Drugs 2 for Biochem Class
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Inhibits complex III (Cytochrome c reductase) of the ETC | Antimycin A
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Inhibits ATP translocase | Aphidicolin
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Prevents ATP production by phosphoglycerate kinase | Arsenate
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Irreversible inhibitor of COX-1 | Aspirin
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Inhibits CPSII, CTP synthetase and PRPP amidotransferase | Azaserine
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Inhibits carbamoyl phosphate synthetase II | Azaserine
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Chain terminators to inhibit viral DNA repliation | AZT and didanosine
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Inhibits Complex IV (Cytochrome oxidase) of the ETC | Cyanide, CO, Azide (N3)
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Inhibits Na+/K+-ATPase | Digoxin
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Covalently modifies eEF2, inactivates it and inhibits translation | Diptheria toxin
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Inhibits Type II topoisomerase in humans | Etoposide
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Inhibits enolase | Flourine
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Suicide inhibitor of thymidylate synthase | Fluorouracil
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Inhibits thymidylate synthase | Fluorouracil
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An anticancer drug that is a suicide inhibitor of thymidylate synthetase | Fluorouracil
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This anticancer drug inactivates thymidylate synthetase and therefore inhibits DNA synthesis. | Fluorouracil
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Effective in the treatment of DVT because it acts to inhibit the activity of thrombin | Heparin
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Used in the treatment of tuberculosis, this reacts with pyridoxal leading to a B6 deficiency | Isoniazid
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Inhibits de novo synthesis of purines, thereby inhibitin DNA synthesis. | Mercaptopurine
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Inhibits aspartate transcarbamoylase (the pyrimidine biosynthetic enzyme) and prevents DNA replication | N-phosphonacetyl-L-aspartate) PALA
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Irreversible inhibitor of transpeptidase involved in cell wall synthesis | Penicillin
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These three enzymes inhibit DNA gyrase and prevent the growth of E. coli | Quinolones, nalidixic acid and ciprofloxacin
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Hydrolyzes 28S RNA and inactivates ribosomes | Ricin
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Ligand for estrogen receptor | Tamoxifen
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Vitamin K analog that inhibits the regeneration of Vitamin K | Warfarin (Coumadin)
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Antibacterial agents which competitively inhibit digydropteroate synthase | Sulfonamides
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Inhibits dihydrofolate recuctase (DHFR) | Trimethoprim
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Inhibits ATP Synthase | Oligomyacin
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