advanced agemalesmokingdiabetes mellitushypertension  
risk factors on biochemical level   apo b100,a1,eLCAT;ACATlipoprotein lipase  
clinical implications   myocardial infarctionsenile dementiagangrenesstroke  
treatment   correct lifestyle, proper diet, drugs which INC HDL and DEC VLDL AND LDL eg. statin - inhibits hmg coa reductase + niacin - decrease vldl formation  
T/F -endothelial damage causes the endothelial cells to adhere to LDL   TRUE  
t/f macrophages then consume lipoproteins then form CYTOKINES   FALSE  
T/F - macrophages consume lipoproteins and then form foam cells   TRUE  
what do foam cells secrete...?   CYTOKINES - for attraction of other macrophagesGROWTH FACTORS - proliferation of smooth muscle cells and fibroblasts  
smooth muscle cells then produce ___________and take up __________ to become foam cells   collagen lipids  


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