Enzymes
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| Synthesizes the active tetrahydrofolate (THF) form of folic acid. | Dihydrofolate reductase | ||||
| Makes a phosphodiester bond between adjacent nucleotides in DNA | DNA ligase | ||||
| Adds TTAGGG sequences to the ends of chromosomes | Telomerase | ||||
| Synthesizes deoxy form of nucleotides | Ribonucleotide reductase | ||||
| Salvages guanine bases to make GMP | HPRT | ||||
| Catalyzes formation of uric acid | Xanthine oxidase | ||||
| Has a MG++ cofactor that funcitons to enhance nucleophilic attack by the 3'O of the primer strand | DNA polymerase | ||||
| Synthesizes an RNA primer to initiate strand synthesis | Primase | ||||
| Separates the parental strands at the replication fork | Helicase | ||||
| The biochemical function of cAMP is to activate _______________. | Protein kinase A | ||||
| An enzyme that digests DNA at specific base sequences. | |||||
| Inhibited by malathion | Acetylcholinesterase | ||||
| Catalyzes the first step in glycolysiss that produces ATP by substrate-level phosphorylation | Phosphoglycerate kinase | ||||
| Has a high Km for glucose and is acive after a meal | Glucokinase | ||||
| Covalently links amino acids to their cognate tRNAs | Aminoacyl-tRNA synthetase | ||||
| Synthesizes cDNA from mRNA | resverse transcriptase | ||||
| Synthesizes RNA | RNA polymerase | ||||
| The enzyme primarily responsible for metabolizing alcohol | Alcohol dehydrogenase | ||||
| Stimulates the activity of phosphofructokinase-1 (PFK-1) | Fructose 2,6-bisphosphate | ||||
| Catalyzes the production of NADH in glycolysis | Glyceraldehyde 3-P dehydrogenase (GAPDH) | ||||
| Major regulated step of cholesterol biosynthesis | HMGCoA reductase | ||||
| Enzyme in eukaryotes that is responsible for mRNA transcription | |||||
| Pyruvate carboxylase enzyme requires ___________. | Biotin | ||||
| Catalyzes the first enzymatic step of steroid synthesis | Desmolase | ||||
| Pyruvate dehydrogenase requires this as a cofactor. | thiamin-pyrophosphate | ||||
| Homocysteine methyltransferase requires this as a cofactor | Cobalamin (B12) | ||||
| Recognizes oriC and recruits the replication proteins | E. coli DnaA | ||||
| Seals the nick in the phosphodiester backbone | DNA ligase | ||||
| Introduces negative supercoils in the DNA | DNA gyrase | ||||
| Synthesizes the bulk of human DNA | DNA polymerase delta | ||||
| Functions as a "sliding clamp" to make polymerase processive | PCNA | ||||
| Inhibited by methotrexate | Dihydrofolate reductase | ||||
| Inhibited by ciprofloxacin | DNA gyrase | ||||
| Inhibited by azaserine | Carbamoyl phosphate synthetase II | ||||
| Inhibited by allopurinol | Xanthine oxidase | ||||
| Inhibited by fluorouracil | Thymidylate synthase | ||||
| First step in the metabolism of alcohol | Alcohol dehydrogenase | ||||
| Cleaves the signal peptide from the N-terminus of the growing polypeptide | Signal peptidase | ||||
| Breaks and reforms S-S bonds between cystein residues in protein folding | Protein disulfide isomerase (PDI) | ||||
| Shifts proline configuratin between cis and trans isomers | Peptidyl proline isomerase (PPI) | ||||
| Allows proteins containing proline to adopt the correct configuration | Peptidyl proline isomerase (PPI) | ||||
| Phosphorylates translational initiation factors (Ifs)leading to the inhibition of translation and reduces proteins entering the ER | Protein ER Kinase (PERK) | ||||
| A complex of E2/E3 which recognizes and tags a damaged protein for destruction. | Ubiquitin ligase | ||||
| Enzyme that cleaves fatty acids from phsopholipids. | Phospholipases | ||||
| Hydrolyzes the ester on the C1 carbon of a phospholipid, giving a free fatty acid and a 1-lysophospholipid | Phospholipase A1 | ||||
| Hydrolyzes the ester on the C2 carbon of a phospholipid, giving a free fatty acid and a 2-lysophospholipid | Phospholipase A2 | ||||
| Hydrolyzes the phosphoester bond between the phosphate and the glycerol backbone giving DAG and phosphorylated head group in a phospholipid | Phospholipase C | ||||
| Hydrolyzes the phosphoester bond between the phosphate and the head group giving PA and free head group in a phospholipid | Phospholipase D | ||||
| Synthesizes cAMP | Adenylyl cyclase | ||||
| Breaks down cAMP | Phosphodiesterase |
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Created by:
P1StudyStack
on 2008-12-14