atherosclerosis
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| define atherosclerosis | it is a disease where plaque forms in your arteries
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| charactersitics | irregular lipid deposits in intima of large/medium arteries - core made out of cholesterol ester - surrounding area - fibrosis and calcification
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| consequences of atherosclerosis | haemmorage into plaque, narrowing lumen of artery - low blood flow - thrombosis
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| risk factors | advanced agemalesmokingdiabetes mellitushypertension
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| risk factors on biochemical level | apo b100,a1,eLCAT;ACATlipoprotein lipase
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| clinical implications | myocardial infarctionsenile dementiagangrenesstroke
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| treatment | correct lifestyle, proper diet, drugs which INC HDL and DEC VLDL AND LDL eg. statin - inhibits hmg coa reductase + niacin - decrease vldl formation
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| T/F -endothelial damage causes the endothelial cells to adhere to LDL | TRUE
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| T/F- ENDOTHELIAL CELLS + LDL = MACROPHAGES | TRUE
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| t/f macrophages then consume lipoproteins then form CYTOKINES | FALSE
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| T/F - macrophages consume lipoproteins and then form foam cells | TRUE
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| what do foam cells secrete...? | CYTOKINES - for attraction of other macrophagesGROWTH FACTORS - proliferation of smooth muscle cells and fibroblasts
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| smooth muscle cells then produce ___________and take up __________ to become foam cells | collagen lipids
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Created by:
ahmeda101
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